Preparation and Evaluation of Extended Release Matrix Tablet of Salbutamol Sulphate
DOI:
https://doi.org/10.22270/ajprd.v12i2.1380Abstract
The purpose of this research was to see how the physicochemical properties and porosity of matrix tablets containing various types of natural polymers affected the release of salbutamol sulphate. The sustained drug delivery systems are designed to achieve a constant release of drug from the formulation. The therapeutic levels are adequately maintained throughout the dosing interval. Moreover, the constant rate of absorption also reduces the dosing frequency and thus improves patient compliance. Natural polymer obtained from the gummy exudates and plant fibers. Various natural polymers in use are xanthan gum, acacia, guar gum, agar, carrageenan, chitosan gelatin, etc. With the advancements in technology and insutrial products, natural polymer manufacturing industry has come a long way. India has been serving the polymer producing industry since a long time. Salbutamol sulphate released in a controlled manner to a patient needing this therapy, thereby resulting in a better patient compliance. Accordingly, this study was designed to enhance the bioavailability of drug by prolonging its duration in the stomach as matrix type dosage forms with controlled release. Extended release matrix tablets of salbutamol sulphate were prepared by the direct compression method, using locust bean gum and HPMC K 15M as polymers. The effect of the nature of polymers was studied by preparing various formulations of extended release matrix mucoadhesion tablets.
Downloads
References
Robinson JR, Lee VHL. Controlled drug delivery: fundamentals and applications, Marcel Dekker, New York, 1987, 1 (3), 95-138.
Katdare V, Keller KO, Christoff JJ, et al. Evaluation of dissolution characteristics of an encapsulated water soluble tablet granulation. Drug Dev Indus Pharmacy, 1990, 16, 1109-1119.
Banker GS, Rhodes CT. Modern pharmaceutics, Marcel Dekker, New York, 2002, 4, 678-721.
Vyas SP, Khar RK. Controlled drug delivery concepts and advances, Vallabh Prakashan, Delhi, India, 2002, 1, 155-217.
Chein YW. Novel drug delivery systems, Revised and Expanded Marcel Dekker, New York, 1992, 2(2), 140-155.
Lachman L, Liberman HA, Kanig JL. The theory and practice of industrial pharmacy, Verghese publishing house, 1987, 3, 453-454.
Mishra B, Bansal A, Sankar C. Development and in vitro evaluation of hydrophilic matrix tablets of diltiazem Hcl. Acta pharm jurcica, 2005, 47, 115-126.
Lourdes O, Manuela I, Rosa M et al. Preparation of sustained release hydrophilic matrices by melt granulation in a high- shear mixer. Journal Pharm Science, 2005, 164, 132-140.
Ravi MNK. Nano and microparticles as controlled drug delivery devices. Journal Pharma Science, 2000, 56, 234-58.
Kamboj S, Gupta GD, Oberoy J. Matrix tablets: An important tool for oral controlled release dosage forms. Pharmainfo.net, 2009, 7.
Dey NS, Majumdar S, Rao MEO. Multiparticulate drug delivery systems for controlled release. Trop Journal Pharma Research, 2008, 7, 1067-1075.
Kumaran KS, Manjunath SY, Wamorkar VV. Development of a floating multiple unit controlled release system for mosapride. Asian Journal Pharma, 2010, 4, 163-167.
Published
Versions
- 2024-04-23 (2)
- 2024-04-15 (1)
How to Cite
Issue
Section
Copyright (c) 2024 Ajeet Yadav, Naveen Gupta, Dharmendra Singh Rajput
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).