Preparation and Evaluation of Buccal Mucoadhesive Tablets of Antihypertensive Drug

Authors

  • Aman Shrivastava Madhyanchal professional University, Bhopal, M.P.
  • Dharmendra Singh Rajput Madhyanchal professional University, Bhopal, M.P.
  • Devendra Kushwaha Madhyanchal professional University, Bhopal, M.P.

DOI:

https://doi.org/10.22270/ajprd.v13i1.1493

Abstract

Buccal route of drug delivery has significant attention to the systemic circulation through the jugular vein bypassing the first pass hepatic metabolism leading to high bioavailability. Such routes have expanded important notice due to their presystemic metabolism or instability in the acidic environment associated with the oral administration. Along with the variety of buccal layer mucosae of the oral cavity has convenient and easily effective site for the delivery of therapeutic agents. Lercanidipine a suitable candidate for buccal delivery. Hence, in this research work an attempt was made to formulate buccal tablets of Lercanidipine hydrochloride to increase patient compliance by reducing dosing frequency and to achieve plasma concentration profile over 12 h.

 

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Author Biographies

Aman Shrivastava, Madhyanchal professional University, Bhopal, M.P.

Madhyanchal professional University, Bhopal, M.P.

Dharmendra Singh Rajput , Madhyanchal professional University, Bhopal, M.P.

Madhyanchal professional University, Bhopal, M.P.

Devendra Kushwaha, Madhyanchal professional University, Bhopal, M.P.

Madhyanchal professional University, Bhopal, M.P.

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Published

2025-02-15

How to Cite

Shrivastava, A., Rajput , D. S., & Kushwaha, D. (2025). Preparation and Evaluation of Buccal Mucoadhesive Tablets of Antihypertensive Drug. Asian Journal of Pharmaceutical Research and Development, 13(1), 35–41. https://doi.org/10.22270/ajprd.v13i1.1493

Issue

Vol. 13 No. 1 (2025): Volume 13 Issue 1 JAN- FEB. 2025

Section

Research Articles

Copyright (c) 2025 Aman Shrivastava, Dharmendra Singh Rajput , Devendra Kushwaha

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