Fabrication of Nanogel for Topical Drug Delivery of Montelukast

  • Trapti Pandey Department of Pharmacy, VNS Faculty of Pharmacy, Bhopal
  • Neeraj Sharma Department of Pharmacy, VNS Faculty of Pharmacy, Bhopal
  • Naveen Gupta Department of Pharmacy, VNS Faculty of Pharmacy, Bhopal
  • Dharmendra Gupta Department of Pharmacy, VNS Faculty of Pharmacy, Bhopal
  • Kuldeep Tripathi Department of Pharmacy, VNS Faculty of Pharmacy, Bhopal

Abstract

A novel nanocrystal system of montelukast (MTK) was designed to improve the transdermal delivery, while ensuring chemical stability of the labile compound. MTK nanocrystal Nanogel was fabricated using using nano dispersion method (Modified emulsification diffusion method). In the pre-formulation study, there was not any physicochemical interaction between drug and polymer had been evaluated by FTIR. The melting point was found to be 134- 137 0C. It is freely soluble in Cyclohexane & butanol ratio and water. The standard curve of ondansetron had been prepared by Cycloheaxxane & butanol (7:3). Montelukast nanogel were prepared by nanodispersion method. Formulations of different drug ratio were optimized with selected parameters like particle size, PDI, Zeta potential, entrapment efficiency, clarity test. pH test of gel, viscosity and gelation temperature. Drug release studies were performed by dialysis bag diffusion technique at a temperature (37°C). The study was continued for 24 hours till. The maximum amount of drug montelukast release 87% within 24 hr. The study was monitored at 37°C. Preparation, characterization and drug release study of montelukast loaded nanogel. This approach of montelukast loaded nanogel with chitosan as the polymer is quite successfully developed.


 


 

Keywords: Montelukast; Nanogel; Transdermal delivery; Topical Drug Delivery

Downloads

Download data is not yet available.

Author Biographies

Trapti Pandey, Department of Pharmacy, VNS Faculty of Pharmacy, Bhopal

Department of Pharmacy, VNS Faculty of Pharmacy, Bhopal

Neeraj Sharma, Department of Pharmacy, VNS Faculty of Pharmacy, Bhopal

Department of Pharmacy, VNS Faculty of Pharmacy, Bhopal

Naveen Gupta, Department of Pharmacy, VNS Faculty of Pharmacy, Bhopal

Department of Pharmacy, VNS Faculty of Pharmacy, Bhopal

Dharmendra Gupta, Department of Pharmacy, VNS Faculty of Pharmacy, Bhopal

Department of Pharmacy, VNS Faculty of Pharmacy, Bhopal

Kuldeep Tripathi, Department of Pharmacy, VNS Faculty of Pharmacy, Bhopal

Department of Pharmacy, VNS Faculty of Pharmacy, Bhopal

References

1. Alexander V. Kabanov and Serguei V. Vinogradov. 2008. Nanogels as Pharmaceutical Carriers, Multifunctional Pharmaceutical Nanocarriers, Springer Science, New York, 67-80.
2. Dhawal dorwal, Nanogels as novel and versatile pharmaceuticals , Int J Pharm Pharm Sci, 2012; 4 (3): 67-74.
3. Sharma, S.; Gupta, D.; Sudan, P.; Jain, U. K. Pharm. Chem. J. 2016, 3, 125.
4. Sultana, F.; Imran-Ul-Haque, M.; Arafat, M.; Sharmin, S. J. Appl. Pharm. Sci. 2013, 3, 95.
5. Zhang, H.; Zhai, Y.; Wang, J.; Zhai, G. Mater. Sci. Eng. C. 2016, 60, 560.
6. Soni, K. S.; Desale, S. S.; Bronich, K. J. Control Rel. 2016, 240, 109.
7. Sharma, A.; Garg, T.; Aman, A.; Panchal, K.; Sharma, R.; Kumar, S.; Markandeywar, T. Artif. Cells Nanomed. Biotechnol. 2014, 44, 165.
8. Adhikari, B.; Sowmya, C.; Reddy, C. R.; Haranath, C.; Bhatta, H. P.; Inturi, R. N. World J. Pharm. Pharm. Sci. 2016, 5, 505.
9. Rathod, H. J.; Mehta, D. P. Int. J. Pharm. Sci. 2015, 33, 121.
10. Bajpai, V. Int. J. Pharm. Sci. 2014, 3, 577.
11. Sharma, S.; Gupta, D.; Sudan, P.; Jain, U. K. Pharm. Chem. J. 2016, 3, 125.
12. Ismail, H.; Irani, M.; Ahmad, Z. Int. J. Polym. Mater. Polym. Biomater. 2013, 62, 411.
13. Ahmed, E. M. J. Adv. Res 2015, 6, 105.
14. Al Kinani, A. A.; Zidan, G.; Elsaid, N.; Seyfoddin, A.; Alani, A. W. G.; Alany, R. G. Adv. Drug Deliv. Rev. 2017. DOI: 10.1016/j.addr.2017. 12.017 (Article in press).
15. Cheng, W.; Chen, Y.; Teng, L.; Lu, B.; Ren, L.; Wang, Y. J. Colloid Interface Sci. 2018, 513, 314.
16. Alsaab, H.; Bonam, S. P.; Bahl, D.; Chowdhury, P.; Alexander, K.; Boddu, S. H. J Pharm. Pharm. Sci. 2016, 19, 252.
17. Soni, K. S.; Desale, S. S.; Bronich, K. J. Control Rel. 2016, 240, 109.
18. Adhikari, B.; Sowmya, C.; Reddy, C. R.; Haranath, C.; Bhatta, H. P.; Inturi, R. N. World J. Pharm. Pharm. Sci. 2016, 5, 505.
Statistics
53 Views | 3 Downloads
How to Cite
Pandey, T., Sharma, N., Gupta, N., Gupta, D., & Tripathi, K. (2022). Fabrication of Nanogel for Topical Drug Delivery of Montelukast. Asian Journal of Pharmaceutical Research and Development, 10(6), 53-60. https://doi.org/https://doi.org/10.22270/ajprd.v10i6.1190