Design, Development and Evaluation of Enteric Coated Tablets of Famotidine
DOI:
https://doi.org/10.22270/ajprd.v10i6.1094Keywords:
Famotidine, Preformulation, In vitro, Stability StudiesAbstract
The aim of the present study was to formulate and evaluate of enteric coated Famotidine sodium sesquihydrate tablets by using manotol, dicalcium phosphate, microcrystalline cellulose, crossrmelose sodium, magnesium starate and talc. FT-IR study was carried out to check any possible interactions between the drug and the excipients manotol, dicalcium phosphate, microcrystalline cellulose, crosscarmelose sodium, Famotidine sodium sesquihydrate were prepared by direct compression method using different concentration of, Avicel PH (MCC) as filler, mannitol and dicalcium phosphate as diluents, croscarmellose sodium as disintegrating agents, magnesium stearate and talc was used as a glidant and lubricant respectively. The granules were evaluated for the precompression parameters like angle of repose, bulk density, tapped density and compressibility index. The flow characteristics of the granules were assessed by determining their angle of repose and Carr’s Index. The values of compressibility index and angle of repose signify good flowability of the granules for all the batches. This shows that the granules had smooth flow properties ensuring homogenous filling of the die cavity during the compression (punching) of tablets.
Downloads
References
2. Dhaval JP, Jayvadan KP, Vikram MP. Improvement in the dissolution of poorly water soluble drug using media milling technique. Thai J Pharm Sci. 2010;34:155-64
3. Heinz L, Albrecht Z, Klaus M. Color Atlas of Pharmacology. 2nd Ed. Thieme Stuttgart New York • 2000;166
4. Health encyclopedia diseases and conditions. http://www.healthscout.com.
5. http://familydoctor.org/online/famdo.con/home/common/digestive/disorders/186.html.( Accessed on 10/02/2011)
6. http://www.emedmag.com/html/pre/gic/consults/071503.asp.(Accessedon12/02/2011)
7. http://en.wikipedia.org/wiki/Peptic_ulcer. (Accessed on 10/02/2011) http://www.experiencefestival.com/a/Peptic_ulcerPathophysiology.(Accessed on 03/10/2012)
8. Tripathi KD. Essential of Medical Pharmacology. 5th Ed. Jaypee Brothers Medical Publishers (P) Ltd. New Delhi: 2003; 631
9. Nicole GM. Clinical effects of proton pump inhibitors. Erasmus University.2010;1-2.
10. Richard F, Michelle A, Luigi X. Lippincott's Illustrated Reviews: Pharmacology, 4th Ed. Lippincott Williams & Wilkins. 2009; 331.
11. Bertram GK, Susan B. Masters, Anthony J. Trevor. Basic & Clinical Pharmacology, 11th Ed. by The McGraw-Hill Companies, 2009; 1479.
12. Jayesh P, Manish R. Tablet Formulation Design And Manufacture: Oral Immediate Release Application. Pharma Times April 2009; 41( 4): 22.
13. Karl T, Karoline B, Enteric coated hard gelatin capsules. Department of Pharmaceutical Technology, Ludwig Maximilian University, 8000 Munich 2, Germany. Capsugel Library. 1-3.
14. Liberman, Lachman L. The Theory and Practice of Industrial Pharmacy.3rd Ed, Verghese Publication House.1987; 293.
15. Neelam DK, Prafulla SC, Rajesh J. Innovations In Tablet Coating Technology: A Review. IJABPT. Jan-Mar -2011; 2(1): 214-217.
16. Salam W. Dumitru L. Directly Compressible Adjuvants- A Pharmaceutical Approach. Farmacia. 2008; Vol LVI 6:591-593.
17. Rabia B, Muhammad H, Nousheen A. Formulation Development And Optimization Of Ibuprofen Tablets By Direct Compression Method. Pak. J. Pharm. Sci. April 2008; 21(2) : 113.
18. Rakesh P, Mansi B, Directly Compressible Materials via Co-Processing International Journal of PharmTech Research. 2009; 1(3): 745-748.
19. Olowosulu AK, Avosuahi O, Isah AB. Formulation and Evaluation of Novel Coprocessed Excipients of Maize Starch and Acacia Gum (StarAc) For Direct Compression Tabletting. International Journal of Pharmaceutical Research and Innovation. 2011; 2: 39-40.
20. Herbert A. Lieberman, Leon Lachman, Joseph B. Schwartz. Pharmaceutical Dosage Forms: Tablets. 2nd Ed.. Marcel Dekker. 1989; 214.
21. British Pharmacopoeia. London: The stationary office. 2003; (1).
22. Indian Pharmacopoeia. Delhi: The controller of publications. 1996; (1).
23. Famotidine sodium sesquihydrate available at: http:// www Rx list.com.
24. Raymond C, Paul J, Marian E. Handbook of pharmaceutical excipients. 6th Ed..
25. London: The Pharmceutical Press. 2009; 94, 129, 206, 404, 424, 928.
26. Sumit C, Sibaji S, Sujit D. Formulation Development and Evaluation of Famotidine Enteric Coated Tablets. Int. J. Chem Tech Res. 2009; 1(3): 663-666.
27. Anroop N, Rachna G, Rachna K, Shery J, Mahesh A. Formulation and Evaluation of Enteric Coated Tablets of Proton Pump Inhibitor, Journal of Basic and Clinical Pharmacy. 2010; 1(4).
28. Saffar M, Rajeev S, Sophia D. Comparative in vitro evaluation of commercially available Famotidine tablets. Kathmandu University Journal Of Science, Engineering And Technology. 2007; 1(3): 1-7
29. Chanchal M, Anil G, Mukesh S, Asha R. Famotidine and its enteric coating polymer concentration for stable coating in acid media in stomach. International Journal of Pharmaceutical and Clinical Research. 2011; 3(2): 45-47.
30. Putta K, Hiremath D, S. Rajendra. Enteric coated tablets of novel proton pump inhibitor with super disintegrants design, in-vitro evaluation and stability studies. Journal of Applied Pharmaceutical Science. 2011; 01 (06): 106-111.
31. Bozdag S, Çalis S, Sumnu M. Formulation and stability evaluation of enteric-coated omeprazole formulations. S.T.P. Pharma Sciences. 1999; 9 (4): 321-327.
32. Mohamed N, and Hazem H. Pharmacokinetics and bioequivalence evaluation of two omeprazole enteric-coated formulations in healthy egyptian male volunteers. Journal of Applied Sciences Research. 2009; 5(9): 1190-1194.
33. Devraj, Bhatt DC. Studies on enteric coated sustained timed-release tablets of metronidazole. J. Chem. Pharm. Res. 2010; 2(2): 226-232.
34. Dhruba G, Prasanta C, Sandeep G, Romy Sh. Formulation design and optimization of an enteric coated sustained release mucoadhesive tablet of metronidazole. Int. J. PharmTech Res. 2010; 2(2): 1269-1275.
35. Durriya H, Fahim M, Harris S, Zafar M, Rabia B, Rabial Y. Development of enteric coated flurbiprofen tablets using opadry/acryl-eze system—a technical note. AAPS PharmSciTech. 2008; 9(1): 116-121.
Published
How to Cite
Issue
Section
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.