Design, Development and Evaluation of Gastro- Retentive Mucoadhesive Microballons of Lansoprazole for Management of Peptic Ulcer

  • Jitendra Kumar School of Pharmacy, Madhyanchal Professional University, Bhopal, M.P
  • Dharmendra Singh Rajput School of Pharmacy, Madhyanchal Professional University, Bhopal, M.P
  • Naveen Gupta School of Pharmacy, Madhyanchal Professional University, Bhopal, M.P
  • Neeraj K Sharma School of Pharmacy, Madhyanchal Professional University, Bhopal, M.P

Abstract

A major problem for gastric delivery is the attainment of an optimal concentration at site of action with maximum bioavailability of drugs. The problem is associated with the conventional dosage form for peptic ulcer diseases is frequent dosing due to the low half life. The bioavailability of an instilled compound is generally low from 1.5 – 3.0 h and low solubility, with only a small fraction reaching the target site. In the present study an attempt was made to develop a mucoadhesive Microballons of  Lansoprazole with variation in polysaccharide polymeric combination with different ratios to increase mucoadhesion at gastric mucosa, which increase the gastric residence time, thus increase the bioavailability.The result indicated that the drug have maximum solubility water, and also  soluble in 0.1 N HCl. The partition coefficient of  Lansoprazole HCl was found to be (0.2442). The FTIR spectrum is shown in Figure. The characteristic peaks of  Lansoprazole HCl were observed at 3290, 3220, 3127, 3084, 2975, 2820, 2819, 2781, 1621, 1517, 1420, 1418, 1425, 1412, 1317 and 1319 cm-1.The prepared mucoadhesive microballons were determine for percentage yield and the range of percentage yield is 89.2 % - 95.9. The Shape and surface morphology of prepared mucoadhesive microballons was shown by photograph by scanning electron microscope in Figure.


 

Keywords: Lasnoprazole, Preformulation, In vitro, Peptic ulcer, Microballona

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Author Biographies

Jitendra Kumar, School of Pharmacy, Madhyanchal Professional University, Bhopal, M.P

School of Pharmacy, Madhyanchal Professional University, Bhopal, M.P

Dharmendra Singh Rajput, School of Pharmacy, Madhyanchal Professional University, Bhopal, M.P

School of Pharmacy, Madhyanchal Professional University, Bhopal, M.P

Naveen Gupta, School of Pharmacy, Madhyanchal Professional University, Bhopal, M.P

School of Pharmacy, Madhyanchal Professional University, Bhopal, M.P

Neeraj K Sharma, School of Pharmacy, Madhyanchal Professional University, Bhopal, M.P

School of Pharmacy, Madhyanchal Professional University, Bhopal, M.P

School of Pharmacy, Madhyanchal Professional University, Bhopal, M.P

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Kumar, J., Rajput, D., Gupta, N., & Sharma, N. (2023). Design, Development and Evaluation of Gastro- Retentive Mucoadhesive Microballons of Lansoprazole for Management of Peptic Ulcer. Asian Journal of Pharmaceutical Research and Development, 10(6), 161-165. https://doi.org/https://doi.org/10.22270/ajprd.v10i6.1092