Microencapsulation to Maintain the Activity and Stability of Drug Substances: A Review

Activity, Stability, Coacervation, Microencapsulation, Spray Drying, Solvent Evaporation

  • Sintia Ayu Almadanti School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147
  • Indra Makmur School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147
  • Ridho Asra School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147
  • Salman Umar Faculty of Pharmacy, Andalas University, Limau Manih Campus, Padang 25163, Indonesia

Abstract

Purpose: The microencapsulation method is one of the most widely used techniques to protect bioactive compounds from various environmental factors such as evaporation, oxidation, degradation of temperature, humidity, and light.  Therefore, it can extend product shelf life and avoid damage so that it can last a long time and can still be utilized by the body well1.


Selection of Data Sources: In compiling a review, this article used a literature study by finding sources or literature in the form of national and international journals in the last 10 years (2010-2020). Data search was also carried out using online media with the keywords as follows: microencapsulation, microcapsules, and microencapsulation methods. The search for the main references used in this review article was conducted through trusted websites such as Science Direct, Pubmed, Google Scholar, and other published and trustworthy journals.


Conclusion: Based on the results of several studies, it can be concluded that microencapsulation using several of the above methods can provide protection for the substance / drug against environmental influences, and it can maintain the stability of a substance / drug so that it can extend the drug release time.


 

Keywords: Activity, Stability, Coacervation, Microencapsulation, Spray Drying, Solvent Evaporation

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Author Biographies

Sintia Ayu Almadanti, School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147

School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147

Indra Makmur, School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147

School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147

Ridho Asra, School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147

School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147

Salman Umar, Faculty of Pharmacy, Andalas University, Limau Manih Campus, Padang 25163, Indonesia

Faculty of Pharmacy, Andalas University, Limau Manih Campus, Padang 25163, Indonesia

References

Wathoni N, Yuan Shan C, Yi Shan W, et al. Characterization and antioxidant activity of pectin from Indonesian mangosteen (Garcinia mangostana L.) rind. Heliyon. 2019;5(8):e02299. doi:10.1016/j.heliyon.2019.e02299

2. Baena-Aristizábal CM, Foxwell M, Wright D, Villamizar-Rivero L. Microencapsulation of Rhizobium leguminosarum bv. trifolii with guar gum: Preliminary approach using spray drying. J Biotechnol. 2019;302:32-41. doi:10.1016/j.jbiotec.2019.06.007
3. Estevinho BN, Rocha F, Santos L, Alves A. Microencapsulation with chitosan by spray drying for industry applications - A review. Trends Food Sci Technol. 2013;31(2):138-155. doi:10.1016/j.tifs.2013.04.001
4. Corrêa-Filho LC, Moldão-Martins M, Alves VD. Advances in the application of microcapsules as carriers of functional compounds for food products. Appl Sci. 2019;9(571):1-18. doi:10.3390/app9030571
5. Hidayah N. Perbandingan Berbagai Teknik Mikroenkapsulasi Pakan dalam Menghasilkan Daging Sapi Sehat. SenasPro. 2016;(0736):143-151.
6. Huo X, Li W, Wang Y, et al. Chitosan composite microencapsulated comb-like polymeric phase change material via coacervation microencapsulation. Carbohydr Polym. 2018;200:602-610. doi:10.1016/j.carbpol.2018.08.003
7. Ang LF, Darwis Y, Por LY, Yam MF. Microencapsulation curcuminoids for effective delivery in pharmaceutical application. Pharmaceutics. 2019;11(9):1-23. doi:10.3390/pharmaceutics11090451
8. Agnihotri N, Mishra R, Goda C, Arora M. Microencapsulation-A Novel Approach in Drug Delivery: A Review. Indo Glob J Pharm Sci. 2020;2(1):1-20. doi:10.5958/2231-5659.2020.00009.0
9. Lengyel M, Kállai-Szabó N, Antal V, Laki AJ, Antal I. Microparticles, microspheres, and microcapsules for advanced drug delivery. Sci Pharm. 2019;87(3). doi:10.3390/scipharm87030020
10. Hassan A, Laghari MS, Rashid Y. Micro-encapsulated phase change materials: A review of encapsulation, safety and thermal characteristics. Sustain. 2016;8(10):1-32. doi:10.3390/su8101046
11. Srifiana Y, Surini S, Yanuar A. Mikroenkapsulasi ketoprofen dengan metode koaservasi dan semprot kering menggunakan pragelatinisasi pati singkong ftalat sebagai eksipien penyalut. J Ilmu Kefarmasian Indones. 2014;12(2):162-169.
12. Ahmadi A, Halim A, Sageeatra A. Mikroenkapsulasi Isoniazid Menggunakan Natrium Carboxymethilcellulose (NaCMC) sebagai Polimer Dengan Metode Pengeringan Semprot. J Farm Higea. 2018;10(1):1-9.
13. Halim A, Daniati R, Wahyuni R. Mikroenkapsulasi Metronidazol Dengan Polimer Hpmc Menggunakan Metoda Penguapan Pelarut. J Farm Higea. 2013;5(1):71-81.
14. Neswita E, Ben ES, Nofita R. Mikroenkapsulasi Atenolol Dengan Penyalut Albumin Menggunakan Metode Penguapan Pelarut. J Katalisator. 2018;3(1):19-30. doi:10.22216/jk.v3i1.3234
15. Rosaini H, Halim A, Astuti R. Mikroenkapsulasi pirazinamida menggunakan manitol dengan metode emulsifikasi penguapan pelarut. J Farm Higea. 2018; 10(1):57-67.
16. Halim A, Arianti O, Umar S. Mikroenkapsulasi Parasetamol dengan Metode Penguapan Pelarut menggunakan Polimer Natrium Karboksimetil ( NaCMC ). J Farm Higea. 2011; 3(2):84-93.
17. Srifiana Y, Surini S, Yanuar A. Mikroenkapsulasi ketoprofen dengan metode koaservasi dan semprot kering menggunakan pragelatinisasi pati singkong ftalat sebagai eksipien penyalut. J Ilmu Kefarmasian Indones. 2014;12(2):162-169.
18. Santos MG, Bozza FT, Thomazini M, Favaro-Trindade CS. Microencapsulation of xylitol by double emulsion followed by complex coacervation. Food Chem. 2015;171:32-39. doi:10.1016/j.foodchem.2014.08.093
19. Klein T, Longhini R, Bruschi ML, De Mello JCP. Microparticles containing Guaraná extract obtained by spray-drying technique: Development and characterization. Rev Bras Farmacogn. 2015;25(3):292-300. doi:10.1016/j.bjp.2015.03.010
20. Sharma M, Sharma V, Panda AK, Majumdar DK. Enteric microsphere formulations of papain for oral delivery. Yakugaku Zasshi. 2011;131(5):697-709. doi:10.1248/yakushi.131.697
21. Lubis SS, Sulastri E, Zubair MS. Mikroenkapsulasi Antosianin Kulit Buah Kakao (Theobroma cacao L.) Dengan Metode Koaservasi Kompleks. J Farm Galen (Galenika J Pharmacy). 2018;4(2):106-112. doi:10.22487/j24428744.2018.v4.i2.11077
22. Deshmukh R, Wagh P, Naik J. Solvent evaporation and spray drying technique for micro- and nanospheres/particles preparation: A review. Dry Technol. 2016;34(15):1758-1772
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How to Cite
Almadanti, S., Makmur, I., Asra, R., & Umar, S. (2020). Microencapsulation to Maintain the Activity and Stability of Drug Substances: A Review. Asian Journal of Pharmaceutical Research and Development, 8(6), 73-76. https://doi.org/https://doi.org/10.22270/ajprd.v8i6.829

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