Antibacterial Activity Test of Mangosteen Plants (Garcinia Mangostana L.): A Review

Authors

  • Rika Andani School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147
  • Anzharni Fajrina School of Pharmaceutical Science (STIFARM) Padan, Indonesia 25147
  • Ridho Asra School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147
  • Aried Eriadi School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147

DOI:

https://doi.org/10.22270/ajprd.v9i1.927

Keywords:

Mangosteen, Garcinia mangostana L., Antibacterial activity, Inhibitor zone.

Abstract

Background: Bacterial infection was a health problem thathard to overcome, due to the presence of bacterial resistance to current antibacterial drugs. Therefore, the use of herbal antibacterials is an alternative that can be used. Mangosteen (Garciniamangostana L.) is a plant that contains xanthone compounds and its derivatives have antimicrobial, antioxidant, cytotoxic, anti-inflammatory, and anti-HIV activity.Part of the mangosteen was used as a medicinal plant such as bark, fruit peel, fruit, seeds, and leaves.This review aimed to determine the antibacterial effectiveness of the mangosteen and inhibitory diameter that was resulting.

Data Collection: The author was created this article review by conducting literature studies. The works of literature were collected from national and international journals in the last ten years (2010-2020) and pharmaceutical scientific books. The works of literature were collected from trusted online journal sites such as the digital library, PubMed, PubChem, ScienceDirect, NCBI, Elsevier, NCBI, Researchgate, Google Scholar, Springer, and other trusted E-resource with the keyword "mangosteen”, “Garcinia mangostana L”, “antibacterial activity”, and “inhibitor zone”. 

Result: According to literature showed that the mangosteen fruit peel, bark, leaves, seeds and fruit effective as antibacterialfor several types of bacteria.

Conclusion:N-hexane that was extracted from mangosteen peel has potential as an antibacterial activity at a concentration of 15.62 mg/ml and inhibit the growth of Staphylococcus aureus ATCC25923 with an inhibitory diameter of 17mm.

 

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Author Biographies

Rika Andani, School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147

School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147

Anzharni Fajrina, School of Pharmaceutical Science (STIFARM) Padan, Indonesia 25147

School of Pharmaceutical Science (STIFARM) Padan, Indonesia 25147

Ridho Asra, School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147

School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147

Aried Eriadi, School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147

School of Pharmaceutical Science (STIFARM) Padang, Indonesia 25147

References

1. Goud, N. S., Prasad, G., & Kumar, S.Phytochemical Analysis, Antibacterial and Antioxidant Capacity of Acetone and Methanol Pericarp Extract of Mangosteen, 2019; 8(11):44-47.
2. Nugraha, S. C. A., Prasetya, T. A., Mursiti., 2016. Isolasi, Identifikasi, Uji Aktivitas Senyawa Flavonoid Sebagai Antibakteri dari Daun Mangga. Indones., J. Chem. Sci. 6(2).
3. Djajadisastra, Joshita et al. Formulasi Gel Topikal Dari Ekstrak Nerii Folium Dalam Sediaan Anti Jerawat. Jurnal Farmasi Indonesia,2009; 4(4): 210-216 .
4. R. H. Pratiwi. Mekanisme Pertahanan Bakteri Patogen Terhadap Antibiotik. J. Berk, 2017; 4(3):418-429.
5. Setiabudy., Rianto. 2007. Farmakologi dan Terapi Ediai 5. Jakarta: Balai Penerbit Fakultas Kedokteran Universitas Indonesia.
6. Cunha, B. A., MD., MACP., 2015. Antibiotic Essentials Fourteenth Edition. The Health Sciences Publisher Panama. ISBN 978-93-5152-850-0.
7. Yodhu, S., Sirikatitham, A., Wattanapiromsaku, C. Validation of LC For The Determination of a-Mangostin In Mangosteen Peel Extract: A Tool For Quality Assessment Of Garcinia Mangostana L. Journal of Chromatographic Science, 2009; 47
8. Putra, I. N. K. Aktivitas Antibakteri Ekstrak Kulit Buah Manggis (Garcinia Mangostana L.) Serta Kandungan Senyawa Aktifnya [Antibacterial Activity of Mangosteen (Garcinia Mangostana L.) Husk Extract, And Its Active Compounds]. Jurnal Teknologi Dan Industri Pangan, 2010; 21(1):1-1.
9. Hutapea, J.R. (1994). Inventaris Tanaman Obat Indonesia. (Jilid Iii). Jakarta: Departemen Kesehatan Republik Indonesia Dan Badan Penelitian Dan Pengembangan Kesehatan.
10. Kumalasari, N. P. R. Aktivitas Antibakteri Ekstrak Etanol Kulit Batang Manggis (Garcinia Mangostana Linn.) Terhadap Bacillus Subtilis Dan Escherichia Coli Atcc 25922. Calyptra, 2013; 2(2):1-10.
11. Sari, G. N. F., & Turahman, T. Aktivitas Antibakteri Ekstrak Dan Fraksi Daun Manggis (Garcinia Mangostana) Terhadap Staphylococcus Aureus Dan Pseudomonas Aeruginosa. In Prosiding Seminar Nasional Unimus, 2018; 1: 2654-3257; 2654-3168.
12. Suhartati, R., Apriyani, F., Virgianti, D. P., & Fathurohman, M. Antimicrobial Activity Test of Mangosteen Leaves Ethanol Extract (Garcinia mangostana Linn) Against Pseudomonas Aeruginosa Bacteria. In Journal Of Physics: Conference Series, 2019; 1179(1):012167 .
13. Melkianus, B., Fatimawali, F., & Sudewi, S. Uji Aktivitas Antibakteri Ekstrak Kulit Buah Manggis (Garcinia Mangostana L.) Terhadap Bakteri Klebsiella Pneumonlae. Pharmacon, 2019; 8(1):88-93.
14. Maliana, Y., Khotimah, S., & Diba, F. Aktivitas Antibakteri Kulit Garcinia Mangostana Linn. Terhadap Pertumbuhan Flavobacterium Dan Enterobacter Dari Coptotermes Curvignathus Holmgren. Protobiont, 2013; 2(1): 7 – 11.
15. Arsana, I. N. Uji Sensitifitas Bakteri Escherichia Coli Terhadap Ekstrak Kulit Buah Manggis (Garcinia Mangostana L.) Secara In-Vitro. 2015; 6(1): 2086-5783 .
16. Valmai, V. R., Choironi, N. A., & Sunarto, S. Aktivitas Antibakteri Ekstrak Etil Asetat Kulit Manggis (Garcinia Mangostana L.) Terhadap Staphylococcus Epidermidis. Acta Pharmaciae Indonesia, 2019; 7(1):36-41.
17. Janardhanan, S., Mahendra, J., Girija, A. S., Mahendra, L., & Priyadharsini, V. Antimicrobial effects of Garcinia mangostana on cariogenic microorganisms. Journal of clinical and diagnostic research: JCDR, 2017; 11(1):ZC19-ZC22.
18. Srikandi, S., & Widhyastini, I. M. Antibakteri Ekstrak Kulit Buah Manggis (Garcinia Mangostana L.). Jurnal Sains Natural, 2017; 4(2):172-179.
19. Permata, P., Kawuri, R., & Darmadi, A. K. Uji Aktifitas Antibakteri Ekstrak Etanol Kulit Buah Manggis (Gracinia Mangostana L.) Terhadap Pertumbuhan Bakteri Escherichia Coli. Simbiosis, 2018; 4(1); 2337-7224.
20. Jacob, D., Vigasini, N., & Iyer, P. R. Antibacterial Activity of Mangosteen (Garcinia Mangostana) Pericarp. World J. Pharm. Res, 2016; 5(9): 1797-1802.
21. Wahyudi, H. E., Ardy, E. S., & Nawawi, A. P. Potensi Hambat Ekstrak Kulit Buah Manggis (Garcinia Mangostana L.) Terhadap Pertumbuhan Enterococcus Faecalis. Medika Kartika: Jurnal Kedokteran Dan Kesehatan, 2019; 2(2):123-134.
22. Tellu, F. Y., Sunarto, S., & Utami, E. D. Aktivitas Antibakteri Ekstrak Etil Asetat Kulit Buah Manggis (Garcinia Mangostana L.) Terhadap Propionibacterium Acnes. Acta Pharmaciae Indonesia, 2019; 7(2):58-67.
23. Jayanto, I., Paputungan, A. N., Lolo, W. A. Aktivitas Antibakteri Dan Analisis KLT-Bioautografi Dari Fraksi Daun Manggis (Garcinia mangostana L.). Pharmacon-Program Studi Farmasi, FMIPA, Universitas Sam Ratulangi, 2019; 8(3) .
24. Soetikno, J. S., Handayani, R., & Rahayu, R. D. Assay For Antimicrobial Activity Of Mangosteen Rind Extracts. Journal Of Innovations In Pharmaceuticals And Biological Sciences, 2016;3(1): 54-60.
25. Sari, R., Pratiwi, L., Apridamayanti, P. Efektivitas SNEDDS Ekstrak Kulit Manggis Terhadap Bakteri P.mirabillis dan S.epidermis Yang Terdapat Pada Ulkus Diabetik. Pharm Sci Res, 2016; 3(3): 2407-2354.
26. Indrianingsih, A. W., Rosyida, V. T., & Ratih, D. In Vitro Study of Antioxidant and Antimicrobial Activities of Garcinia Mangostana L. Peel Extract.In 5th International Conference on Food, Agriculture And Natural Resources (Fanres 2019) (Pp. 152-155). Atlantis Press, 2020; 194.
27. Widyarman, A. S., Lay, S. H., Wendhita, I. P., Tjakra, E. E., Murdono, F. I., & Binartha, C. T. O. Indonesian Mangosteen Fruit (Garcinia Mangostana L.) Peel Extract Inhibits Streptococcus Mutans And Porphyromonas Gingivalis In Biofilms In Vitro. Contemporary Clinical Dentistry, 2019; 10(1):123.
28. Bhat, R. S., & Al-Daihan, S. Antimicrobial Activity of Garcinia Mangostana Using Different Solvents Extracts. International Journal Of Biosciences (Ijb), 2013; 3(10):267-272.
29. Li, Q., & Xu, J. G. Effects of Extraction Solvents on Phytochemicals and Antibacterial Activities of Garcinia Mangostana Pericarp. Asian Journal Of Agriculture And Food Sciences, 2014; 2(4):2321-1571.
30. Octaviani, N. P., Mooduto, L., & Sudirman, A. Antibacterial Potency Of Mangosteen Pericarp Extracts (Garcinia Mangostana L.) Against Fusobacterium Nucleatum. Conservative Dentistry Journal, 2020; 10(2):44-47.
31. Sze Lim, Y., Sze Hui Lee, S., & Chin Tan, B. Antioxidant Capacity and Antibacterial Activity of Different Parts of Mangosteen (Garcinia Mangostana Linn.) Extracts. Fruits, 2013; 68(6) .
32. Davis, W. W., & Stout, T. R. (). Disc plate method of microbiological antibiotic assay. Journal of microbiology, 1971; 22(4):659-665.
33. Robinson, T., 1995. Kandungan Organik Tumbuhan Tinggi. Edisi 6. ITB Press, Bandung.
34. Harbone, B. J., 1987, Metode Fitokimia: Penuntun Cara Modern Menganalisis Tumbuhan. Penerjemah: Kosasih Padmawinata dan Iwang Soediro, ITB, Bandung.
35. Cowan, M. M. Plant Product as Microbial Agent, Clinical Microbial Review, 1999; 12:564-582.
36. Ajizah, A. Sensitivitas Salmonella thypimurium Terhadap Ekstrak Daun Psidium guajava L., J. Bioscientiae,2004; 1(1):31-38.
37. Madduluri, S., Rao, K. B., Sitaram, B. In Vitro Evaluation of Antibacterial Activity of Five Indigenous Plants Extracts Against Five Bacteria Pathogens of Humans, International Journal of Pharmacy and Pharmaceutical Sciences, 2013; 5:679-684.
38. Jawetz, M., Adelberg’s., 1996, Medical Microbiology, Edisi 20, Alih Bahasa: Edi Nugroho., Maulany, R. F., Penerbit Buku Kedokteran ECG., Jakarta.
39. Prescott, L, M., Harley, J. P., Klien, D. A., 2005, Microbiology, Edisi 6, Mc-Graw Hill, New York.
40. Widhyastini, I. M. Pengaruh Suhu Pengeringan Kulit Bagian Luar Dan Bagian Dalam Manggis (Gracinia Mangostana, L.) Terhadap Kandungan Proksimat, Alkaloid Dan Flavonoid. Jurnal Sains Natural, 2017; 3(2):193-200.
41. Jawetz, E., Melnick, J. L., Adelberg, E. A., 2005. Mikrobiologi Kedokteran. Buku 1. Penerbit Salemba Medika. Jakarta.
42. Meilina, N. E., Hasanah, A. N. Review Artikel: Aktivitas Antibakteri Ekstrak Kulit Buah Manggis (Grachinia mangostana L.) Terhadap Bakteri Penyebab Jerawat. Julnal Farmaka.2018; 16(2):322-328

Published

2021-02-15

How to Cite

Andani, R., Fajrina, A., Asra, R., & Eriadi, A. (2021). Antibacterial Activity Test of Mangosteen Plants (Garcinia Mangostana L.): A Review. Asian Journal of Pharmaceutical Research and Development, 9(1), 164–171. https://doi.org/10.22270/ajprd.v9i1.927

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