A Review: Traditional Use, Phytochemical and Pharmacological Review of Red Betel Leaves (Piper Crocatum Ruiz & Pav)
DOI:
https://doi.org/10.22270/ajprd.v9i1.926Keywords:
Red betel leaf (Piper crocatum Ruiz & Pav); Traditional Use; Phytochemicals; pharmacological activityAbstract
Red betel leaf (Piper crocatum Ruiz & Pav) is a plant that grows in tropical areas and was previously known as an ornamental plant, but was later used as a medicinal plant. The use of red betel leaf (Piper crocatum Ruiz & Pav) is traditionally beneficial in curing diseases such as thrush and toothache. Meanwhile, red betel leaf decoction, which is antiseptic, can act as a mouthwash, prevent bad breath and eliminate body odor. From chromatography, it is known that red betel leaves contain flavonoids, polyphenolic compounds, tannins, and essential oils. In the use of red betel leaves, it is widely used to get rid of body odor, vaginal discharge, ulcer, fatigue, muscle aches, and to smoothen the skin, as well as for itchy, red eye cleansers, and canker sore. Red betel leaves decoction is also believed to be able to eliminate bad breath in the mouth if used as a mouthwash.
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References
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35. Ali I, et al. In vitro antifungal activity of hydroxychavicol isolated from Piper betle L. Annals of Clinical Microbiology and Antimicrobials. 2010; 9 (1): 7.
36. Hertiani T, Pratiwi SUT, Irianto IDK, Adityaningrum D, Pranoto B. Effect of Indonesian medicinal plants essential oils on Streptococcus mutant’s biofilm. MFI. 2011; 22 (3): 174-81.
37. Wicaksono BD, et al. Antiproliferative effect of the methanol extract of Piper crocatum Ruiz & Pav. leaves on human breast (T47D) cells in-vitro. Trop. J. Pharm. Res. 2009; 8(4):345-52.
38. Rahmawati IS, Ciptati. Isolation of antioxidant compounds from red betel leaves (Piper crocatum). Proceedings of the National Symposium on Learning and Science Innovation, Bandung-Indonesia; 2011:327-33.
39. Khalaf NA, Shakya AK, Al-Othman A, El-Agbar Z, Farah H. Antioxidant activity of some common plants. J.J. Biol Tour. 2008; 32(1):51-5.
2. Chaveerach A, Mokkamul P, Sudmoon R, Tanee T.Ethnobotany of the genus Piper (Piperaceae) in Thailand. Ethnobotany Research & Applications. 2006; 4: 223-31.
3. Jones SB, Luchsinger AE. Plant systematics, 2nd Ed., New York: McGraw-Hill Publishing Co, USA; 1986.
4. Backer CA, Bakhuizen RC Vd Brink. Flora of Java, Vol. 1, Groningen: NVP. Noordhoff; 1965.
5. Quijano-Abril MA, Callejas-Posada R, MirandaEsquivel DR. Areas of endemism and distribution patterns for neotropical Piper species (Piperaceae). J. Biogeogr. 2006; 33:1266-78.
6. Damanhouri ZA, Ahmad A. A Review on therapeutic potential of Piper nigrum L. (Black Pepper): The king of spices. Medicinal & Aromatic Plants. 2014; 3(3):1-6.
7. Bhalerao SA, et al. Phytochemistry, pharmacological profile and therapeutic uses of Piper betle linn. – an overview. Journal of Pharmacognosy and Phytochemistry. 2013; 1(2):10-9.
8. Dhanalakshmi D, Umamaheswari S, Balaji D, Santhanalakshmi R, and Kavimani S. Phytochemistry and pharmacology of Piper longum: A systematic review. World Journal of Pharmacy and Pharmaceutical Sciences. 2017; 6 (1): 381-98.
9. Nahak G, Sahu RK. Phytochemical evaluation and antioxidant activity of Piper cubeba and Piper nigrum. Journal of Applied Pharmaceutical Science. 2011; 1(8):153-7.
10. Macbride JF, Dahlgreen BE. Flora of Peru, part II, Chicago: USA, 1936: 155.
11. Safithri M, Fahma F. Potency of Piper crocatum decoction as an antihyperglycemic in rat strain sprague dawley. Journal of Biosciences. 2008; 15 (1): 45-8.
12. Sudewo, B. (2005) Eradicate Diseases with Red Betel Yogyakarta: PT Agromedia Pustaka.
13. Suhono, BJ, Yuzammi., Sugiarti., Handayani, T., (2010). Encyclopedia of Flora. (Edition V). Jakarta: Publisher PT. Kharisma Ilmu
14. Agarwal T, Singh R, Shukla AD, Waris I, Gujrati A. Comparative analysis of antibacterial activity of four varieties of Piper betel. Advances in Applied Science Research 2012; 3(2):698-705.
15. Radhika K, Kumaravel B, Thamizhiniyan V, Subramanian S. Biochemical evaluation of the antidiabetic activity of Piper betel leaf extract in alloxan induction of diabetic rats. Asian J. Research Chem 2013; 6(1):76-82.
16. Tawan CS, Ipor IB, Fashihuddin BA, Sani H. “Brief description of the wild piper (Piperaceae) from the crocker range, Sabah” ASEAN Review of Biodiversity and Environment Conservation (ARBEC) 2002, 1-11. (Google doc) art 6Julysep02.
17. John D. One hundred useful raw medicines from the kani tribe of the forest division of Trivandrum, Kerala, India. Int J Crude Drug Res. 1984; 22 (1):17-39.
18. Anonymous “Indian Wealth” Raw Materials, Ph-Re” Vol VIII, New Delhi, National Institute of Communication and Information Science Resources (NISCAIR), CSIR, 2005.
19. Saini, S., Anju, D., and Sanju, N. Study Pharmacognostic and Phytochemical of Betel Betel Leaf. International Journal of Pharmacy and Pharmaceutical Sciences. 2016; 8(5):222- 226.
20. Saxena, M., Naveen, K, K., Priyanka, S., Kodakandla, V, S., and Santosh, K, S. Antimicrobial Activity and Chemical Composition of Leaf Oil in Two Varieties Piper betle From Northern Planto f India. Journal of Scientific & Industrial Research. 2014; 73:95-99.
21. Patil, R, S., Pooja, M, H., Kiran, V, S., Pooja, P, K., and Ranjeet, R, D. Potential of Phytochemicals in Vitro Antimicrobial Activity of Piper betel Linn. Leaf Extract. Journal of Chemical and Pharmaceutical Research. 2015; 7(5):1095-1101.
22. Kaveti, B., Lisa, T., Tan, S, K., and Mirza, B. Antibacterial Activity of Piper Betel Leaves. International Journal of Pharmacy Teaching & Practice. 2011; 2(3):129-132.
23. Fitriyani A, Winarti L, Muslichah S, Nuri. Anti-inflammatory test of methanol extract of red betel leaf (Piper crocatum Ruiz & Pav.) On white rats. Traditional Medicine Magazine. 2011; 16 (1):34-42.14.
24. Vagashiya Y, Nair R, Chanda S.Investigation of some piper species for anti-bacterial and anti-inflammatory property. Inter. J. Pharmacol. 2007; 3 (5): 403-5.
25. Parise-Filho R, et al. The anti-inflammatory activity of dillapiole and some semisynthetic analogues. Pharm. Biol. 2011; 49 (11): 1173-9.
26. Rodriguez SD, Baroni S, Svidzinski AE, BersaniAmado CA, Cortez DA. Antiinflammatory activity of extract, fractions and amides from the leaves of Piper ovatum Vahl (piperaceae). J. Ethnopharmacol. 2008; 116(3):569-73.
27. Agnihotri S, Wakode S, Agnihotri A. An overview on anti-inflammatory properties and chemoprofiles of plants used in traditional medicine. Indian journal of natural products Resources, 2010; 1(2):150-67.
28. Juliantina F, Citra DA, Nirwani B, Nurmasitoh T, Bowo ET. Benefits of red betel (Piper crocatum) as an antibacterial agent against gram-positive and gram-negative bacteria. JKKI. 2009; 1(1):12-20.
29. Mutmainnah A. Effect of red betel leaf extract (Piper crocatum) on the histopathological features of skin incision wounds of white rats infected with Staphylococcus aureus. FKH scientific work, Airlangga University, Surabaya; 2013.
30. Rizky OR. In vitro test for the antifungal activity of the ethanol extract of red betel leaf (Piper crocatum Ruiz & Pav.) Against Candida albicans ATCC 10231. FK scientific work, UMS, Surakarta; 2012.
31. Dhewayani IN. The effectiveness of red betel leaf (Piper crocatum) infusion on the growth of Candida albicans. FKG scientific work, Airlangga University, Surabaya; 2012.40. Oktaviani D. Comparative test of the effectiveness of red betel leaf extract (Piper crocatum) with zinc pyrithione 1% on the growth of pityrosporum ovale in dandruff patients. FK scientific work, Diponegoro University, Semarang; 2012.
32. Navickiene HMD, et al. Composition and anti-fungal activity of essential oils from Piper aduncum, Piper arboreum and Piper tuberculatum. Quim.Nova. 2006; 29(3):467-70.
33. Navickiene HMD, et al. Composition and antifungal activity of essential oils from piper aduncum, Pi-per arboretum and Piper tuberculatum. Quim.Nova. 2006; 2 (3):467-70.
34. De Campos MP, Filho VC, Da Silva RZ, Yunes RA, Zacchino S, Juares S, Bella Cruz RC, Bella Cruz A.Evaluation of antifungal activity of Piper solmsianum C. DC. var. solmsianum (Piperaceae). Biol. Pharm. Bull. 2005; 28(8):1527-30.
35. Ali I, et al. In vitro antifungal activity of hydroxychavicol isolated from Piper betle L. Annals of Clinical Microbiology and Antimicrobials. 2010; 9 (1): 7.
36. Hertiani T, Pratiwi SUT, Irianto IDK, Adityaningrum D, Pranoto B. Effect of Indonesian medicinal plants essential oils on Streptococcus mutant’s biofilm. MFI. 2011; 22 (3): 174-81.
37. Wicaksono BD, et al. Antiproliferative effect of the methanol extract of Piper crocatum Ruiz & Pav. leaves on human breast (T47D) cells in-vitro. Trop. J. Pharm. Res. 2009; 8(4):345-52.
38. Rahmawati IS, Ciptati. Isolation of antioxidant compounds from red betel leaves (Piper crocatum). Proceedings of the National Symposium on Learning and Science Innovation, Bandung-Indonesia; 2011:327-33.
39. Khalaf NA, Shakya AK, Al-Othman A, El-Agbar Z, Farah H. Antioxidant activity of some common plants. J.J. Biol Tour. 2008; 32(1):51-5.
Published
2021-02-15
How to Cite
Suri, M. A., Azizah, Z., & Asra, R. (2021). A Review: Traditional Use, Phytochemical and Pharmacological Review of Red Betel Leaves (Piper Crocatum Ruiz & Pav). Asian Journal of Pharmaceutical Research and Development, 9(1), 159–163. https://doi.org/10.22270/ajprd.v9i1.926
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Section
Review Articles
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