Formulation and Evaluation of Micro Emulsion for the Treatment of Bacterial Meningitis
DOI:
https://doi.org/10.22270/ajprd.v13i4.1586Abstract
The aim of the present study was to prepare antibacterial drug loaded microemulsion. Antibactrial drug loaded Microemulsion were prepared by water titration method. The microemulsions were further characterized for particle size, zeta potential, pH, viscosity, drugcontent, and in vitro drug release behavior. The results revealed that this method is reproducible, more feasible and led to the entrapment of drug with an expected sustained release. The nanoparticle precipitated was with particle size of 176.8 nm, zeta potential of −29 mV, pH is determined in 4.5 to 6.5 and Viscouse in flow. The Drug content was noted was 83.95%. In vitro release was about 32.16% release in 1 h. When the regression coefficient values were compared, it was observed that ‘R2 ’ values of first order was maximum i.e. 0.9644 hence indicating drug release from formulation was found to follow zero order release kinetics. Antibactrial drug-loaded Microemulsion may be a good choice for the improvement of bioavailability and reduction in toxicity.
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Alam MI, Beg S, Samad A, Baboota S, Kohli K, Ali J, Ahuja A, Akbar M. Strategy for effective brain drug delivery. European journal of pharmaceutical sciences. 2010 Aug 11;405):385-403.
Ballabh P, Braun A, Nedergaard M. The blood–brain barrier: an overview: structure, regulation, and clinical implications. Neurobiology of disease. 2004 Jun 1;16(1):1-3.
Kabanov AV, Batrakova EV. Polymer nanomaterials for drug delivery across the blood brain barrier. InNeuroimmune pharmacology 2016 Dec 23 (pp. 847-868). Cham: Springer International Publishing.
Pardridge WM. Blood–brain barrier delivery. Drug discovery today. 2007 Jan 1;12(1-2):54-61.
Pardridge WM. The blood-brain barrier and neurotherapeutics. NeuroRx. 2005 Jan;2(1):1.
Pardridge WM. The blood-brain barrier: bottleneck in brain drug development. NeuroRx. 2005 Jan; 2:3-14.
Warnken ZN, Smyth HD, Watts AB, Weitman S, Kuhn JG, Williams III RO. Formulation and device design to increase nose to brain drug delivery. Journal of Drug Delivery Science and Technology. 2016 Oct 1; 35:213-22.
Krames E, Buchser E, Hassenbusch SJ, Levy R. Future trends in the development of local drug delivery systems: intraspinal, intracerebral, and intraparenchymal therapies. Neuromodulation: Technology at the Neural Interface. 1999 Apr 1;2(2):133-48.
Krames E, Buchser E, Hassen Busch SJ, Levy R. Future trends in the development of local drug delivery systems: intraspinal, intracerebral, and intraparenchymal therapies. Neuromodulation: Technology at the Neural Interface. 1999 Apr 1;2(2):133-48.
Froelich A, Osmałek T, Jadach B, Puri V, Michniak-Kohn B. Microemulsion-based media in nose-to-brain drug delivery. Pharmaceutics. 2021 Feb 2;13(2):201.
Szvalb AD, Raad II, Weinberg JS, Suki D, Mayer R, Viola GM. Ommaya reservoir-related infections: clinical manifestations and treatment outcomes. Journal of Infection. 2014 Mar 1;68(3):216-24.
Lau JC, Kosteniuk SE, Walker T, Iansavichene A, Macdonald DR, Megyesi JF. Operative complications with and without image guidance: a systematic review and meta-analysis of the Ommaya reservoir literature. World Neurosurgery. 2019 Feb 1; 122:404-14.
Hitt JM, de Leon-Casasola OA. Complications of intrathecal drug delivery systems. Techniques in Regional Anesthesia and Pain Management. 2011 Oct 1;15(4):162-6.
Gao X, Yue Q, Liu Y, Fan D, Fan K, Li S, Qian J, Han L, Fang F, Xu F, Geng D. Image-guided chemotherapy with specifically tuned blood brain barrier permeability in glioma margins. Theranostics. 2018 Apr 30;8(11):3126.
Lin YL, Wu MT, Yang FY. Pharmacokinetics of doxorubicin in glioblastoma multiforme following ultrasound-Induced blood-brain barrier disruption as determined by microdialysis. Journal of Pharmaceutical and Biomedical Analysis. 2018 Feb 5; 149:482-7.
Chen Y, Liu L. Modern methods for delivery of drugs across the blood–brain barrier. Advanced drug delivery reviews. 2012 May 15;64(7):640-65.
Hoar TP, Schulman JH. Transparent water-in-oil dispersions: the oleopathic hydro-micelle. Nature. 1943 Jul 24;152(3847):102-3.
Schulman JH, Stoeckleins W, Prince LM. Mechanism of formation and structure of micro emulsions by electron microscopy. The Journal of physical chemistry. 1959 Oct;63(10):1677-80.
Attwood D. Microemulsions. InColloidal drug delivery systems 2014 Jul 22 (pp. 43-84). CRC Press.
Shinoda K, Lindman B. Organized surfactant systems: microemulsions. Langmuir. 1987 Mar;3(2):135-49.
Prince LM. A theory of aqueous emulsions I. Negative interfacial tension at the oil/water interface. Journal of colloid and interface science. 1967 Feb 1;23(2):165-73.
Shinoda K, Kunieda H. Conditions to produce so-called microemulsions: Factors to increase the mutual solubility of oil and water by solubilizer. Journal of Colloid and Interface Science. 1973 Feb 1;42(2):381-7.
Trösken ER, Fischer K, Völkel W, Lutz WK. Inhibition of human CYP19 by azoles used as antifungal agents and aromatase inhibitors, using a new LC–MS/MS method for the analysis of estradiol product formation. Toxicology. 2006 Feb 15;219(1-3):33-40.
Madani S, Barilla D, Cramer J, Wang Y, Paul C. Effect of terbinafine on the pharmacokinetics and pharmacodynamics of desipramine in healthy volunteers identified as cytochrome P450 2D6 (CYP2D6) extensive metabolizers. The Journal of Clinical Pharmacology. 2002 Nov;42(11):1211-8.
Yan J, Wang X, Chen S. Systematic review of severe acute liver injury caused by terbinafine. International journal of clinical pharmacy. 2014 Aug;36:679-83.
Acharya A, Moulik SP, Sanyal SK, Mishra BK, Puri PM. Physicochemical investigations of microemulsification of coconut oil and water using polyoxyethylene 2-cetyl ether (Brij 52) and isopropanol or ethanol. Journal of colloid and interface science. 2002 Jan 1;245(1):163-70.
Kaur G, Saifi A, Kumar K, Teotia D. Development and Evaluation of Micro Emulsion Formulations of Nebivolol for Solubility Enhancement. Journal of Drug Delivery & Therapeutics. 2021 Sep 1;11(5).
Thakkar HP, Patel AA, Chauhan NP. Formulation and optimization of mucoadhesive microemulsion containing mirtazapine for intranasal delivery. journal of thermal analysis and calorimetry. 2014;5(1):25-32.
Darekar AB, Jaiswal PL, Saudagar RB. Design Development and Evaluation of Duloxetine Hydrochloride Microemulsion for Intranasal Delivery. Eur J of Biomedand Pharma Sci. 2018;5(2):679-84.
Vicentini FT, Vaz MM, Fonseca YM, Bentley MV, Fonseca MJ. Characterization and stability study of a water-in-oil microemulsion incorporating quercetin. Drug Development and Industrial Pharmacy. 2011 Jan 1;37(1):47-55.
Tungadi R, Jusuf H. Formulation And Characterization Of Astaxanthin Loaded Self Nano Emulsifying Drug Delivery System (SNEDDS). Universal Journal of Pharmaceutical Research. 2022 Jul 15.
Mutimer MN, Riffkin C, Hill JA, Glickman ME, Cyr GN. Modern ointment base technology II. Comparative evaluation of bases. Journal of the American Pharmaceutical Association. 1956 Apr;45(4):212-8.
Fatima Z, Shahidulla SM. Formulation, optimization and evaluation of hexadecanoic acid phytosomal gel for anti-fungal activity. International Journal of Pharmaceutical Sciences and Research. 2023;14(1):519-29.
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