Oral Fast Dissolving Film: A Review

Authors

  • Deshmukh P. Nishant Vidyabharati College of Pharmacy, Amravati
  • Dr. Nishan N. Bobade Vidyabharati College of Pharmacy, Amravati
  • Dr. Vikrant P. Wankhade Vidyabharati College of Pharmacy, Amravati
  • Dr. Sandeep C. Atram Vidyabharati College of Pharmacy, Amravati
  • Dr. Shrikant D. Pande Vidyabharati College of Pharmacy, Amravati
  • Khedkar S. Anuradha Vidyabharati College of Pharmacy, Amravati
  • Patil A. Mahendra Vidyabharati College of Pharmacy, Amravati

DOI:

https://doi.org/10.22270/ajprd.v13i2.1553

Abstract

Fast-dissolving films are becoming a popular alternative to fast-dissolving tablets. These films dissolve quickly when they come in contact with a wet surface, like the tongue, and can be taken without needing extra liquid. This makes them convenient and helps patients stick to their treatment, especially children, older adults, and people who have trouble swallowing pills or fear choking. Because the drug in these films is absorbed directly into the bloodstream through the mouth, it avoids problems in the digestive system and bypasses the first-pass effect (which happens when the liver breaks down the drug before it reaches the rest of the body). This type of formulation is gaining popularity in over-the-counter products in the U.S. for things like pain relief and motion sickness.

 

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Author Biographies

Deshmukh P. Nishant, Vidyabharati College of Pharmacy, Amravati

Vidyabharati College of Pharmacy, Amravati

Dr. Nishan N. Bobade, Vidyabharati College of Pharmacy, Amravati

Vidyabharati College of Pharmacy, Amravati

Dr. Vikrant P. Wankhade, Vidyabharati College of Pharmacy, Amravati

Vidyabharati College of Pharmacy, Amravati

Dr. Sandeep C. Atram, Vidyabharati College of Pharmacy, Amravati

Vidyabharati College of Pharmacy, Amravati

Dr. Shrikant D. Pande, Vidyabharati College of Pharmacy, Amravati

Vidyabharati College of Pharmacy, Amravati

Khedkar S. Anuradha, Vidyabharati College of Pharmacy, Amravati

Vidyabharati College of Pharmacy, Amravati

Patil A. Mahendra, Vidyabharati College of Pharmacy, Amravati

Vidyabharati College of Pharmacy, Amravati

References

Pacheco MS, Barbieri D, da Silva CF, de Moraes MA. A review on orally disintegrating films (ODFs) made from natural polymers such as pullulan, maltodextrin, starch, and others. International journal of biological macromolecules. 2021 May 1; 178:504-13.

Reddy TU, Reddy KS, Manogna K, Thyagaraju K. A detailed review on fast dissolving oral films. Journal of Pharmaceutical Research. 2018;8(06).

Gavaskar B, Kumar SV, Sharan G, Rao YM. Overview on fast dissolving films. International Journal of Pharmacy and Pharmaceutical Sciences. 2010;2(3):29-33

Bhyan B, Jangra S, Kaur M, Singh H. Orally fast dissolving films: innovations in formulation and technology. Int J Pharm Sci Rev Res. 2011 Jul;9(2):9-15.

Bala R, Sharma S. Formulation optimization and evaluation of fast dissolving film of aprepitant by using design of experiment. Bulletin of Faculty of Pharmacy, Cairo University. 2018 Dec 1;56(2):159-68.

Mahajan A, Chhabra N, Aggarwal G. Formulation and characterization of fast dissolving buccal films: A review. Der Pharm Lett. 2011;3(1):152-65.

Harris D, Robinson JR. Drug delivery via the mucous membranes of the oral cavity. Journal of pharmaceutical sciences. 1992 Jan 1;81(1):1-0.

Seager H. Drug-delivery products and the Zydis fast-dissolving dosage form. Journal of pharmacy and pharmacology. 1998 Apr;50(4):375-82.

Gauri S, Kumar G. Fast dissolving drug delivery and its technologies. The pharma innovation. 2012 Apr 1;1(2, Part A):34.

Dnyaneshwar HR, Wale KK, Sayyed SF, Chaudhari SR. Oro-dispersible film dosage form: A review. World Journal of Pharmaceutical Research. 2014 of venlafaxine hydrochloride fast dissolving oral films. Saudi pharmaceutical journal. 2020 Nov 1;28(11):1374-82.

Jyoti A, Gurpreet S, Seema S, Rana AC. Fast dissolving films: A novel approach to oral drug delivery. Int Res J Pharm. 2011 Dec 1;2(12):69-74.

Sastry SV, Nyshadham JR, Fix JA. Recent technological advances in oral drug delivery–a review. Pharmaceutical science & technology today. 2000 Apr 1;3(4):138-45.

Vondrak B, Barnhart S. Dissolvable films: dissolvable films for flexible product format in drug delivery. Pharmaceutical Technology. 2008 Apr 1;2008(1).

Bala R, Pawar P, Khanna S, Arora S. Orally dissolving strips: A new approach to oral drug delivery system. International journal of pharmaceutical investigation. 2013 Apr;3(2):67.

Shukla D, Chakraborty S, Singh S, Mishra B. Mouth dissolving tablets I: An overview of formulation technology. Scientia Pharmaceutica. 2009 Jun;77(2):309-26.

Kulkarni N, Kumar L, Sorg A, inventors; Warner Lambert Co LLC, assignee. Fast dissolving orally consumable films containing an antitussive and a mucosa coating agent. United States patent application US 10/423,735. 2003 Nov 6.

Ali S, Quadir A. High molecular weight povidone polymer-based films for fast dissolving drug delivery applications. Drug Delivery Technology. 2007;7(6):36-43.

Sohi H, Sultana Y, Khar RK. Taste masking technologies in oral pharmaceuticals: recent developments and approaches. Drug development and industrial pharmacy. 2004 Jan 1;30(5):429-48.

Nair SS, Padamanabhan R and Sreena K: Development and Evaluation of fast dissolving oral thin film containing prochlorperazine maleate. Eur J Pharm Medical Res 2016; 3(1): 379-84.

Soni MM and Patel KR: Formulation and evaluation of fast dissolving film of lurasidone HCl. Int J Pharm Res Bio Sci 2016; 5(2): 101-23.

Chougule PC: Design and evaluation of formulated mouth dissolving film ofdomperidone and study the effect of concentration of polymers on drug release. Asian J Pharm 2017; 11: S846-S853

Bhowmik D, Chiranjib B, Krishnakanth P, Chandira RM. Fast dissolving tablet: an overview. Journal of chemical and pharmaceutical research. 2009;1(1):163-77.

Raju S, Reddy PS, Kumar VA, Deepthi A, Reddy KS, Reddy PM. Flash release oral films of metoclopramide hydrochloride for pediatric use: Formulation and in-vitro evaluation. J. Chem. Pharm. Res. 2011;3(4):636-46

Verma P, Thakur AS, Deshmukh K, Jha AK, Verma S. Routes of drug administration. International Journal of Pharmaceutical Studies and Research. 2010 Jul;1(1):54-9.

Ali S, Quadir A. High molecular weight povidone polymer-based films for fast dissolving drug delivery applications. Drug Delivery Technology. 2007;7(6):36-43.

Dahiya M, Saha S, Shahiwala AF. A review on mouth dissolving films. Current drug delivery. 2009 Oct 1;6(5):469-76.

Corniello C. Quick dissolving strips: from concept to commercialization. Drug Del. Technol. 2006;6(2):68-71.

Gopal TS. Testing of packaging materials. InQuality Analysis and Packaging of Seafood Products 2025 Jan 1 (pp. 383-405). Academic Press.

Mashru RC, Sutariya VB, Sankalia MG, Parikh PP. Development and evaluation of fast-dissolving film of salbutamol sulphate. Drug development and industrial pharmacy. 2005 Jan 1;31(1):25-34.

Felton LA. Aqueous polymeric coatings for pharmaceutical dosage forms. CRC Press; 2016 Sep 19.

Dinge A, Nagarsenker M. Formulation and evaluation of fast dissolving films for delivery of triclosan to the oral cavity. AapsPharmscitech. 2008 Jun;9:349-56.

Yehia SA, El-Gazayerly ON, Basalious EB. Fluconazole mucoadhesive buccal films: in vitro/in vivo performance. Current drug delivery. 2009 Jan 1;6(1):17-27.

Satyanarayana DA, Keshavarao KP. Fast disintegrating films containing anastrozole as a dosage form for dysphagia patients. Archives of pharmacal research. 2012 Dec; 35:2171-82.

ElMeshad AN, ElHagrasyAS. Characterization and optimization of orodispersiblemosapride film formulations. AAPS PharmSciTech, 2011; 12(4): 1384–1392.

Patel RS, Poddar SS. Development and characterization of mucoadhesive buccal patches of salbutamol sulphate. Current drug delivery. 2009 Jan 1;6(1):140-4.

Mukherjee D, Bharath S. Design and characterization of double layered mucoadhesive system containing bisphosphonate derivative. International Scholarly Research Notices. 2013;2013(1):604690.

Choudhary DR, Patel VA, Chhalotiya UK, Patel HV, Kundawala AJ. Development and characterization of pharmacokinetic parameters of fast-dissolving films containing levocetirizine. Scientia pharmaceutica. 2012 Jul 22;80(3):779.

Published

2025-04-15

How to Cite

Deshmukh P. Nishant, Dr. Nishan N. Bobade, Dr. Vikrant P. Wankhade, Dr. Sandeep C. Atram, Dr. Shrikant D. Pande, Khedkar S. Anuradha, & Patil A. Mahendra. (2025). Oral Fast Dissolving Film: A Review . Asian Journal of Pharmaceutical Research and Development, 13(2), 148–156. https://doi.org/10.22270/ajprd.v13i2.1553

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