Emerging Role of Microsponges in the Treatment of Psoriasis: A Comprehensive Review

Authors

  • Kokate S.Tanvi Vidyabharti College of Pharmacy, Amravati
  • Dr. Vikrant P. Wankhade Vidyabharti College of Pharmacy, Amravati
  • Dr. Shrikant D. Pande Vidyabharti College of Pharmacy, Amravati
  • Dr. Sandeep C. Atram Vidyabharti College of Pharmacy, Amravati
  • Dr. Nishan N. Bobade Vidyabharti College of Pharmacy, Amravati
  • VikramV.Bhoyar Vidyabharti College of Pharmacy, Amravati
  • Neha S. Ghogare Vidyabharti College of Pharmacy, Amravati

DOI:

https://doi.org/10.22270/ajprd.v13i3.1559

Abstract

Psoriasis is a chronic autoimmune inflammatory skin disorder characterised by red, scaly, and itchy plaques, resulting from an accelerated turnover of skin cells due to an overactive immune response. Although various treatment options are available, ranging from topical agents to systemic therapies and biologics, they are often associated with limitations such as poor drug penetration, systemic side effects, and reduced patient adherence. Recent advances in drug delivery, particularly microsponge-based systems, offer a novel approach to overcoming these challenges. Microsponges enable controlled drug release, improved skin retention, and enhanced therapeutic efficacy. This review highlights the potential of microsponge technology in the management of psoriasis and discusses its advantages over conventional formulations.

 

 

 

Downloads

Download data is not yet available.

Author Biographies

Kokate S.Tanvi, Vidyabharti College of Pharmacy, Amravati

Vidyabharti College of Pharmacy, Amravati

Dr. Vikrant P. Wankhade, Vidyabharti College of Pharmacy, Amravati

Vidyabharti College of Pharmacy, Amravati

Dr. Shrikant D. Pande, Vidyabharti College of Pharmacy, Amravati

Vidyabharti College of Pharmacy, Amravati

Dr. Sandeep C. Atram, Vidyabharti College of Pharmacy, Amravati

Vidyabharti College of Pharmacy, Amravati

Dr. Nishan N. Bobade, Vidyabharti College of Pharmacy, Amravati

Vidyabharti College of Pharmacy, Amravati

VikramV.Bhoyar, Vidyabharti College of Pharmacy, Amravati

Vidyabharti College of Pharmacy, Amravati

Neha S. Ghogare, Vidyabharti College of Pharmacy, Amravati

Vidyabharti College of Pharmacy, Amravati

References

Sala M, Elaissari A, Fessi H. Advances in psoriasis physiopathology- gy and treatments: Up to date of mechanistic insights and perspectives of novel therapies based on innovative skin drug delivery systems (ISDDS). J Control Release 2016; 239: 182-202.

Lowes MA, Suárez-Fariñas M, Krueger JG. Immunology of psoriasis. Annu Rev Immunol 2014; 32: 227-55.

Danielsen K, Olsen AO, Wilsgaard T, Furberg AS. Is the prevalence of psoriasis increasing? A 30-year follow-up of a population-based cohort. Br J Dermatol 2013; 168(6): 1303-10.

Mehlis SL, Gordon KB. The immunology of psoriasis and biologic immunotherapy. J Am Acad Dermatol 2003; 49(2)(Suppl.): S44- 50.

Fitch E, Harper E, Skorcheva I, Kurtz SE, Blauvelt A. Pathophysi- ology of psoriasis: recent advances on IL-23 and Th17 cytokines. Curr Rheumatol Rep 2007; 9(6): 461-7.

Eberle FC, Brück J, Holstein J, Hirahara K, Ghoreschi K. Recent advances in understanding psoriasis. F1000 Res 2016; 5: 5.

Pradhan M, Singh D, Singh MR. Influence of selected variables on fabrication of Triamcinolone acetonide loaded solid lipid nanoparticles for topical treatment of dermal disorders. Artif Cells Nano- med Biotechnol 2016; 44(1): 392-400.

Takeshita J, Gelfand JM, Li P, et al. Psoriasis in the US Medicare population: prevalence, treatment, and factors associated with bio- logic use. J Invest Dermatol 2015; 135(12): 295563.

Gupta R, Debbaneh MG, Liao W. Genetic epidemiology of psoria- sis. Curr Dermatol Rep 2014; 3(1): 61-78.

Gudjonsson JE, Elder JT. Psoriasis: epidemiology. Clin Dermatol 2007; 25(6): 535-46.

Icen M, Crowson CS, McEvoy MT, Dann FJ, Gabriel SE, Maradit Kremers H. Trends in incidence of adult-onset psoriasis over three decades: a population-based study. J Am Acad Dermatol 2009; 60(3): 394-401.

Bhatia A, Singh B, Wadhwa S, Raza K, Katare OP. Novel phos- pholipid-based topical formulations of tamoxifen: evaluation for antipsoriatic activity using mouse-tail model. Pharm Dev Technol 2014; 19(2): 160-3.

M.A. Menter, A.W. Armstrong, K.B. Gordon, J.J. Wu, Common and Not-So- Common Comorbidities of Psoriasis 37 (2018) 49–52, https://doi.org/10.12788/ j.sder.2018.011.

C.G. Helmick, J.J. Sacks, J.M. Gelfand, B. Bebo, H. Lee-han, T. Baird, C. Bartlett, Psoriasis and psoriatic arthritis, AMEPRE 44 (2019) 424–426, https://doi.org/ 10.1016/j.amepre.2013.01.004.

Rendon, K. Sch¨ akel, Psoriasis pathogenesis and treatment, Int. J. Mol. Sci. 20 (2019) 1475,

C.E. Capitena Young, M.Y. Kahook, L.K. Seibold, Novel drug delivery systems for the treatment of glaucoma, Curr. Ophthalmol. Rep. (2019) 4874–4880, https:// doi.org/10.1007/s40135-019-00210-3, 06.

K. Asumalahti, M. Ameen, S. Suomela, E. Hagforsen, G. Micha¨ elsson, J. Evans, M. Munro, C. Veal, M. Allen, J. Leman, A.D. Burden, B. Kirby, M. Connolly, C.E. M. Griffiths, R.C. Trembath, J. Kere, U. Saarialho-Kere, J.N.W.N. Barker, Genetic analysis of PSORS1 distinguishes guttate psoriasis and palmoplantar pustulosis, J. Invest. Dermatol. 120 (2003) 627–632 .

T.T. Koca, A short summary of clinical types of psoriasis, North. Clin. Istanbul. 3 (2016) 79–82.

S.K. Raychaudhuri, E. Maverakis, S.P. Raychaudhuri, Diagnosis and classification of psoriasis, Autoimmun. Rev. 13 (2014) 490–495, https://doi.org/10.1016/j. autrev.2014.01.008.

Fouéré S, Adjadj L, Pawin H. How patients experience psoriasis: results from a European survey. J EurAcad Dermatol Venereol 2005; 19(Suppl. 3): 2-6.

Dogra S, Yadav S. Acitretin in psoriasis: an evolving scenario. Int J Dermatol 2014; 53(5): 525-38.

Montesinos MC, Desai A, Delano D, et al. Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrex- ate and its analog MX-68. Arthritis Rheum 2003; 48(1): 240-7.

Elango T, Dayalan H, Gnanaraj P, Malligarjunan H, Subramanian S. Impact of methotrexate on oxidative stress and apoptosis mark- ers in psoriatic patients. Clin Exp Med 2014; 14(4): 431-7.

Salvarani C, Boiardi L, Macchioni P, Pipitone N, Catanoso M, Pigatto P. Multidisciplinary focus on cyclosporin A. J RheumatolSuppl 2009; 83: 52-5.

Balak DM. Fumaric acid esters in the management of psoriasis. Psoriasis (Auckl) 2015; 5: 9-23.

Wong T, Hsu L, Liao W. Phototherapy in psoriasis: a review of mechanisms of action. J Cutan Med Surg 2013; 17(1): 6-12.http://dx.doi.org/10.2310/7750.2012.11124PMID: 23364144

ssM. Bahramizadeh, M. Bahramizadeh, B. Kiafar, A.H. Jafarian, A.R. Nikpoor,

M. Hatamipour, H. Esmaily, Z. Rezaeemehr, S. Golmohammadzadeh, S. A. Moosavian, M.R. Jafari, Development, characterization and evaluation of topical methotrexate-entrapped deformable liposome on imiquimod-induced psoriasis in a mouse model, Int. J. Pharm. 569 (2019), 118623,

Raza K, Singh B, Lohan S, et al. Nano-lipoidal carriers of tretinoin with enhanced percutaneous absorption, photostability, biocompatibility and anti-psoriatic activity. Int J Pharm 2013; 456(1): 65-72.

K.R. Redddy, S.V. Satyanarayana, V.J. Reddy, Development and evaluation of clobetasol–loaded solid lipid nanoparticles for topical treatment of psoriasis, Int. J. Appl. Pharm. (2019) 143–150, .

Pradhan M, Singh D, Singh MR. Development characterization and skin permeating potential of lipid based novel delivery system for topical treatment of psoriasis. Chem Phys Lipids 2015; 186: 9-16.

Kang NW, Kim MH, Sohn SY, et al. Curcumin-loaded lipid- hybridized cellulose nanofiber film ameliorates imiquimod-induced psoriasis-like dermatitis in mice. Biomaterials 2018; 182: 245-58.

V.M. Ghate, A.K. Kodoth, A. Shah, B. Vishalakshi, S.A. Lewis, Colloidal nanostructured lipid carriers of pentoxifylline produced by microwave irradiation ameliorates imiquimod-induced psoriasis in mice, Colloids Surf. B Biointerfaces 181 (2019) 389–399.

V. Prasad, S. Chaurasia, Performance evaluation of non-ionic surfactant based tazarotene encapsulated proniosomal gel for the treatment of psoriasis, Mater. Sci. Eng. C 79 (2017) 168–176.

N.V.S.A.I. Priyanka, P. Neeraja, T. Mangilal, M.R. Kumar, Formulation and

Evaluation of Gel Loaded with Microspheres of Apremilast for TransdermalDelivery System, 2019, p. 12

Rajitha P, Shammika P, Aiswarya S, Gopikrishnan A, Jayakumar R, Sabitha M. Chaulmoogra oil based methotrexate loaded topical nanoemulsion for the treatment of psoriasis. J Drug Deliv Sci Technol 2019; 49: 463-76.

P.K. Tripathi, B. Gorain, H. Choudhury, A. Srivastava, P. Kesharwani, Dendrimer entrapped microsponge gel of dithranol for effective topical treatment, Heliyon 5 (2019).

Bessar H, Venditti I, Benassi L, et al. Functionalized gold nanopar- ticles for topical delivery of methotrexate for the possible treatment of psoriasis. Colloids Surf B Biointerfaces 2016; 141: 141-7.

Marchiori ML, Lubini G, Dalla Nora G, et al. Hydrogel containing dexamethasone-loaded nanocapsules for cutaneous administration: preparation, characterization, and in vitro drug release study. Drug Dev Ind Pharm 2010; 36(8): 962-71.

Chiang HM, Lin YT, Hsiao PL, Su YH, Tsao HT, Wen KC. De- termination of marked components–aloin and aloe-emodin–in Aloe vera before and after hydrolysis. Yao Wu Shi Pin Fen Xi 2012; 20: 646-52.

Kumar VS, Navaratnam V. Neem (Azadirachta indica): prehistory to contemporary medicinal uses to humankind. Asian Pac J Trop Biomed 2013; 3(7): 505-14.

Acosta EH, Pérez JAS, Arjona JA, Visioli F. An olive polyphenol based nutraceutical improves cutaneous manifestations of psoriasis in humans. PharmaNutrition 2016; 4(4): 151-3.

Reddy S, Aggarwal BB. Curcumin is a non-competitive and selec- tive inhibitor of phosphorylase kinase. FEBS Lett 1994; 341(1): 19- 22.

Zhang J, Li X, Wei J, et al. Gallic acid inhibits the expression of keratin 16 and keratin 17 through Nrf2 in psoriasis-like skin dis- ease. Int Immunopharmacol 2018; 65: 84-95.

Raut G, Wairkar S. Management of psoriasis with nutraceuticals: An update. Complement Ther Clin Pract 2018; 31: 25-30.

Devi N, Kumar S, Prasad M, Rao R. Eudragit RS100 based microsponges for dermal delivery of clobetasol propionate in psoriasis management. Journal of drug delivery science and technology. 2020 Feb 1;55:101347

Won R. Method for delivering an active ingredient by controlled time release utilizing a novel delivery Vehicle which can be prepared by a process utilizing the active ingredients as a porogen. U.S. Patent 4690825, 1987.

Embil K, Nacht S. The Microsponge Delivery System (MDS): A topical delivery system with Reduced irritancy incorporating multiple triggering Mechanisms for the release of actives. J Microencapsulate, 1996; 13(5): 575-588.

Yang L, Chu JS, Fix JA. Colon-specific drug Delivery: New approaches and in vitro/in vivo Evaluation. Int J Pharm, 2002; 235(1-2): 1-15.

Babu A, Akhtar MS. Design and characterization of microsponge drug delivery system: A Review. Pharm Adv Res, 2021; 4(1): 1105-1113.

Manda R, Suthakaran R, Abhkishekchawan M, Prasanna Panka, Naresh G. A review: microsponge a novel new drug delivery system. Journal of Scientific Research in Pharmacy 2015; 4(1):1-5.

Badhe KP, Saudagar RB. A review on microsponge a novel drug delivery system. Asian J Pharm Tech 2016; 6(1):51-57.

Pandey P, Jain V and Mahajan SC. A review: microsponge drug delivery system. International Journal of Biopharmaceutics 2013; 4(3):225-230.

Lekurwale PA, Upadhye KP, Thakre AR, Bobde KS. A Therapeutic Applications of Microsponge Drug Delivery System. Volume 10, Issue 10, 90-104.

Rajurkar VG, Tambe AB and Deshmukh VK, Topical Anti Inflammatory Gels of Naproxen Entrapped in Eudragit Based Microsponge Delivery System, J Adv Chem Eng 5(2)(2015).

Naresh Kshirasagar, GoverdhanPuchchakayala, Balamurugan. Comparative Pharmacokinetic Studies of Marketed and Microsponges Gel Loaded with Diclofenac Diethylamine in Rabbits, RJPT (2021); 14(12):6385.

Rivastava R, Pathak K (2015) Microsponges: a futuristic approach for oral drug delivery. Expert Opin Drug Deliv 9(7):863–878. https://doi.org/10. 1517/17425247.2012.693072.

Amrutiya N, Bajaj A, Madan M, Development of MDS for topical delivery of mupirocin. AAPS Pharm SciTech 2009;10(2):402–409. https://doi. org/10.1208/s12249-009-9220-

Mahajan Aniruddha G,Jagtap Leena S, Chaudhari Atul L, Swami Sima P,Mali Prabha R, Formulation and evaluation of microsponge drug delivery system using Indomethacin, IRJP 2(10):(2011).

Anjali Sharma, Ranjit Singh, Kumar Guarve, Microsponges Loaded Topical Drug Delivery System for the Effective Management of Rheumatoid Arthritis, Asian Pac. J. Health Sci., (2021); 2349-0659 p- ISSN; 2350-0964.

Liu, Y., Li, L., Ma, X., Wei, W., Li, H., Wang, Y., & Zhu, S. (2017). Curcumin-loaded microspheres protect against glutamate-induced oxidative stress and apoptosis in PC12 cells. Journal of Microencapsulation, 2017; 34(5):486-494.

Kumari A, Jain A, Hurkat P, Tiwari A, Jain SK, Eudragit S100 coated MDS for Colon targeting of prednisolone. Drug Dev Ind Pharm 2018; 44(6):902-913.

Garg, T., Singh, O., Arora, S., & Murthy, R. S. Microsponges: A futuristic approach for oral drug delivery. Expert Opinion on Drug Delivery, 2012; 9(8):863-878.

Sharma, P. K., Sharma, G. D., & Sharma, A. K. Microsponge drug delivery system: A review. International Journal of Drug Development and Research, 2011; 3(1)144-163.

Pichot, C., & Zerroukhi, S.. Polyacrylamide-based microsponges as drug delivery systems. International Journal of Pharmaceutics, 2013; 443(1-2), 220-227.

Sathali, A. A., Hasan, M., & Ramadan, W. S. Formulation, optimization, and evaluation of eudragit-based microsponges for topical delivery of fluocinolone acetonide. AAPS PharmSciTech, 2017; 18(7): 2649-2660.

Kadam, V., & Dhoble, S. Preparation and evaluation of eudragit based microsponges for topical delivery of clotrimazole. Asian Journal of Pharmaceutical Sciences, 2017; 12(5):445452.

Shaikh, K., & Kale, S. Design, development, and characterization of eudragit-based microsponges of aceclofenac for topical delivery. Drug Development and Industrial Pharmacy, 2016; 42(4):630-641.

Bhadoriya, S. S., Ganeshpurkar, A., Narwaria, J., & Rai, G. (2016). Eudragit-based microsponges of glipizide: formulation, optimization, and in vitro evaluation. Journal of Drug Delivery Science and Technology, 2016; 34:80-88.

Patel, D. B., Patel, C. N., Thakkar, V. T., & Shelat, P. K. Development and characterization of eudragit-based microsponges of aceclofenac. AAPS PharmSciTech, 2015; 16(3):623-631.

Lalitha KS, Shankar M, Likhitha D, Dastagiri J, Niranjan BM. A current view on microsponge. Drug Delivery System European Journal of Molecular Biology And Biochemistry 2016; 3(1):33-38.

Gandhi S, Dol H, Ghorpade S. Microsponge: a prominent strategy to accelerate performance of topical formulation. International Journal of Pharmacy and Pharmaceutical Research 2016; 7(3).

Rajurkar VG, Tambe AB and Deshmukh VK. Topical anti-inflammatory gels of Naproxen entrapped in eudragit based microsponge delivery system. Journal of Advanced Chemical Engineering 2015; 5(2).

Rajab NA, Jawad MS. Formulation and in vitro evaluation of Piroxicam microsponge as a tablet. International Journal of Pharmacy And Pharmaceutical Sciences 2016; 8(2).

Jain N, Sharma PK, Banik A. Recent advances on microsponge delivery. International journal of Pharmaceutical Sciences Review and Research 2011:8(2).

Kaur J, Kaur J, Jaiswal S, Gupta GD. Recent advances in topical drug delivery system. Indo American P’ceutical Rese 2016; 6(7): 2231-6876.

Arathy SA, Sunil S. Microsponges-A New Hope for Drug Delivery System. Journal of Pharmaceutical Sciences and Research. 2020 Jul 1; 12(7):970-2.

Bae SE, Son JS, Park K, et al. Fabrication of covered porous PLGA microspheres using hydrogen peroxide for controlled drug delivery and regenerative medicine. J Control Release 2009; 133:37-43.

Liu LS, Liu SQ, Ng SY, et al. Controlled release of interleukin-2 for tumor immunotherapy using alginate/chitosan porous microspheres. J Control Release 1997; 43:65-74.

Lopez GP, Buranda T, Gopala Raju VRR, et al. biologically functionalized porous microspheres. US2004005352; 2004.

Natarajan, J.V., et al. "Multiple emulsions: A versatile platform for targeted drug delivery." International Journal of Pharmaceutics, vol. 602, 2021, 120645.

Aloorkar, N. H., Kulkarni, A. S., Ingale, D. J., & Patil, R. A. Microsponges as innovative drug delivery systems. Int J Pharm Sci Nanotechnol, 2012; 5(1);1597-1606.

Amrutiya N, Bajaj A, Madan M. AAPS Pharm. Sci. Tech 2009:10(2); 402-09.

Grimes P.E. A microsponge formulation of hydroquinone 4% and Retinol 0.15% in the treatment of melasma and post-inflammatory Hyperpigmentation 2004; 74(6):362-8.

Comoglu T., Savaşer A., Ozkan Y., Gönül N., Baykara T. Enhancement of Ketoprofen bioavailability by formation of microsponge tablets. Pharmacies. 2007; 62(1):51-4.

Jayaweera D.M. Medicinal Plants (Indigenous and Exotic) used in Ceylon. Part-II. A Publication of the Natural Sciences Council of Sri Lanka: Colombo .1980.

Pushpa, Kumari, Shashi Kiran Mishra. A comprehensive review on novel microsponges drug delivery approach. Asian, J. Pharm. Cli. Res. 2016; (9):25-30.

Sha-Sha Li, Guo-Feng Li, Li Liu, Xia’s Jiang, Bin Zhang, Zhi-Gang Liu et al. Evaluation of paeonol skin target Delivery from its microsponge formulation: In vitro Skin Permeation and In vivo Micro dialysis, Polson. 2013; 8(11):789-98.

Richard Won, Palo Alto, Calif., United States Patent 5145675A.

Rashmi Sareen, Kavita Nath, Nitin Jain, and K. L. Dhar, Curcumin Loaded Microsponges for Colon Targeting in Inflammatory Bowel Disease: Fabrication, Optimization, and In Vitro and Pharmacodynamic Evaluation. Hindawi Publishing Corporation, BioMed Research International (2014) Article ID 340701, 7 pages

Amrita Kumari, Ankit Jain, Pooja Hurkat, Ankita Tiwari & Sanjay K. Jain, Eudragit S100 Coated Microsponges for Colon Targeting of Prednisolone, (2017) https://doi.org/10.1080/03639045.2017.1420079.

S.L. Cantor, M.A. Khan, A. Gupta, Development and optimization of taste masked orally disintegrating tablets (ODTs) of clindamycin hydrochloride, Drug Dev. Ind. Pharm. 41 (2015) 1156e1164.

Farhana Sultan and Himanshu Chopra, formulation and evaluation of Luliconazole Microsponges loaded Gel for topical delivery (2021) Research journal of pharmacy and technology 5775-5780.

P. Li, Z. Yang, Y. Wang, et al., Microencapsulation of coupled folate and chitosan nanoparticles for targeted delivery of combination drugs to colon, J. Microencapsul. 32 (2014) 40-45.

Jyoti and Kumar S: Innovative and novel strategy: Microsponge for topical drug delivery. Journal of Drug Delivery and Therapeutics 2018; 8(5): 28-34.

Jain P. Formulation and evaluation of colon specific tablet containing microsponges of metoprolol succinate. Int J Pharm Life Sci 2015; 6:4851-6.

Sneha S. Kardile, Raosaheb S. Shendge, Colon-specific tablets containing naproxen microsponges for effective treatment of inflammatory bowel disease, International Journal of Health Sciences, 6(S3), 8419-8441.

Hans Mansi*1, Dua Jagdeep Singh 1, Prasad D.N 2, Monika1, Sharma Diksha, formulation and Evaluation of Fluconazole Microsponge using Eudragit L 100 by Quasi Emulsion Solvent Diffusion Method, Journal of Drug Delivery & Therapeutics. 2019; 9(3-s):366-373.

Joshna Booravilli,Janaki Devi Sirisolla,Shivani Saluru, Formulation and Evaluation of Ketoconazole Microsponge Topical Gel, Journal of Drug Delivery & Therapeutics. 2019; 9(3s):366-373.

Published

2025-06-15

How to Cite

Kokate S.Tanvi, Dr. Vikrant P. Wankhade, Dr. Shrikant D. Pande, Dr. Sandeep C. Atram, Dr. Nishan N. Bobade, VikramV.Bhoyar, & Neha S. Ghogare. (2025). Emerging Role of Microsponges in the Treatment of Psoriasis: A Comprehensive Review. Asian Journal of Pharmaceutical Research and Development, 13(3), 68–77. https://doi.org/10.22270/ajprd.v13i3.1559

Most read articles by the same author(s)