Formulation and Evaluation of Phytosome for the Topical Drug Delivery
DOI:
https://doi.org/10.22270/ajprd.v13i4.1584Abstract
The aim of the present study was formulation and evaluation of phytosome for the topical drug delivery. Quercetin loaded phytosome were prepared by ether injection method. The prepared phytosome were further characterized for particle size, zeta potential, entrapment efficiency, drug content and in-vitro diffusion study.On the basis of criteria (the drug diffused at 4 Hr. not more than 20%, not less than 15%) the F2 batch is optimized and the optimized batch is incorporated in gel for further evaluation such as pH determination, drug content, viscosity and in-vitro diffusion study. From the in-vitro diffusion study we observed that the quercetin release from phytosomal gel by zero order kinetics which show controlled release of quercetin from phytosomal gel.
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Baibhav J, Gurpreet S, Rana AC, Seema S, Vikas S. Emulgel: a comprehensive review on the recent advances in topical drug delivery. International Research journal of pharmacy. 2011;2(11):66-70.
Vollono L, Falconi M, Gaziano R, Iacovelli F, Dika E, Terracciano C, Bianchi L, Campione E. Potential of curcumin in skin disorders. Nutrients. 2019 Sep 10;11(9):2169.
Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Frontiers in pharmacology. 2014 Jan 10;4:177.
Patil S, Mhaiskar A, Mundhada D. A review on novel drug delivery system: a recent trend. International Journal of Current Pharmaceutical & Clinical Research. 2016;6(2):89-93.
Semalty A, Semalty M, Rawat MS, Franceschi F. Supramolecular phospholipids–polyphenolics interactions: The Phytosome strategy to improve the bioavailability of phytochemicals. Fitoterapia. 2010 Jul 1;81(5):306-14.
Gandhi A, Dutta A, Pal A, Bakshi P. Recent trends of phytosomes for delivering herbal extract with improved bioavailability. J. Pharmacogn. Phytochem. 2012 Nov 1;1(4):6-14.
Mbah CC, Builders PF, Attama AA. Nanovesicular carriers as alternative drug delivery systems: ethosomes in focus. Expert opinion on drug delivery. 2014 Jan 1;11(1):45-59.
Dongare PN, Motule AS, Dubey MR, More MP, Patinge PA, Bakal RL, Manwar JV. Recent development in novel drug delivery systems for delivery of herbal drugs: An updates. GSC Advanced Research and Reviews. 2021;8(2):008-18.
Barani M, Sangiovanni E, Angarano M, Rajizadeh MA, Mehrabani M, Piazza S, Gangadharappa HV, Pardakhty A, Mehrbani M, Dell’Agli M, Nematollahi MH. Phytosomes as innovative delivery systems for phytochemicals: A comprehensive review of literature. International journal of nanomedicine. 2021 Oct 15:6983-7022.
Asijia R, Sharma D, Nirmal H. Development of proniosomes gel as a drug carrier for transdermal delivery of acyclovir. Journal of Drug Discovery and Therapeutics. 2014;2(18):41-51.
Shakeri A, Sahebkar A. Opinion paper: phytosome: a fatty solution for efficient formulation of phytopharmaceuticals. Recent patents on drug delivery & formulation. 2016 Apr 1;10(1):7-10.
Kumar A, Kumar B, Singh SK, Kaur B, Singh S. A review on phytosomes: Novel approach for herbal phytochemicals. Asian J Pharm Clin Res. 2017 Oct 1;10(10):41-7.
KS S, Aditi K. Phytosome as a Novel Drug Delivery System for Bioavailability Enhancement of Phytoconstituents and its Applications: A Review. Journal of Drug Delivery & Therapeutics. 2021 May 1;11(3).
Rachakonda TD, Schupp CW, Armstrong AW. Psoriasis prevalence among adults in the United States. Journal of the American Academy of Dermatology. 2014 Mar 1;70(3):512-6.
Pradniwat P, Chanprasert S. Properties, pharmacological activities and toxicities of quercetin. Thai Journal of Toxicology. 2022 Aug 22;37(2):1-9.
Chaubey P, Patel RR, Mishra B. Development and optimization of curcumin-loaded mannosylated chitosan nanoparticles using response surface methodology in the treatment of visceral leishmaniasis. Expert Opinion on Drug Delivery. 2014 Aug 1;11(8):1163-81.
Kapse MV, Mulla JA. Unlocking the potential of phytosomes: a review of formulation techniques, evaluation methods, and emerging applications. Acta Materia Medica. 2024 Dec 28;3(4):509-20.
Roy D, Nagori M, Jain V, Pal P. Development, Characterization and Evaluation of Phytosomal Gel of Curcumin for the Treatment of Topical Fungal Infection. International Journal of Newgen Research in Pharmacy & Healthcare. 2023 Jun 30:62-9.
Karpuz M, Gunay MS, Ozer AY. Liposomes and phytosomes for phytoconstituents. InAdvances and avenues in the development of novel carriers for bioactives and biological agents 2020 Jan 1 (pp. 525-553). Academic Press.
Fatima Z, Shahidulla SM. Formulation, optimization and evaluation of hexadecanoic acid phytosomal gel for anti-fungal activity. International Journal of Pharmaceutical Sciences and Research. 2023;14(1):519-29.
Das MK, Kalita B. Design and evaluation of phyto-phospholipid complexes (phytosomes) of rutin for transdermal application. Journal of applied pharmaceutical science. 2014 Oct 30;4(10):051-7.
Gaur PK, Mishra S, Aeri V. Formulation and evaluation of guggul lipid nanovesicles for transdermal delivery of aceclofenac. The Scientific World Journal. 2014;2014(1):534210.
Joshua JM, Anilkumar A, Cu VE, T Vasudevan DE, Surendran SA. Formulation and evaluation of antiaging phytosomal gel. Asian J Pharm Clin Res. 2018 Mar;11(3):409-22.
Mannan A, Begum S, Rasheed A. Formulation, Development and Evaluation of Phytosomal Gel of Thymoquinone.
Vasanth S, Dubey A, GS R, Lewis SA, Ghate VM, El-Zahaby SA, Hebbar S. Development and investigation of vitamin C-enriched adapalene-loaded transfersome gel: a collegial approach for the treatment of acne vulgaris. AAPS PharmSciTech. 2020 Feb;21:1-7.
Singh R, Rathi JC, Sharma R. Formulation and evaluation of phytosomal gel of resveratrol. International Journal of Drug Discovery and Herbal Research. 2022;12(1):11-8.
Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm. 2010 May 1;67(3):217-23.
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