Hepatoprotector Effect of Corn Silk Ethanol Extract (Stigma maydis) on Paracetamol-Induced White Male Rats
DOI:
https://doi.org/10.22270/ajprd.v9i5.1008Keywords:
Corn Silk Ethanol Extract, Hepatoprotector, ParacetamolAbstract
Objectives: Corn silk (Stigma maydis) is one part of the corn plant that contains useful chemical compounds, including flavonoid compounds. The ability of flavonoid compounds to capture free radicals that cause liver damage. The purpose of this study was to determine the hepatoprotective effect of corn silk ethanol extract on male white rats induced by paracetamol and to determine the effect of varying doses of corn silk ethanol extract as a hepatoprotector.
Data Sources Study Selection: This study is an experimental study testing the hepatoprotective effect of corn silk ethanol extract using male white rats
Summary of contents of the article:This study using 20 male white rats which were divided into 5 groups, namely negative control given NaCMC, positive control induced by toxic dose of paracetamol, and group of corn silk ethanol extract doses of 250, 500, 1000 mg/kgBW. The measurement parameters were the levels of SGOT and SGPT enzymes, the ratio of liver weight, and histopathological examination of the liver. The data obtained were analyzed descriptively, statistically with two-way and one-way ANOVA followed by Duncan's test and. The results showed that administration of corn silk ethanol extract could reduce levels of SGOT and SGPT enzymes, and analysis using two-way ANOVA showed that there was a significant difference in levels of SGOT and SGPT in the test group with (p<0.05). The ratio of liver weight was analyzed by one-way ANOVA. The results showed that there was no significant difference to the ratio of organ weight in the test group with (p>0.05). Histopathological picture showed improvement of liver parenchymal morphology on administration of corn silk ethanol extract.
Conclusion: Based on the results of the study, it was concluded that the presence of a hepatoprotector effect on the ethanol extract of corn silk and that there was an influence of the dose variation on the hepatoprotector effect with a dose of 1000 mg/kgBW was more effective as a hepatoprotector.
Downloads
References
2. Poli, G. &Parola, M. 1997. Oxidative Damage and Fibrogenesis. Free Radic Biol Med. 22: 287-305.Ramadani AP, Tamhid HA, Sadrina TL, Jasno, Mustafidah M. 2020. HepatoprotectiveEffectofCornSilkInfusion in Male WistarRats. Jurnal ofSciencesand Data Analysis.2020; 1(1) 51-55.
3. World Health Organization (WHO). 2011. World hepatitis day [linked periodically]. http://www.who.int/csr/disease/hepatitis/world_hepatitis_day/en/ [7 February 2012].
4. Indonesian Ministry of Health. 2010. Bulletin of Health Data and Information Window. Ministry of Health of the Republic of Indonesia. Jakarta. 2010; 2(2);1-20.2.
5. Podolsky, D.K. &Isselbacher, K.J. 2002. Diagnostic Tests in Liver Disease. In: Harisson Principles of Internal Medicine. 13th Edition. EGC Medical Book Publisher. Jakarta.
6. Yusuf RP. 2009. Study of Farmers' Income in Corn Farming Business (Case in Sanggalangit Village, Gerokgak District, Buleleng Regency). SOCA Journal of Socio-Economic Agriculture and Agribusiness, 2009; 9(3):263–390.
7. Liu J, Songyi L, Zuozhao W, Cuina W, Erlei Wang, Yang Z. Supercriticalfluid extraction of flavonoids from maydis stigma and its nitrite-scavenging ability.Food and Bioproducts Processing; 2011; 89(4):333–9.
8. Hasanudin, K., Hashim, P. and Mustafa, S. Corn Silk (Stigma Maydis) in Healthcare: A Phytochemical and Pharmacological Review. Molecules. 2012; 17. 9697-9715.
9. Anonymous. 1995. Materia Medika Indonesia (Volume VI). Jakarta: Ministry of Health of the Republic of Indonesia.
10. Guo, J., Liu, T., Han, L. & Liu, Y. The Effects of Corn Silk on Glycaemic Metabolism. Nutrition & Metabolism.20069; 6:47.
11. Zhang Y, Sui DY, Zhou JS. & Zhou HL. 2011. Microwave-assisted Extraction and Antihyperlipidemic Effect of Total Flavonoids From Corn Silk. African Journal of Biotechnology. 2011; 10(65), pp. 14583-14586.
12. Shamkhy, A., Al-Chalabi, R., Al-Amery, H. Effect of Corn Silk Extract on Kidney Stone Decomposition in Comparison with Alkalinizer agent (uralyte). Int J Health Nutr.2012; 3(2): 1- 5.
13. Bhaigyabati T, Ramya J, Usha K. Effect of Methanolic Extract of Sweet Corn Silk on Experimentally Induced Hyperthyroidsm in Swiss Albino Rats. IRJP. 2012; 3(3).
14. Nessa, F., Ismail, Z., Mohamed, N. 2012. Antimicrobial Activities of Extracts and Flavonoid Glycosides of Corn Silk (Zea mays L). International Journal of Biotechnology for Wellness Industries.2012;1:115-121.
15. Ebrahimzadeh MA, Pourmorad F, Hafezi S. Antioxidant activity of Iranian corn silk. Turk J variety. 2008; 32:43-9.
16. Sarepoua E, Tangwongchai R, Suriharn B, Lertrat K. Relationships Between Phytochemicals and Antioxidant in Corn Silk. International Food Research Journal. 2013; 20(5):2073-2079.
17. Ramadani AP, Tamhid HA, Sadrina TL, Jasno, Mustafidah M. 2020. HepatoprotectiveEffectofCornSilkInfusion in Male WistarRats. Jurnal ofSciencesand Data Analysis.2020; 1(1):51-55.
18. Karami M, S. Saeidnia, and A. Nosrati. 2013. Study of Hepatoprotective Activity of Feijoa sellowiana Fruit Methanol Extract Against MDMA Using Isolated Rat Liver Perfusion System. Iran J Pharm Res.;2013; 12(1)85-91.
19. Indonesian Ministry of Health. 1979. Indonesian Pharmacopoeia (Third Edition). Indonesian Ministry of Health. Jakarta.
20. Hastuti, T. 2008. Transaminase Enzyme Activity and Histopathological Overview of Mice Liver Given Kopyor Coconut After Paracetamol Induction.
21. Wilmana PF, Gunawan SG. 2007. Analgesics, Non-Steroid Anti-Inflammatory and Other Joint Disorder Drugs. Jakarta. FKUI Publishing Center.
22. Bandy. 2009. Evaluation of the Use of Intravenous Paracetamol in Inpatient Childhood Patients at Mas Amsyar Hospital Kasongan, Central Kalimantan. Drug Use Evaluation.; 2009; 1(2):422-426.
23. Wikanta T, Prehati R, Rahayu L, Fajarningsih ND. 2010. Effect of Turbinariadecurrens Ethanol Extract on Repair of Liver Damage in White Rats. Journal of Postharvest and Marine and Fisheries Biotechnology.: 2010; 5(1):19-28.
24. Winarsi, H., 2007, Natural Antioxidants and Free Radicals, Kanisius, Yogyakarta, pp.2007; 12(15):18:79-81.
25. Amic D, Davidovic D, Beslo D, Trinajstic N. 2003. Structure-Radical Scavenging Activity Relationships of Flavonoids. Croatia Chemica Acta, 2003; 76(1):55-61.
26. Nzaramba. (2008). Ischaemic preconditioning modulates the activity of Kupffer cells during in vivo reperfusion injury of rat liver. Cell Biochem Funct 2003; 21(4):299–305.
Published
How to Cite
Issue
Section
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).