An Overview on Microemulsion as a Topical Drug Delivry System
DOI:
https://doi.org/10.22270/ajprd.v11i3.1275Keywords:
TDDS, Microemulsions, thermodynamically stable, amphiphile, solubilizationAbstract
Due to their extended shelf life, enhanced drug solubilization, and simplicity in preparation and administration, microemulsions are among the greatest possibilities for new drug delivery systems. Microemulsions are liquid mixtures of amphiphile, water, and oil that are thermodynamically stable and optically isotropic. They have become cutting-edge drug delivery systems that enable controlled or sustained release for parenteral, ophthalmic, percutaneous, topical, and transdermal medication administration.Because of their low viscosity, transparency, and, more precisely, their thermodynamic stability, microemulsions may be easily distinguished from regular emulsions. Microemulsions have a wide range of uses and applications, including in the pharmaceutical, agrochemical, cutting oil, biotechnology, food, and cosmetic industries as well as in analytical applications and environmental detoxification. This review paper's main goal is to talk about using microemulsions as a medicine delivery mechanism with other potential uses.
Downloads
References
2. Vyas SP and Khar RK. Targetted and Controlled Drug Delivery Novel Carrier System 1st ed., CBS Publishers and Distributors, New Delhi, 2002:411-447.
3. Hadgraft J, Guy R. In; Transdermal Drug Delivery, Marcel Dekker, Inc., New York and Basel,35,296.
4. Prausnitz MR, Mitragotri S, Langer R. Current Status and Futyre Potential of Transdermal Drug Delivery. Nature Reviews, Drug Discovery, 2004; (3):115-124.
5. Hoar TP, Schulman JH, Transparent Water- In-Oil Dispersions, The Oleopathic Hydro-Micelle, Nature, 1943: 152; 102-103.
6. Schulman, J.H, Stoeckenius, W Prince, L.M, Mechanism Of Formation and Structure Of Microemulsions By Electron Microscopy, J. Phys. Chem, 1959: 63,1677-1680.
7. Vyas SP, Khar RK. Submicron Emulsions in Targeted and Controlled Drug Delivery, Novel Carrier System; Cbs Publishers and Distributors, New Delhi, 2002:(282-302).
8. Jadhav KR. et al., Applications Of Microemulsion Based Drug Delivery System. Curr Drug Deliv, 2006; 3(3):267-73.
9. Cordero J, Alarcon L, Escribano E, Obach R, Domenech J. A Comparative Study Of The Transdermal Penetration Of A Series Of Nonsteroidal AntiInflammatory Drugs, J. Pharm. Sci, 1997, 86:503–508.
10. Prince L M, Microemulsions. In: Lissant KJ (Ed), Emulsions And Emulsion Technology,New York : Marcel Dekker; 1974: 125-178.
11. Delgado-Charro MB, Iglesias-Vilas G, Blanco-Mendez J, Lopez QM, Marty Jp, Guy RH. Delivery Of A Hydrophilic Solute Through The Skin From Novel Microemulsion Systems. Eur J Pharm Biopharm 1997; 43: 37-42.
12. Celebi N, Kıslal O, Tarımcı N. The Effect of Β- Cyclodextrin And Penetration Additives On The Release Of Naproxen From Ointment Bases. Pharmazie 1993; 48: 914-9179, Gasco M R, Gallarate M, Trotta M, Bauchiero L, Gremmo E, Chiappero O, J. Pharm. Biomed,1989; 7: 433.
13. Holmberg, K., Handbook of Applied Surface and Colloid Chemistry. 2002: Chichester, New York, Wiley.
14. Giustini MS, Murgia G, Palazzo. Does The Schulman's Titration Of Microemulsions Really Provide Meaningful Parameters? Langmuir, 2004; 20(18):7381-4
15. 15.Emsap. W.J. et al. Disperse Systems in Modern Pharmaceutics. Fourth Edition. Ed: Banker. G.S. Rhodes, C.T. Marcel Dekker Inc. New York. 2002; p260.
16. Sarkhejiya Naimish A et al. Emerging Trend of Microemulsion in Formulation and Research. International Bulletin of Drug Research. 2000; 1 (1): 54-83.
17. Kunieda H. et al. The Journal of Physical Chemistry 1988; 92: 185.
18. Park K M and Kim C K. Preparation and evaluation of flurbiprofen loaded Microemulsions for parental delivery. International Journal of Pharmaceutics 1999; 181: 173-179.
19. Peira E. and Transdermal permeation of apomorphine through hairless mouse skin from microemulsions. International Journal of Pharmaceutics 2001; 226: 47-51.
20. Rhee Y S. et al. Transdermal delivery of ketoprofen using Microemulsions. International Journal of Pharmaceutics 2001; 226: 161-170.
21. Ashok Patel and Pradeepvavia R. Preparation and In-vivo Evaluation of Self-Microemulsifying Drug Delivery System Containing fenofibrate. The AAPS Journal 2007; 226: 344-352.
22. Peltola S. et al. Microemulsions for topical delivery of estradiol. International Journal of Pharmaceutics 2003; 254: 99-107.
23. Constantinides PP. et al. Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions incorporating medium-chain glycerides. Pharmaceutical Research 1994; 11: 13 85–90.
24. Constantinides PP. et al. Water-in-oil microemulsions containing medium-chain fatty acids/salts: formulation and intestinal absorption enhancement evaluation. Pharmaceutical Research 1996; 13(2): 205–105.
25. Jadhav. K.R. et al. Design and Evaluation of Microemulsion Based Drug Delivery System. International Journal of Advances in Pharmaceutical Sciences. 2010; 1: 156-166.
26. Brime B. et al. Amphotericin B in oil-water lecithin-based microemulsions: formulation and toxicity evaluation. Journal Pharmaceutical Sciences 2002; 91(4): 1178–85.
27. Thakker K D. and Chern W H. Development and Validation of In Vitro Release Tests for Semisolid Dosage Forms - Case Study. Dissolution Technologies 2003; 15: 10-15.
28. Shaikh I M. et al. Topical delivery of aceclofenac from lecithin organogels: preformulation study. Current Drug Delivery 2006; 3(4): 1727.
29. Tomsic M. et al. Water–Tween 40®/Imwitor 308®–isopropyl myristate microemulsions as delivery systems for ketoprofen: Smallangle Xray scattering study. International Journal of Pharmaceutics 2006; 327: 170– 177.
30. Martin A. Coarse Dispersions In: Physical Pharmacy. Fourth Edition. B.I. Waverly Pvt. Ltd. New Delhi. 1994; p495
31. 31.Giustini M. et al. Microstructure and dynamics of the water-in-oil CTAB/n-pentanol/nhexane/water microemulsion: spectroscopic and conductivity study. Journal Physical Chemistry1996; 100: 3190 3198.
32. Hsiu-O Ho. et al. Preparation of microemulsions using polyglycerol fatty acid esters as surfactant for the delivery of protein drugs. Journal of Pharmaceutical Sciences 1996; 85: 138-143.
33. Corswant C. et al. Triglyceride –based microemulsion for intravenous administration of sparingly soluble substances. Journal of Pharmaceutical Sciences 1998; 87: 200-208.
34. Dreher F. et. al. Interaction of a lecithin microemulsion gel with human stratum corneumand its effect on transdermal transport. Journal of Controlled Release 1997; 45:131 140.
35. Lv FF. et al. Studies on the stability of the chloramphenicol in the microemulsion free of alcohols. European Journal of Pharmaceutics and Biopharmaeutics 2006; 62: 288-294.
Published
How to Cite
Issue
Section
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.