A Review on Microspheres: Preparation, Characterization and Applications
DOI:
https://doi.org/10.22270/ajprd.v10i6.1204Keywords:
Microsphere, Types of microspheres, evaluation, applicationAbstract
Small sphere-shaped particles are known as microspheres and their particle size range is 1micrometer to 1000 micrometer. They are free-moving, spherical particles that can be manufactured from proteins or artificial polymers. There are several methods for delivering a medicinal chemical to the target region with a regulated, prolonged release. which naturally decomposes.Microcapsules and micromatricesare two of the different types of microspheres. There are numerous varieties of microspheres that are described. Microspheres are one of the most popular varieties and provide a number of benefits.Theseprepared microspheres can be compressed or filled with a firm gelatin. There are several methods for creating microspheres, including single-emulsion, double-emulsion, solvent evaporation, phase separation coacervation, and spray drying. Microspheres are assessed using a variety of assessment methods, and they are examined in relation to a number of applications, including the delivery of vaccines, chemotherapy, ophthalmic drugs, gene therapies, and oral, nasal, and buccal drug delivery of pharmaceuticals.
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References
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37. Prasanth VV, Moy AC, Mathew ST, Mathapan R. Microspheres-an overview. International journal of research in pharmaceutical and biomedical sciences. 2011 Apr; 2(2):332-8.
38. Mohan ME, Sujitha HA, Rao VU, Ashok M, Kumar AB. A brief review on mucoadhesive microspheres. IJRRPAS. 2014; 4(1):975-86.
39. Kumar AM, Rao KP. Poly (palmitoyl-L-hydroxyproline ester) microspheres as potential oral controlled drug delivery system. International journal of pharmaceutics. 1997 Apr 14; 149(1):107-14.
40. Shaji J, Poddar A, Iyer S. Brain-targeted nasal clonazepam microspheres. Indian Journal of pharmaceutical Sciences. 2009 Nov; 71(6):715.
41. Chowdary KP, Babu JS. Permeability of ethylene vinyl acetate copolymer microcapsules: Effect of solvents. Indian journal of pharmaceutical sciences. 2003; 65(1):62.
42. Gupta R, Shanthi C, Mahato AG. Characterization of Captopril-Ethyl Cellulose Microspheres by Thermal Analysis. Int. J. Drug Dev. Res. 2010; 2:394-8.
43. Chowdary KP, Babu JS. Permeability of ethylene vinyl acetate copolymer microcapsules: Effect of solvents. Indian journal of pharmaceutical sciences. 2003; 65(1):62.
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48. Virmani T, Gupta J. Pharmaceutical application of microspheres: an approach for the treatment of various diseases. Int J Pharm Sci Res. 2017; 8(8):3253-60.
49. Karki R, Jha SK, GS SK, Goli D. Formulation and evaluation of microspheres containing fluvastatin sodium. International Journal of Drug Development and Research. 2012; 4(2):0-.
50. Sailaja AK, Begum N. Formulation and evaluation of cox-2 inhibitor (etoricoxib) loaded ethyl cellulose nanoparticles for topical drug delivery. Nano Biomedicine and Engineering. 2018; 10(1):1-9.
51. Singh C, Purohit S, Singh M, Pandey BL. Design and evaluation of microspheres: A Review. Jddr. 2013; 2(2):18-27.
52. Kreuter J, Nefzger M, Liehl E, CzokR, Voges R. Microspheres – A Novel Approach in Drug Delivery System. J Pharm sci. 1983; 72: 1146
53. Costa P, Lobo JM. Modeling and comparison of dissolution profiles. European journal of pharmaceutical sciences. 2001 May 1; 13(2):123-33.
54. Jain NK, editor. Progress in controlled and novel drug delivery systems. CBS Publishers & Distributors; 2004.
55. Jadhav N, Patel V, Mungekar S, Bhamare G, Karpe M, Kadams V. Microsponge delivery system: an updated review, current status and future prospects. Journal of Scientific and Innovative Research. 2013 Sep 21;2(6):1097-110.
56. Mahapatra Bk, Kumar Shah S, Mohanto S, Mantry S. Preparation Design and In-Vitro Evaluation of Sustained Release Microsphere of Ropinirole Hydrochloride By Emulsion Solvent Evaporation Technique. International Journal of Innovative Pharmaceutical Sciences and Research. 2019 May 27; 7(5):48-60.
57. Rajput S, Agrawal P, Pathak A, Shrivasatava N, Baghel SS, Baghel RS. A review on microspheres: Methods of preparation and evaluation. World journal of pharmacy and pharmaceutical sciences. 2012; 1:422-38.
58. Meghna KS, Pillai K, Giridas S, Sreelakshmi C, Vijayakumar B. Microsphere a drug delivery system–a review. International Journal of Novel Trends in Pharmaceutical Sciences. 2017 Aug 31; 7(4):109-18.
59. Kumar, A., Mahajan, S., & Bhandari, N. Microspheres: a review. World J Pharm Pharm Sci, 2017; 14(6), 724-40.
60. Nikam VK, Gudsoorkar VR, Hiremath SN, Dolas RT, Kashid VA. Microspheres-A Novel drug delivery system: An overview. International journal of pharmaceutical and chemical sciences. 2012 Jan;1(1).
61. Goud CM, Sravan M, Vinod M, Ramana H, Venkateshwarlu G. Invitro Wassh off Comparision Studies of Sodium Alginate Mucoadhesive Microspheres Using Different Polymers.
62. Hafeli U. Physics and Chemistry Basic of Biotechnology. Focus on biotechnology. Review. Radioactive Microspheres for Medical Application. 2002; 7:213-48.
63. Khan MS, Doharey V. A review on nasal microsphere. International Journal of Pharma Sciences. 2014; 4:496-506.
2. Thanoo BC, Sunny MC, Jayakrishnan A. Cross-linked chitosan microspheres: preparation and evaluation as a matrix for the controlled release of pharmaceuticals. Journal of pharmacy and pharmacology. 1992 Apr; 44(4):283-6.
3. Sahil K, Akanksha M, Premjeet S, Bilandi A, Kapoor B. Microsphere: A review. Int. J. Res. Pharm. Chem. 2011;1(4):1184-98.
4. Virmani T, Gupta J. Pharmaceutical application of microspheres: an approach for the treatment of various diseases. Int J Pharm Sci Res. 2017; 8(8):3253-60.
5. Li SP, Kowarski CR, Feld KM, Grim WM. Recent advances in microencapsulation technology and equipment. Drug Development and Industrial Pharmacy. 1988 Jan 1; 14(2-3):353-76.
6. Kreuter J, Nefzger M, Liehl E, CzokR VR. Microspheres–A Novel Approach in Drug Delivery System. J Pharm sci. 1983; 72:1146.
7. Margel S, Wiesel E. Acrolein polymerization: monodisperse, homo, and hybrido microspheres, synthesis, mechanism, and reactions. Journal of Polymer Science: Polymer Chemistry Edition. 1984 Jan; 22(1):145-58.
8. Wakiyama N, Juni K, Nakano M. Preparation and evaluation in vitro of polylactic acid microspheres containing local anesthetics. Chemical and Pharmaceutical Bulletin. 1981 Nov 25; 29(11):3363-8.
9. Patel NR, Patel DA, Bharadia PD, Pandya V, Modi D. Microsphere as a novel drug delivery. International Journal of Pharmacy & Life Sciences. 2011 Aug 1; 2(8).
10. Toshio Y, Mitsuru H, Shozo M, Hitoshi S. Specific delivery of mitomycin c to the liver, spleen and lung: Nano-and m1crospherical carriers of gelatin. International Journal of Pharmaceutics. 1981 Apr 1;8(2):131-41.
11. Patel NR, Patel DA, Bharadia PD, Pandya V, Modi D. Microsphere as a novel drug delivery. International Journal of Pharmacy & Life Sciences. 2011 Aug 1;2(8).
12. Herfarth H, Obermeier F, Andus T, Rogler G, Nikolaus S, Kuehbacher T, Schreiber S. Improvement of arthritis and arthralgia after treatment with infliximab (Remicade) in a German prospective, open-label, multicenter trial in refractory Crohn's disease. The American journal of gastroenterology. 2002 Oct 1;97(10):2688.
13. Kavita K, Ashvini VR, Ganesh NS. Albumin microspheres. Unique system as drug delivery carriers for non steroidal anti-inflammatory drugs. Int J Pharm Sci Rev Res. 2010; 5(2):10.
14. Virmani T, Gupta J. Pharmaceutical application of microspheres: an approach for the treatment of various diseases. Int J Pharm Sci Res. 2017; 8(8):3253-60.
15. Gullotti E, Yeo Y. Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery. Molecular pharmaceutics. 2009 Aug 3; 6(4):1041-51.
16. Alagusundaram M, Chetty MS, Umashankari K, Badarinath AV, Lavanya C, Ramkanth S. Microspheres as a novel drug delivery system: A review. Int J Chem Tech Res. 2009 Jul; 1(3):526-34.
17. Rathore B, Yadav A, Nayak G, Saraogi GK, Singhai AK. A review on microspheres as drug delivery carriers for management of diabetes mellitus. International journal of pharmacy & life sciences. 2012 Oct 1; 3(10).
18. Prasad BS, Gupta VR, Devanna N, Jayasurya K. Microspheres as drug delivery system-a review. J Glob Trends Pharm Sci. 2014; 5(3):1961-72.
19. Yuen MF, Lai CL. Treatment of chronic hepatitis B: Evolution over two decades. Journal of gastroenterology and hepatology. 2011 Jan; 26:138-43.
20. Prasad SGB, Gupta VRM, Devanna N and Jayasurya K: Microspheres as drug delivery system – A review, JGTPS. 2014; 5(3):1961 -72.
21. Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy. Philadelphia: Lea & Febiger; 1976.
22. Asija R, Sharma D, Mali KR. Solvent evaporation matrix erosion method: a novel approach for floating microsphere development. J Drug Discovery and Therapeutics. 2014; 2(21):24-9.
23. Thanou M, Nihot MT, Jansen M, Verhoef JC, Junginger HE. Mono‐N‐carboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivo. Journal of pharmaceutical sciences. 2001 Jan 1; 90(1):38-46.
24. Gupta R, Pathak K. Optimization studies on floating multiparticulategastroretentive drug delivery system of famotidine. Drug development and industrial pharmacy. 2008 Jan 1; 34(11):1201-8.
25. Patra CN, Dutta P, Sruti J, Rao MB. Floating microspheres: recent trends in the development of gastroretentive floating drug delivery system. International Journal of Pharmaceutical Sciences and Nanotechnology. 2011 May 31; 4(1):1296-306.
26. Mukund JY, Kantilal BR, Sudhakar RN. Floating microspheres: a review. Brazilian Journal of Pharmaceutical Sciences. 2012 ;48:17-30.
27. Kawatra M, Jain U, Ramana J. Recent advances in floating microspheres as gastro-retentive drug delivery system: A review. Int J Recent Adv Pharm Res. 2012 ;2(3):5-23.
28. Cleland JL, Duenas ET, Park A, Daugherty A, Kahn J, Kowalski J, Cuthbertson A. Development of poly-(D, L-lactide–coglycolide) microsphere formulations containing recombinant human vascular endothelial growth factor to promote local angiogenesis. Journal of Controlled Release. 2001 May 14; 72(1-3):13-24.
29. Rastogi V, Shukla SS, Singh R, Lal N, Yadav P. Microspheres: a promising drug carrier. Journal of Drug Delivery and Therapeutics. 2016 May 15; 6(3):18-26.
30. Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, Chang TT, Kitis G, Rizzetto M, Marcellin P, Lim SG, Goodman Z, Wulfsohn MS, Xiong S. Adefovir dipivoxil for the treatment of hepatitis B e antigen–negative chronic hepatitis B. New England Journal of Medicine. 2003 Feb 27; 348(9):800-7.
31. Rizzetto M, Tassopoulos NC, Goldin RD, Esteban R, Santantonio T, Heathcote EJ, Lagget M, Taak NK, Woessner MA, Gardner SD. Extended lamivudine treatment in patients with HBeAg-negative chronic hepatitis B. Journal of hepatology. 2005 Feb 1; 42(2):173-9.
32. Singh C, Purohit S, Singh M, Pandey BL. Design and evaluation of microspheres: A Review. Jddr. 2013; 2(2):18-27.
33. Patel NR, Patel DA, Bharadia PD, Pandya V, Modi D. Microsphere as a novel drug delivery. International Journal of Pharmacy & Life Sciences. 2011 Aug 1; 2(8)..
34. Singh C, Purohit S, Singh M, Pandey BL. Design and evaluation of microspheres: A Review. Jddr. 2013;2(2):18-27.
35. Dhadde GS, Mali HS, Raut ID, Nitalikar MM, Bhutkar MA. A review on microspheres: Types, method of preparation, characterization and application. Asian Journal of Pharmacy and Technology. 2021; 11(2):149-55.
36. Virmani T, Gupta J. Pharmaceutical application of microspheres: an approach for the treatment of various diseases. Int J Pharm Sci Res. 2017;8(8):3253-60.
37. Prasanth VV, Moy AC, Mathew ST, Mathapan R. Microspheres-an overview. International journal of research in pharmaceutical and biomedical sciences. 2011 Apr; 2(2):332-8.
38. Mohan ME, Sujitha HA, Rao VU, Ashok M, Kumar AB. A brief review on mucoadhesive microspheres. IJRRPAS. 2014; 4(1):975-86.
39. Kumar AM, Rao KP. Poly (palmitoyl-L-hydroxyproline ester) microspheres as potential oral controlled drug delivery system. International journal of pharmaceutics. 1997 Apr 14; 149(1):107-14.
40. Shaji J, Poddar A, Iyer S. Brain-targeted nasal clonazepam microspheres. Indian Journal of pharmaceutical Sciences. 2009 Nov; 71(6):715.
41. Chowdary KP, Babu JS. Permeability of ethylene vinyl acetate copolymer microcapsules: Effect of solvents. Indian journal of pharmaceutical sciences. 2003; 65(1):62.
42. Gupta R, Shanthi C, Mahato AG. Characterization of Captopril-Ethyl Cellulose Microspheres by Thermal Analysis. Int. J. Drug Dev. Res. 2010; 2:394-8.
43. Chowdary KP, Babu JS. Permeability of ethylene vinyl acetate copolymer microcapsules: Effect of solvents. Indian journal of pharmaceutical sciences. 2003; 65(1):62.
44. Ayon NJ, Hasan I, Islam MS, Reza MS. Preparation and characterization of gliclazide incorporated cellulosic microspheres: studies on drug release, compatibility and micromeritics. Dhaka University Journal of Pharmaceutical Sciences. 2014; 13(2):149-66.
45. Kakkar V, Wani Su, Gautam Sp, Qadrie Zl. Role of microspheres in novel drug delivery systems: preparation methods and applications. International Journal of Current Pharmaceutical Research. 2020 May 15:10-5.
46. Thota S, Kusuma B, Rarevati M, Narendra P, Babu SM. Formulation and Evaluation of ethyl cellulose microspheres containing diclofenac sodium. International Journal of Research in Pharmaceutical Sciences and Technology. 2021 Oct 25; 2(4).
47. Verma R, Verma S, Kumar S. Microsphere-a novel drug delivery system. Research Chronicle in Health Sciences. 2019 Jul 30; 5(1):5-14.
48. Virmani T, Gupta J. Pharmaceutical application of microspheres: an approach for the treatment of various diseases. Int J Pharm Sci Res. 2017; 8(8):3253-60.
49. Karki R, Jha SK, GS SK, Goli D. Formulation and evaluation of microspheres containing fluvastatin sodium. International Journal of Drug Development and Research. 2012; 4(2):0-.
50. Sailaja AK, Begum N. Formulation and evaluation of cox-2 inhibitor (etoricoxib) loaded ethyl cellulose nanoparticles for topical drug delivery. Nano Biomedicine and Engineering. 2018; 10(1):1-9.
51. Singh C, Purohit S, Singh M, Pandey BL. Design and evaluation of microspheres: A Review. Jddr. 2013; 2(2):18-27.
52. Kreuter J, Nefzger M, Liehl E, CzokR, Voges R. Microspheres – A Novel Approach in Drug Delivery System. J Pharm sci. 1983; 72: 1146
53. Costa P, Lobo JM. Modeling and comparison of dissolution profiles. European journal of pharmaceutical sciences. 2001 May 1; 13(2):123-33.
54. Jain NK, editor. Progress in controlled and novel drug delivery systems. CBS Publishers & Distributors; 2004.
55. Jadhav N, Patel V, Mungekar S, Bhamare G, Karpe M, Kadams V. Microsponge delivery system: an updated review, current status and future prospects. Journal of Scientific and Innovative Research. 2013 Sep 21;2(6):1097-110.
56. Mahapatra Bk, Kumar Shah S, Mohanto S, Mantry S. Preparation Design and In-Vitro Evaluation of Sustained Release Microsphere of Ropinirole Hydrochloride By Emulsion Solvent Evaporation Technique. International Journal of Innovative Pharmaceutical Sciences and Research. 2019 May 27; 7(5):48-60.
57. Rajput S, Agrawal P, Pathak A, Shrivasatava N, Baghel SS, Baghel RS. A review on microspheres: Methods of preparation and evaluation. World journal of pharmacy and pharmaceutical sciences. 2012; 1:422-38.
58. Meghna KS, Pillai K, Giridas S, Sreelakshmi C, Vijayakumar B. Microsphere a drug delivery system–a review. International Journal of Novel Trends in Pharmaceutical Sciences. 2017 Aug 31; 7(4):109-18.
59. Kumar, A., Mahajan, S., & Bhandari, N. Microspheres: a review. World J Pharm Pharm Sci, 2017; 14(6), 724-40.
60. Nikam VK, Gudsoorkar VR, Hiremath SN, Dolas RT, Kashid VA. Microspheres-A Novel drug delivery system: An overview. International journal of pharmaceutical and chemical sciences. 2012 Jan;1(1).
61. Goud CM, Sravan M, Vinod M, Ramana H, Venkateshwarlu G. Invitro Wassh off Comparision Studies of Sodium Alginate Mucoadhesive Microspheres Using Different Polymers.
62. Hafeli U. Physics and Chemistry Basic of Biotechnology. Focus on biotechnology. Review. Radioactive Microspheres for Medical Application. 2002; 7:213-48.
63. Khan MS, Doharey V. A review on nasal microsphere. International Journal of Pharma Sciences. 2014; 4:496-506.
Published
2022-12-14
How to Cite
Galande, P., Yadav, V., & Borkar, S. (2022). A Review on Microspheres: Preparation, Characterization and Applications. Asian Journal of Pharmaceutical Research and Development, 10(6), 128–133. https://doi.org/10.22270/ajprd.v10i6.1204
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Review Articles
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