The A Research Article on Antistress Activity of Herbal Extract Oil of Piper Methysticum on Wistar Albino

  • Ankit Sharma Kota College of Pharmacy, Kota, Rajasthan, India
  • Mohammad Mukim Kota College of Pharmacy, Kota, Rajasthan, India
  • Rahul Ancheria Kota College of Pharmacy, Kota, Rajasthan, India
  • Hrishab Jangid Kota College of Pharmacy, Kota, Rajasthan, India

Abstract

The research was carried out to determine the antistress activity of piper methysticum and the animal model used was wistar albino due to it’s worldwide acceptability in researches related to psychology .kava (piper methysticum) root  extract was used for abundance of kavlactones hence for the sake of study different percentage of suspensions like 4%, 6%, 8%, 12%, 18%, 30% were prepared and diazepam was selected as standard drug.oecd guideline 423 was followed during acute toxicity studies.no symptoms of acute toxicity was seen during 14 days observational period when given a dose of 2000 mg/kg so on this basis two dose level of 200mg/kg and  400 kg were selected for antistress activity.test model selected for antistress activity were  forced swim test, tail suspension test and anoxia stress tolerance test.for respective tests a sharp decline in duration of immobility and increase in anoxia stress tolerance was seen.hence we can conclude that piper methysticum can play a significant role in the field of treating stress after futhur  extensive clinical research.


 

Keywords: antistress, kava, oecd, wistar albino

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Author Biographies

Ankit Sharma, Kota College of Pharmacy, Kota, Rajasthan, India

Kota College of Pharmacy, Kota, Rajasthan, India

Mohammad Mukim, Kota College of Pharmacy, Kota, Rajasthan, India

Kota College of Pharmacy, Kota, Rajasthan, India

Rahul Ancheria, Kota College of Pharmacy, Kota, Rajasthan, India

Kota College of Pharmacy, Kota, Rajasthan, India

Hrishab Jangid, Kota College of Pharmacy, Kota, Rajasthan, India

Kota College of Pharmacy, Kota, Rajasthan, India

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How to Cite
Sharma, A., Mukim, M., Ancheria, R., & Jangid, H. (2021). The A Research Article on Antistress Activity of Herbal Extract Oil of Piper Methysticum on Wistar Albino. Asian Journal of Pharmaceutical Research and Development, 9(1), 117-129. https://doi.org/https://doi.org/10.22270/ajprd.v9i1.892