Pharmacognostical Standardization, Phytochemical Screening and Antiulcer Activity of Terminalia bellerica

  • Srishti Upadhyay Department of Pharmacology, Kota College of Pharmacy, Kota
  • Jagdish Nagar Department of Pharmacology, Kota College of Pharmacy, Kota
  • Mohammad Mukim Department of Pharmacology, Kota College of Pharmacy, Kota

Abstract

Context: Terminalia chebula Retz. (Combretaceae) is a medium-sized tree that grows in the wild throughout India. T. chebula has been extensively used in Ayurveda, Unani, and homoeopathic medicine. The fruit has been used as a traditional medicine for a household remedy against various human ailments. Traditionally T. chebula is used to cure chronic ulcer, gastritis, and stomach cancers.


Objective: The present study is to evaluate the antiulcer effect of hydroalcoholic extract of Terminalia chebula fruit.


Materials and methods: In the pharmacognostical, phytochemical and biological evaluation many chemicals, glassware and instruments were used. Different grades of chemicals were used as per the requirement like laboratory reagent (LR), analytical reagents (AR) and HPLC.


Conclusion : The present study has been done to evaluate the antiulcer effect of METB on indomethacin induced ulcer models at various doses. The results obtained from the present study have shown that METB possesses antiulcer effect on indomethacin induced ulcers.  Pre-treatment with METB particularly at a dose of 50mg/kg, 100mg/kg and 200 mg/kg decreases ulcer index, total acidity, total volume of acid secretion and increase in pH when compared with control.


 

Keywords: Pharmacognostical, Phytochemical, Terminalia chebula.

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Author Biographies

Srishti Upadhyay, Department of Pharmacology, Kota College of Pharmacy, Kota

Department of Pharmacology, Kota College of Pharmacy, Kota

Jagdish Nagar, Department of Pharmacology, Kota College of Pharmacy, Kota

Department of Pharmacology, Kota College of Pharmacy, Kota

Mohammad Mukim, Department of Pharmacology, Kota College of Pharmacy, Kota

Department of Pharmacology, Kota College of Pharmacy, Kota

References

1. Chaturvedi A, Kumar MM, Bhawani G, Chaturvedi H, Kumar M, Goel KR. Effect of ethanolic extract of Eugenia Jambolana seeds on gastric ulceration and secretion in rats. Indian J Physiol Pharmacol 2007; 51(2):131-140.
2. Merseresu WA, Hinchey EJ. Role of gastric mucosal folds in formation of local ulcers in the rat. Surgery 1982; 91:150-155.
3. Takeuchi K, Ueki S, Okabe S. Importance of gastric motility in the pathogenesis of indomethacine-induced gastric lesions in rats. Dig Dis Sci 1986; 32:1114-1122.
4. Garrick T, Buack S, Bass P. Gastric motility is a major factor in cold restraint induced lesion formation in rats. Am J Physiol1986; 250: 6191-6199.
5. Takeuchi K, Nobuhara Y. Inhibition of gastric motor activity by 16, 16-dimethyl prostaglandin E2: a probable explanation of cytoprotective. Dig Dis Sci 1985; 32:1181-1188.
6. Shetty R, Kumar KV, Naidu MUR, Ratnakar KS. Effect of Ginkgo biloba extract on ethanol induced gastric mucosal lesions in rats. Indian J Pharmacol 2000; 32:313-7.
7. Al-Harbi MM, Quershi S, Raza M, Ahmed MM, Afzal M, Shah AH. Gastric antiulcer and cytoprotective effect Commiphora molmol in rats. J Ethnopharmacol 1997; 55:141-50.
8. Vanisree AJ, Mitra K, Shyamala Devi CS. Antiulcerogenic effect of UL-409 against experimentally induced gastric ulcer in rats. Indian J Pharmacol 1996; 28:265-8.
9. Hollander D, Taranawski A, Gergely H, Zipser KD. Sucralfate protection of the gastric mucosa against alcohol-induced injury: A prostaglandin-mediated process. Scand J Gastroenterol 1984; 101:97-102.
10. MillerTA, Henagan JM. Indomethacin decreases resistance of gastric barrier disruption by alcohol. Dig Dis Sci 1984; 29:141-9.
11. Takeuchi K, Ueshima K, Ohuchi T and Okabe S. The role of Capsaicin sensitive sensory neurons in healing of HCl-induced mucosal lesions in rats. Gastroenterology 1994; 104:15-24.
12. Goodman, Gillman. The Pharmacological Basis of Therapeutics. 9thed. New York: McGraw-Hill; 1996. p. 902-903.
13. Sedlak J, Lindsay RH. Estimation of total protein and non protein sulfhydryl in tissue with Ellman’s reagent. Anal Biochem1968; 25:192.
14. Ogle CW, Koo MWL, Cho CH, Tong M. The influence of Verapamil on the gastric effects of stress in rats. Eur J Pharmacol 1985; 11(2): 399-404.
15. Grossman MI. Control of gastric secretion in gastrointestinal disease, Pathophysiology - diagnosis and management. Sleisenzer MH, Fordtran JS, editors. 2ed. Philadelphia: W B Saunders Co; 1978. p. 640-659.
16. Mizushima Y, Kobayashi M. Interaction of anti-inflammatory drugs with serum proteins, especially with some biologically active proteins. J Pharm Pharmacol1967; 20:169.
17. Olsen CE. Glutathione modulates toxic oxygen metabolite injury of canine chief cell primary culture. Am J Physiol 1988; 254:649-656.
18. Lüllmann H, Mohr K, Ziegler A, Bieger D. Color Atlas of Pharmacology. 2nded. New York: Thieme Stuttgart; 2000. p. 166.
19. Body SC, Sasame HA, Body MR. Gastric glutathione depletion and acute ulcerogenesis by diethylmaleate given subcutaneously to rats. Life Sci1981; 28:2987-92.
20. Lau WY, Leow CK. History of perforated duodenal and gastric ulcers. World J Surg. 1997; 21:890–6.
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How to Cite
Upadhyay, S., Nagar, J., & Mukim, M. (2022). Pharmacognostical Standardization, Phytochemical Screening and Antiulcer Activity of Terminalia bellerica. Asian Journal of Pharmaceutical Research and Development, 10(2), 125-137. https://doi.org/https://doi.org/10.22270/ajprd.v10i2.1119