Vigna Comosa Baker Aerial Part’s Extracts Effects on Hyperglycemia and Hepatic Glucose’sliberation

  • Kotin Mahoutin Lucrèce Physiology of effort Research Unit of the National Institute of Youth, Physical Education and Sport (University of  Abomey-Calavi), 01 BP 169 Porto-Novo, Republic of Beni
  • Ahounouaikpe Fifamin Judith Physiology of effort Research Unit of the National Institute of Youth, Physical Education and Sport (University of  Abomey-Calavi), 01 BP 169 Porto-Novo, Republic of Benin.
  • Akakpo Baï Huguette Physiology of effort Research Unit of the National Institute of Youth, Physical Education and Sport (University of  Abomey-Calavi), 01 BP 169 Porto-Novo, Republic of Benin.
  • Assogba Mahoudo Fidèle Laboratory of Pharmacognosy and Essential Oils of the Faculties of Health Sciences and Science and Technology  (University of Abomey-Calavi), 01 BP 188 Cotonou, Republic of Benin
  • Dansou Houndjovi Pierre Physiology of effort Research Unit of the National Institute of Youth, Physical Education and Sport (University of  Abomey-Calavi), 01 BP 169 Porto-Novo, Republic of Benin.
  • Gbenou Joachim Djimon Laboratory of Pharmacognosy and Essential Oils of the Faculties of Health Sciences and Science and Technology  (University of Abomey-Calavi), 01 BP 188 Cotonou, Republic of Benin

Abstract

Vignacomosa Baker (V. Comosa) is a plant used by Beninese Oueme department’s populationfor the treatment of diabetes without any scientific study showing its effectiveness. The objective of this study is to investigate the effects of theextracts of V. Comosaon hyperglycemic rabbits by Oral Glucose Tolerance Test (OGTT) and on hepatic glucose liberation. Phytochemical screening revealed that the plant contains alkaloids, tannins, flavonoids, mucilage, triterpenoids, steroids, reducing compounds, saponins, oses and holosides.Cytotoxity test showed that those extracts were free of toxicity. The extracts showed anti-hyperglycemic activities doses and time depending. The effective doses are 500 mg/kg for the aqueous extract and 1000 mg/kg for the ethanolic extract. The extracts are effective as compared with glibenclamide (reference product). Moreover, the ex vivo test conducted on the liver revealed that V. Comosa aqueous extract inhibits the hepatic glucose liberation and 500 mg/mL is the most effective dose. The results of this study account for the plant under consideration of its traditional usage in the treatment of diabetes.


 

Keywords: Vignacomosa, extracts, phytochemistry,cytotoxicity,hyperglycemia, hepatic glucose.

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Author Biographies

Kotin Mahoutin Lucrèce, Physiology of effort Research Unit of the National Institute of Youth, Physical Education and Sport (University of  Abomey-Calavi), 01 BP 169 Porto-Novo, Republic of Beni

Physiology of effort Research Unit of the National Institute of Youth, Physical Education and Sport (University of

 Abomey-Calavi), 01 BP 169 Porto-Novo, Republic of Beni

Ahounouaikpe Fifamin Judith, Physiology of effort Research Unit of the National Institute of Youth, Physical Education and Sport (University of  Abomey-Calavi), 01 BP 169 Porto-Novo, Republic of Benin.

Physiology of effort Research Unit of the National Institute of Youth, Physical Education and Sport (University of

 Abomey-Calavi), 01 BP 169 Porto-Novo, Republic of Benin.

Akakpo Baï Huguette, Physiology of effort Research Unit of the National Institute of Youth, Physical Education and Sport (University of  Abomey-Calavi), 01 BP 169 Porto-Novo, Republic of Benin.

Physiology of effort Research Unit of the National Institute of Youth, Physical Education and Sport (University of

 Abomey-Calavi), 01 BP 169 Porto-Novo, Republic of Benin.

Assogba Mahoudo Fidèle, Laboratory of Pharmacognosy and Essential Oils of the Faculties of Health Sciences and Science and Technology  (University of Abomey-Calavi), 01 BP 188 Cotonou, Republic of Benin

Laboratory of Pharmacognosy and Essential Oils of the Faculties of Health Sciences and Science and Technology

 (University of Abomey-Calavi), 01 BP 188 Cotonou, Republic of Benin

Dansou Houndjovi Pierre, Physiology of effort Research Unit of the National Institute of Youth, Physical Education and Sport (University of  Abomey-Calavi), 01 BP 169 Porto-Novo, Republic of Benin.

Physiology of effort Research Unit of the National Institute of Youth, Physical Education and Sport (University of

 Abomey-Calavi), 01 BP 169 Porto-Novo, Republic of Benin.

Gbenou Joachim Djimon, Laboratory of Pharmacognosy and Essential Oils of the Faculties of Health Sciences and Science and Technology  (University of Abomey-Calavi), 01 BP 188 Cotonou, Republic of Benin

Laboratory of Pharmacognosy and Essential Oils of the Faculties of Health Sciences and Science and Technology

 (University of Abomey-Calavi), 01 BP 188 Cotonou, Republic of Benin

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How to Cite
Lucrèce, K., Judith, A., Huguette, A., Fidèle, A., Pierre, D., & Djimon, G. (2021). Vigna Comosa Baker Aerial Part’s Extracts Effects on Hyperglycemia and Hepatic Glucose’sliberation. Asian Journal of Pharmaceutical Research and Development, 9(2), 11-17. https://doi.org/https://doi.org/10.22270/ajprd.v9i2.965