Mucoadhesive polymers for buccal drug delivery system: An overview

  • Mukesh Sharma Department of Pharmaceutics, Mallige College of Pharmacy, Banglore-560090, Karnataka, India.
  • F.R. Sheeba Department of Pharmaceutics, Mallige College of Pharmacy, Banglore-560090, Karnataka, India.
  • Rajkumar Prasad Yadav Department of Pharmaceutics, Mallige College of Pharmacy, Banglore-560090, Karnataka, India.
  • Akshay Kumar Patel Department of Pharmaceutics, Mallige College of Pharmacy, Banglore-560090, Karnataka, India.
  • Yeshavantha Kumar Department of Pharmaceutics, Mallige College of Pharmacy, Banglore-560090, Karnataka, India.

Abstract

Pharmaceutical scientists around the globe have been seeking to discover as an alternative to injections over the last few, transdermal and transmucosal routes decades. The buccal cavity mucosa the most convenient and easily available site for the distribution of local and systemic therapeutic agents was found to be dosage forms among the numerous transmucosal sitesavailable.Theories and various polymers used in mucoadhesive drug delivery. Mucoadhesive polymers increases the residence time, prolong the absorption, enhances solubilityand dissolution characteristics of poorly soluble drugs. In addition, we are focused on the latest generation of mucoadhesion polymers, led by the latest formulation of mucoadhesive for the distribution of oral drugs, such as thiolated polymers. A good insight into mucoadhesion polymers, the mucoadhesive phenomenon and the factors that can affect polymer mucoadhesion is given in the current analysis. The systematic drug delivery has been investigated for buccal mucosa and local drug treatment or therapy is subjected to first pass metabolism. Oral mucosa drug delivery by discussing the structural features of mucosa, mechanism of mucoadhesion. General consideration in design of mucoadhesive buccal dosage forms, permeation enhancers and the various evalution method along with literature survey of the buccal mucoadhesive.


 

Keywords: Mucoadhesive polymer, oral mucosa, enhances solubility, drug delivery, permeation enhancer.

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Author Biographies

Mukesh Sharma, Department of Pharmaceutics, Mallige College of Pharmacy, Banglore-560090, Karnataka, India.

Department of Pharmaceutics, Mallige College of Pharmacy, Banglore-560090, Karnataka, India.

F.R. Sheeba, Department of Pharmaceutics, Mallige College of Pharmacy, Banglore-560090, Karnataka, India.

Department of Pharmaceutics, Mallige College of Pharmacy, Banglore-560090, Karnataka, India.

Rajkumar Prasad Yadav, Department of Pharmaceutics, Mallige College of Pharmacy, Banglore-560090, Karnataka, India.

Department of Pharmaceutics, Mallige College of Pharmacy, Banglore-560090, Karnataka, India.

Akshay Kumar Patel, Department of Pharmaceutics, Mallige College of Pharmacy, Banglore-560090, Karnataka, India.

Department of Pharmaceutics, Mallige College of Pharmacy, Banglore-560090, Karnataka, India.

Yeshavantha Kumar, Department of Pharmaceutics, Mallige College of Pharmacy, Banglore-560090, Karnataka, India.

Department of Pharmaceutics, Mallige College of Pharmacy, Banglore-560090, Karnataka, India.

References

1. Punitha S, Girish Y. Polymers in mucoadhesive buccal drug delivery system: A review. Int J Res Pharm Sci. 2010; 1(2):170-86.
2. Yadav V.K, Gupta A.B, Kumar R, Yadav J.S, Kumar B. Mucoadhesive polymers means of improving the mucoadhesive properties of drug delivery system. J Chem Pharm Res. 2010; 2(5):418-32.
3. Anil A, Sudheer P. Mucoadhesive polymers: A review. J Pharm Res. 2018; 17(1):48-54.
4. Shridhar G.S, Monahar S.D, Bhanudas R. Mucoadhesive buccal drug delivery: An review. J Adv Pharm Edu Res. 2013; 4(3): 319- 32.
5. Vidyasable, Khade A, Gadge G, Mahajan U. An overview on natural polymer based mucoadhesive buccal films for controlled drug delivery. Int J Pharm Res Tech. 2020; 10 (1): 48-57.
6. Parmar H. K, Pandya K.K, Pardasani L.J, Panchal V.S, Tandel T. A systematic review on mucoadhesive drug delivery system. World J Pharm Res. 2017; 6(9): 337-66.
7. Carvalho F.C, Bruchi M.L, Evangelista R.C, Gremiao M. P. D. Mucoadhesive drug delivery system. Brazil J Pharm Sci. 2010; 46(1): 1-17.
8. Puri V, Sharma A, Maman P, Rathore N, Singh I. Overview of mucoadhesive biopolymers for buccal drug delivery systems. Int J App Pharm. 2019; 11(6): 18-29.
9. Garg A, Garg S, Kumar M, Kumar S, Shukla A.K, Kaushik S.P.C. Application of natural polymers in mucoadhesive drug delivery. Adv Pharm J. 2018; 3(2): 38-42.
10. Gilhotra R.M, Ikram M, Srivastava S, Gilhotra N. A clinical perspective on mucoadhesive buccal drug delivery systems. J Bio Res. 2014; 28(2): 87-97.
11. Singh R, Sharma D, Gang R. Review on mucoadhesive drug delivery system with special emphasis on buccal route: An important tool in designing of novel controlled drug delivery system for the effective delivery of pharmaceuticals. J Dev Drug. 2017; 6(1): 1-12.
12. Ashis B, Budharani, Ajay K, Shadija. Mucoadhesive buccal drug
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How to Cite
Sharma, M., Sheeba, F., Yadav, R., Patel, A., & Kumar, Y. (2021). Mucoadhesive polymers for buccal drug delivery system: An overview. Asian Journal of Pharmaceutical Research and Development, 9(2), 57-64. https://doi.org/https://doi.org/10.22270/ajprd.v9i2.938