Chrysophyllum Albidum and Its Potential Damage to the Kidney of Wistar Rats
Objective: The study was aimed at determining the effect of graded doses of Chrysophyllumalbidum on the kidney.
Materials and Methods: Twenty wistar rats (190-220 grams) were used in this study and they were randomly allocated into four groups of five rats each. Group A received food and distilled water only while groups B, C and D were treated with 100 mg/kg, 200 mg/kg 300 mg/kg of Chrysophyllumalbidum leaf extract respectively. The study lasted for three weeks after which the animals where sacrificed and their blood samples and kidney collected for examination.
Results: The result from this study showed a significant decrease (p<0.05) in body weight in group of all treated groups. Also, there was a significant increase (p<0.05) in kidney weight in group C but a non-significant increase (p>0.05) in group B and D when compared to group A. In addition, the serum urea and creatinine level showed a significant decrease (p<0.05) in the treated groups when compared with that of group A. Histopathological findings revealed a mild to moderate changes in the cytoarchitecture of the kidney.
Conclusion: This result of this study suggests that ethanolic leaf extract of Chrysophyllumalbidum may have the tendency of being toxic to the kidney tissue when consumed at higher doses.
2. Arueya G.L, Ugwu G.F. Development and evaluation of African star apple (Chrysophyllum albidum) based food supplement and its potential in combating oxidative stress. J.Funct. Foods 2017; 33:376-385.
3. Adebayo A.H, Abolaji A.O, Opata T.K, Adegbenro I.K. Effects of ethanolic leaf extract of Chrysophyllum albidum G. on biochemical and haematological parameters of albino Wistar rats. Afr. J.Biotechnol. 2010; 9(14): 2145-2150.
4. Amusa N.A, Ashaye O.A, Oladapo M.O. Biodeterioration of the African star apple (Chrysophyllum albidum) in storage and the effect on its food value. Afr. J. Biotechnol. 2013; 2:56-59.
5. Emudainohwo J, Erhirhie E, Moke E, Edje K. a comprehensive Review on ethno-medicine, phytochemistry and ethnopharmacology of Chrysophyllum albidum. J. Adv Med Pharm Sci. 2015; 3:147 – 154.
6. Abiodun O.A, Oladapo A.S. Physicochemical properties of African star apple (Chrysophylum albidum) components. Nutr. Food Sci. 2011; 41:8-11.
7. Adewusi H.A. The African Star Apple Chrysophyllum albidum Indigenous Knowledge from Ibadan, Southwestern Nigeria. In:Proceedings of a National Workshop on the Potentials of the SatrApple in Nigeria. (Eds.) Denton OA, Ladipo DO, Adetoro MA, SarumiMB 1997, p. 25-33.
8. Adepoju O.T, Adeniji T.P.O. Nutrient composition and micronutrient potential of three wildly grown varieties of African star apple (Chrysophyllum albidum) from Nigeria. Afr. J. Food Sci. 2012; 6:344-351.
9. Onyeka C.A, Aligwekwe A.U, Nwakanma A.A, Bakare A.A, Ofoego U.C. Effects of ethanolic root bark extract of Chrysophyllum albidum on serum superoxide Dismutase, catalase and Malondialdehyde in rat. Int J PharmaSci Res. 2012; 3:347 – 351.
10. Akaneme F.I. Identification and preliminary phytochemical analysis of herbs that can arrest threatened miscarriage in Orba and Nsukka towns of Enugu State. Afr. J. Biotechnol. 2008; 7: 6-11.
11. George O.A, Adenipekun E.O, Fasogbon S.A, Oparanozie J.A. Antimicrobial Activities of Chrysophyllum albidum Leaves, Fruits and Seeds. Am. J. Biomed. Sci. 2018; 10:28-44.
12. Okoli B.J and Okere O.S. Antimicrobial activity of the phytochemical constituents of Chrysophyllum albidum G. Don Holl (African star apple) plant. J. Res. Nat. Dev. 2010; 8(1):11-16.
13. National Institute of Health (NIH). Guide for the care and use of laboratory Animals. Department of Health Education and Welfare, 1985; p.85 – 123.
14. Larsen K. Creatinine assay by a reaction-kinetic principle. Clin. Chim. Acta 1971; 41:209-217.
15. Weatherburb M.W. Urease-Berthelot Colorimetric Method for in vitro Determination of Urea. Anal. Chem. 1967; 39: 971 – 974.
16. Arthur S.J, John B. a colour Atlas of histopathological staining techniques. London: Wolf Medical Publisher Limited; 1978. p. 14 – 20
17. Gounden V, Jialal I. Renal Function Test. start Pearls Publishing 2019 [online]. Available at https://www.ncbi.nlm.nih.gov/books/NBK507821/ [Accessed 24 January, 2020].
18. Guo C, Yang J, Wei J, Li Y, Xu J, Jiang Y. Antioxidant activities of peel, pulp and seed fractions of common fruits as determined by FRAP assay. Nutr. Res. 2003; 23:1719-1726.
19. Akin-Osanaiye B.C, Gabriel A.F, Salau T.O, Murana O.O. Chrysophyllum albidum seed (African star apple) as an additive in agricultural feed and a potent antimicrobial. Direct Res. J. Agric. Food Sci. 2018; 6(5):107-113.
20. Azor A, Kolade J, Adebisi. Utilization of African star apple (Chrysopyllum albidum) kernel meal in broiler diets. J. Agric. Sci. 2017; 62(2):143-154.
21. Aliyu R, Adebayo A.H, Gatsing D, Garba I.H. The Effects of Ethanolic Leaf Extract of Commiphora africana (Burseraceae) on Rat Liver and Kidney Functions. J. Pharmacol. Toxicol. 2006; 2:373-379
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