Ethosomal Drug Delivery System: A Newer Approach

Authors

  • Naresh Kalra Faculty of Pharmacy, Lords University, Alwar
  • Suresh Choudhary Faculty of Pharmacy, Lords University, Alwar
  • Pankaj Arora Faculty of Pharmacy, Lords University, Alwar
  • Namita Arora Faculty of Pharmacy, Lords University, Alwar

DOI:

https://doi.org/10.22270/ajprd.v8i5.835

Keywords:

Ethosomes, Non- Invasive, Ethosomal carrier, Ethanol.

Abstract

The transdermal drug delivery system is a technique that provides advantages over conventional administration routes such as intravenous ororal route. Ethosomes are non-invasive delivery carriers that enables drugs to reach the deep skin layers and the systemic circulation. Ethosomal systems are conceptually sophisticated, they are simple in their preparation, safe for use a combination that can highly expand their application. Ethosomes are soft, malleable vesicles tailored for enhanced delivery of active agents. The size range of ethosomes may vary from tens of nanometres (nm) to microns (µm). Ethosomes formulation are convenient for use & harmlessness to skin.

 

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Author Biographies

Naresh Kalra, Faculty of Pharmacy, Lords University, Alwar

Faculty of Pharmacy, Lords University, Alwar

Suresh Choudhary, Faculty of Pharmacy, Lords University, Alwar

Faculty of Pharmacy, Lords University, Alwar

Pankaj Arora, Faculty of Pharmacy, Lords University, Alwar

Faculty of Pharmacy, Lords University, Alwar

Namita Arora, Faculty of Pharmacy, Lords University, Alwar

Faculty of Pharmacy, Lords University, Alwar

References

1. Kirjavainen M, Urtti A, Jaaskelainen I, et al. Interaction of liposomes with human skin in vitro—the influence of lipid composition and structure. BiochimBiophys Acta. 1996; 1304:179Y189.
2. Paolino D, Lucania G, Mardente D, Alhaique F, Fresta M. Ethosomes for skin delivery of ammonium glycyrrhizinate: in vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers. J Control Release. 2005; 106:99Y110.
3. Lopez-Pinto JM, Gonzalez-Rodriguez ML, Rabasco AM. Effect of cholesterol and ethanol on dermal delivery from DPPC liposomes. Int JPharm. 2005; 298:1Y12.
4. Michaels AS, Chandrasekaran SK, Shaw JW. Drug permeation through human skin: theory and in vitro ex-perimental measurement. AlChE 1975; 21:985-96.
5. Indora N, Kaushik D. Design, development and evaluation of ethosomal gel of fluconazole for topical fungal infection. International Journal of Engineering Science Invention Research & Development, 2015; I(Viii).
6. He R, Cui D xiang, Gao F. Preparation of fluorescence ethosomes based on quantum dots and their skin scar penetration properties. Mater Lett. 2009; 63(20):1662–4
7. Gangwar S., Singh S., Garg G., Ethosomes: A Novel Tool for Drug Delivery Through the Skin, Journal of Pharmacy Research 2010; 3(4):688-691.
8. Laib S, Routh A F. Fabrication of colloidosomes at low temperature for the encapsulation of thermally sensitive compounds. J. Colloid & Interface Sci. 2008; 317:121-129.
9. Swarnlata S, Rahul R, Chanchal D.K, Shailendra S. Colloidosomes an advanced vesicular system in drug delivery. Asian J.Sci. Research 2011; 4(1):1 – 15.
10. Transdermal Delivery of Ciclopirox Olamine via Ethosomal and Liposomal Carrier, Research Journal of Pharmacy and Technology. 2011; 4(8):1207–11.
11. Fan C, Li X, Zhou Y, Zhao Y, Ma S, Li W, et al. Enhanced topical delivery of tetrandrine by ethosomes for treatment of Arthritis. Biomed Res Int. 2013
12. Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. Ethosomes — novel vesicular carriers for enhanced delivery: characterization and skin pen¬etration properties. J Control Release. 2000; 65(3):403–418.
13. Sarwa KK, Suresh PK, Rudrapal M, Verma VK. Penetration of tamoxifen citrate loaded ethosomes and liposomes across human skin: a comparative study with confocal laser scanning microscopy. Curr Drug Deliv. 2014; 11(3):332–337.
14. Jain S, Patel N, Madan P, Lin S. Quality by design approach for for-mulation, evaluation and statistical optimization of diclofenac-loaded ethosomes via transdermal route. Pharm Dev Technol. 2015; 20(4):473–489.
15. Zhang Z, Wo Y, Zhang Y, et al. In vitro study of ethosome penetration in human skin and hypertrophic scar tissue. Nanomedicine. 2012; 8(6):1026–1033.
16. Mishra D, Mishra PK, Dabadghao S, Dubey V, Nahar M, Jain NK. Comparative evaluation of hepatitis B surface antigen-loaded elastic liposomes and ethosomes for human dendritic cell uptake and immune response. Nanomedicine. 2010; 6(1):110–118.
17. Song CK, Balakrishnan P, Shim CK, Chung SJ, Chong S, Kim DD. A novel vesicular carrier, transethosome, for enhanced skin delivery of voriconazole: characterization and in vitro/in vivo evaluation. Colloids Surf B Biointerfaces.2012; 92:299-304.
18. Williams ML, Elias PM. The extracellular matrix of stratum corneum: role of lipids in normal and pathological function. Crit rev Therapy drug carrier Systems 1987; 3:95–122.
19. Touitou E, Godin B, Weiss C. Enhanced delivery of drugs into and across the skin by ethosomal carriers. Drug Dev Res 2000a; 50: 406-15.
20. Touitou E, inventor. Composition of applying active substance to or through the skin. US patent 5 540 934, July 30, 1996.
21. KundlikGirhepunj, Ranju Pal, Hitesh Gevariya, Atanu-kumar Behera, Thirumoorthy N. Ethosomes: A Novel Vesicular Carrier for Enhanced Dermal Delivery of Cic-lopirox Olamine. Der Pharm Let 2010; 2(1):360-367.
22. Akiladev D, Basak S, (2010) International Journal of Current pharmaceutical research. 2(4): 1-4.
23. Godin B, TauitouElka. Current Drug Delivery. 2005; 2:269‐275.
24. Biana Godin, ElkaTauitou. Erythromycin Ethosomal Systems: Physiochemical Characterization and En-hanced Antibacterial Activity. Curr Drug Delivery 2005; 2:269-275.
25. Touitou E, Nava Dayan. Carriers for skin delivery of Trihexyphenidyl Hcl: ethosomes vs liposomes. Bioma-terials 2000b; 21: 1879-1885.
26. New RRC. Preparation of liposomes and size determination, In:Liposomes A Practical Approach. New RRC (Ed.), Oxford University Press, Oxford, 1990; 36-39.
27. Akiladev D, Basak S, International Journal of Current pharmaceutical research. 2010; 2(4): 1-4.
28. El. Maghraby GMM, Williams AC, Barry BW. Oestradiol skin delivery from ultradeformable liposomes: re-finement of surfactant concentration.Int J Pharm 2000; 196:63-74.
29. Jain S, Jain P, Jain NK. Transfersomes: a novel vesicular carrier for enhanced transdermal delivery: development, characterization and performance evaluation. Drug Dev Ind Pharm 2003; 29:1013-1026.

Published

2020-10-15

How to Cite

Kalra, N., Choudhary, S., Arora, P., & Arora, N. (2020). Ethosomal Drug Delivery System: A Newer Approach. Asian Journal of Pharmaceutical Research and Development, 8(5), 158–162. https://doi.org/10.22270/ajprd.v8i5.835