Estimation and Evaluation of Brain Biogenic Amines for Anticonvulsant Activity Of Annona Squamosa Linn. Leaves in Mice

Authors

  • Mayur Porwal Department of Pharmacology, School of Pharmaceutical Sciences, IFTM University, Moradabad (U.P)
  • K Sharma Department of Pharmacology, Bhupal’s Noble College of Pharmacy, Udaipur (Raj.)
  • P.K. Sharma Department of Pharmacology, Mharishi Arvind Institute of Pharmacy, Jaipur (Raj.)

Keywords:

Annona squamosa, Catecholamines, GABA, Pentylenetetrazol

Abstract

The ethanol extract of the leaves of Annona squamosa Linn. showed marked protection against convulsions induced by chemo convulsive agents in mice. The catecholamines contained were significantly increased in the processed extract treated mice. The amount of GABA, which is most likely to be involved in seizure activity, was increased significantly in mice brain after six week treatment. Results of the present study revealed that the processed extract showed a significant anticonvulsive property by altering the level of catecholamine and brain amino acids in mice.

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Published

2013-03-01

How to Cite

Porwal, M., Sharma, K., & Sharma, P. (2013). Estimation and Evaluation of Brain Biogenic Amines for Anticonvulsant Activity Of Annona Squamosa Linn. Leaves in Mice. Asian Journal of Pharmaceutical Research and Development, 1(2), 92–95. Retrieved from https://ajprd.com/index.php/journal/article/view/52

Issue

Volume 1st, Issue 2nd, Mar-Apr 2013

Section

Research Articles

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