Review on Corosolic Acid:Based on Various Pharmaceutical Effects
DOI:
https://doi.org/10.22270/ajprd.v7i3.516Keywords:
corosolic acid, banaba, Lagerstroemia speciosa, pharmaceutical effectsAbstract
Corosolic acid is a pentacyclic triterpene acid found in banaba leaves, Lagerstroemia speciosa which is similar in structure to useful pharmaceutical material such as ursolic acid and has been reported to have beneficial activities, as found in in vitro and several animal studies including human studies, particularly due to its effects on lowering of blood sugar. This review paper is focused on various pharmaceutical effects including decreasing of blood sugar of corosolic acid from published articels and can be helpful on the understanding of those effects which can be appliable on maintenace and treatment against several diseas
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References
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7. Yamada K, Hosokawa M, Fujimoto S, Fujiwara H, Fujita Y, Harada N, Yamada C, Fukushima M, Ueda N, Kaneko T, Matsuyama F, Yamada Y, Seino Y, Inagaki N.Effect of corosolic acid on gluconeogenesis in rat liver. Diabetes Research and Clinical Practice. 2008; 80(1):48-55.
8. Klein G, Kim J, Himmeldirk K, Cao Y, Chen X. Antidiabetes and anti-obesity activity of Lagerstroemia speciosa. Evidence-Based Complement and Alternative Medicine. 2007; 4(4):401-7.
9. Hou W, Li Y, Zhang Q, Wei X, Peng A, Chen L, Wei Y. Triterpene acids isolated from Lagerstroemia speciosa leaves as α-glucosidase inhibitors. Phytotherapy research. 2009; 23(5):614-8.
10. Ahn KS, Hahm MS, Park EJ, Lee HK, Kim IH. Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent. Planta Medica. 1998; 64(5):468-70.
11. Akihisa T, Kama S, Uchiyama T. Cytotoxic activity of Perilla frutescens var. japonica leaf extract is due to high concentractions of oleanolic and ursolic acids. Journal of Natural Medicine. 2006;60(4):331-3.
12. Kim JH, Kim YH, Song GY, Kim DE, Jeong YJ, Liu KH, Chung YH, Oh S.Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of β-catenin degradation. Food and Chemical Toxicology.2014; 67:87-95.
13. Fujiwara Y, Takaishi K, Nakao J, Ikeda T, Katabuchi H, Takeya M, Komohara Y.Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling. Oncology Letters.2013; 1619-23.
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17. Yamaguchi Y, Yamada K, Yoshikawa N, Nakamura K, Haginaka J, Kunitomo M. Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome. Life Sciences. 2006;79(26):2474-9.
18. Na M, Yang S, He L, Oh H, Kim BS, Oh WK, Kim BY, Ahn JS.Inhibition of protein tyrosine phosphatase 1B by ursane-type triterpenes isolated from Symplocos paniculata . Planta Medica. 2006; 72(3):261-3.
19. Jang DS, Lee GY, Kim J, Lee YM, Kim JM, Kim YS, Kim JS.A new pancreatic lipase inhibitor isolated from the roots of Actinidia arguta. Archives of Pharmacal Research. 2008; 31(5):666-70.
20. Yamada K, Hosokawa M, Yamada C, Watanabe R, Fujimoto S, Fujiwara H, Kunitomo M, Miura T, Kaneko T, Tsuda K, Seino Y, Inagaki N.Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice. Biological and Pharmceutical Bulletin. 2008; 31(4):651-5.
21. Nutan, Modi M, Goel T, Das T, Malik S, Suri S, Rawat AK, Srivastava SK, Tuli R, Malhotra S, Gupta SK. Ellagic acid & gallic acid from Lagerstroemia speciosa L. inhibit HIV-1 infection through inhibition of HIV-1 protease & reverse transcriptase activity. The Indian Journal of Medical Research. 2013; 137(3):540-8.
22. Yamaguchi Y, Yamada K, Yoshikawa N, Nakamura K, Haginaka J, Kunitomo M. Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome. Life Sci . 2006; 79(26):2474-9.
23. Kunitomo M. Oxidative stress and atherosclerosis [in Japanese]. Yakugaku Zasshi . 2007; 127(12):1997-2014.
24. Aguirre MC, Delporte C, Backhouse N. Topical anti-inflammatory activity of 2 alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae. Bioorganic & Medicinal Chemistry Letters. 2006; 14(16):5673-7.
25. Takayama H, Kitajima M, Ishizuka T, Seo S. Process for producing corosolic acid. US patent 2004-866733. June 15, 2004.
26. William V. Judy A, Siva P. Hari B, Stogsdill A, Janet S. Judy A, Yousry MA, Naguib B, Richard P. Antidiabetic activity of a standardized extract (Glucosol™) from Lagerstroemia speciosa leaves in Type II diabetics: A dose-dependence study. Journal of Ethnopharmacology. 2003; 87(1):115-7.
27. Xu Y, Ge R, Du J, Xin H, Yi T, Sheng J, Wang Y, Ling C. Corosolic acid induces apoptosis through mitochondrial pathway and caspases activation in human cervix adenocarcinoma HeLa cells. Cancer Letters. 2009; 2 84:229-37.
28. Fujiwara Y, Komohara Y, Ikeda T, Takeya M. Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages. Cancer Science. 2011; 102:206-11.
29. Miura T, Ueda N, Yamada K, Fukushima M, Ishida T, Kaneko T, Matsuyama F, Seino Y.Antidiabetic effects of corosolic acid in KK-Ay diabetic mice. Biological and Pharmaceutical Bulletin. 2006; 29(3):585-7.
30. Shi L, Zhang W, Zhou YY, Zhang YN, Li JY, Hu LH, Li J. Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation. European Journal of Pharmacology. 2008; 584(1):21-9.
31. Horlad H, Fujiwara Y, Takemura K, Ohnishi K, Ikeda T, Tsukamoto H, Mizuta H, Nishimura Y, Takeya M, Komohara Y.Corosolic acid impairs tumor development and lung metastasis by inhibiting the immuno-suppressive activity of myeloid-derived suppressor cells. Molecular Nutrition and Food Research. 2013; 57:1046-54.
32. Park JB, Lee JS, Lee MS, Cha EY, Kim S, Sul JY. Corosolic acid reduces 5‑FU chemoresistance in human gastric cancer cells by activating AMPK. Molecular Medicine Reports. 2018; 18(3):2880-8.
33. Tan H, Sonam T, Shimizu K. The Potential of Triterpenoids from Loquat Leaves (Eriobotrya japonica) for Prevention and Treatment of Skin Disorder. International Journal of Molecular Sciences. 2017 May 11; 18(5). pii: E1030. doi: 10.3390/ijms18051030.
34. Jia Y, Yuan H, Shan S, Xu G, Yu J, Zhao C, Mou X. Corosolic acid inhibits the proliferation of osteosarcoma cells by inducing apoptosis. Oncology Letters. 2016; 12(5):4187-94.
35. Kim S, Cha JY, Kang HS, Lee JH, Lee JY, Park JH, Bae JH, Song DK, Im SS. Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages. BMB Reports. 2016; 49(5):276-81.
2. Jung M, Park M, Lee HC, Kang YH, Kang ES, Kim SK. Antidiabetic agents from medicinal plants. Current Medicinal Chemistry. 2006; 13(10):1203-8.
3. Washino T, Kato Y, Zeida M, Minami H, inventors. Hypoglycemic banaba (Lagerstroemia speciosa ) extracts. US patent 2005-JP7255. April 14, 2004.
4. Egawa K, Takemoto J, Kajimoto Y, Yonaha N, Miura T, Kaneko T, Nishi Y, Mitsui R, Fujita Y, Yamada Y, Seino Y. Effect of corosolic acid on postchallenge plasma glucose levels. Diabetes Research and Clinical Practice. 2006; 73(2):174-7.
5. Shi L, Zhang W, Zhou YY, Zhang YN, Li JY, Hu LH, Li J. Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation. European Journal of Pharmacology. 2008; 584(1):21-9.
6. Miura T, Itoh Y, Kaneko T, Ueda N, Ishida T, Fukushima M, Matsuyama F, Seino Y. Corosolic acid induces GLUT4 translocation in genetically type 2 diabetic mice. Biological and Pharmaceutical Bulletin. 2004; 27(7):1103-5.
7. Yamada K, Hosokawa M, Fujimoto S, Fujiwara H, Fujita Y, Harada N, Yamada C, Fukushima M, Ueda N, Kaneko T, Matsuyama F, Yamada Y, Seino Y, Inagaki N.Effect of corosolic acid on gluconeogenesis in rat liver. Diabetes Research and Clinical Practice. 2008; 80(1):48-55.
8. Klein G, Kim J, Himmeldirk K, Cao Y, Chen X. Antidiabetes and anti-obesity activity of Lagerstroemia speciosa. Evidence-Based Complement and Alternative Medicine. 2007; 4(4):401-7.
9. Hou W, Li Y, Zhang Q, Wei X, Peng A, Chen L, Wei Y. Triterpene acids isolated from Lagerstroemia speciosa leaves as α-glucosidase inhibitors. Phytotherapy research. 2009; 23(5):614-8.
10. Ahn KS, Hahm MS, Park EJ, Lee HK, Kim IH. Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent. Planta Medica. 1998; 64(5):468-70.
11. Akihisa T, Kama S, Uchiyama T. Cytotoxic activity of Perilla frutescens var. japonica leaf extract is due to high concentractions of oleanolic and ursolic acids. Journal of Natural Medicine. 2006;60(4):331-3.
12. Kim JH, Kim YH, Song GY, Kim DE, Jeong YJ, Liu KH, Chung YH, Oh S.Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of β-catenin degradation. Food and Chemical Toxicology.2014; 67:87-95.
13. Fujiwara Y, Takaishi K, Nakao J, Ikeda T, Katabuchi H, Takeya M, Komohara Y.Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling. Oncology Letters.2013; 1619-23.
14. Ku CY, Wang YR, Lin HY, Lu SC, Lin JY. Corosolic Acid Inhibits Hepatocellular Carcinoma Cell Migration by Targeting the VEGFR2/Src/FAK Pathway. PLOSone. 2015; DOI:10.1371/journal.pone.0126725.
15. Ember JA, Hugli TE. Complement factors and their receptors. Immunopharmacology. 1997; 38:3-15.
16. Thuong PT, Min BS, Jin W, Na M, Lee J, Seong R, Lee YM, Song K, Seong Y, Lee HK, Bae K, Kang SS. Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis. Biological & Pharmaceutical Bulletin. 2006;29(4):830-3.
17. Yamaguchi Y, Yamada K, Yoshikawa N, Nakamura K, Haginaka J, Kunitomo M. Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome. Life Sciences. 2006;79(26):2474-9.
18. Na M, Yang S, He L, Oh H, Kim BS, Oh WK, Kim BY, Ahn JS.Inhibition of protein tyrosine phosphatase 1B by ursane-type triterpenes isolated from Symplocos paniculata . Planta Medica. 2006; 72(3):261-3.
19. Jang DS, Lee GY, Kim J, Lee YM, Kim JM, Kim YS, Kim JS.A new pancreatic lipase inhibitor isolated from the roots of Actinidia arguta. Archives of Pharmacal Research. 2008; 31(5):666-70.
20. Yamada K, Hosokawa M, Yamada C, Watanabe R, Fujimoto S, Fujiwara H, Kunitomo M, Miura T, Kaneko T, Tsuda K, Seino Y, Inagaki N.Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice. Biological and Pharmceutical Bulletin. 2008; 31(4):651-5.
21. Nutan, Modi M, Goel T, Das T, Malik S, Suri S, Rawat AK, Srivastava SK, Tuli R, Malhotra S, Gupta SK. Ellagic acid & gallic acid from Lagerstroemia speciosa L. inhibit HIV-1 infection through inhibition of HIV-1 protease & reverse transcriptase activity. The Indian Journal of Medical Research. 2013; 137(3):540-8.
22. Yamaguchi Y, Yamada K, Yoshikawa N, Nakamura K, Haginaka J, Kunitomo M. Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome. Life Sci . 2006; 79(26):2474-9.
23. Kunitomo M. Oxidative stress and atherosclerosis [in Japanese]. Yakugaku Zasshi . 2007; 127(12):1997-2014.
24. Aguirre MC, Delporte C, Backhouse N. Topical anti-inflammatory activity of 2 alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae. Bioorganic & Medicinal Chemistry Letters. 2006; 14(16):5673-7.
25. Takayama H, Kitajima M, Ishizuka T, Seo S. Process for producing corosolic acid. US patent 2004-866733. June 15, 2004.
26. William V. Judy A, Siva P. Hari B, Stogsdill A, Janet S. Judy A, Yousry MA, Naguib B, Richard P. Antidiabetic activity of a standardized extract (Glucosol™) from Lagerstroemia speciosa leaves in Type II diabetics: A dose-dependence study. Journal of Ethnopharmacology. 2003; 87(1):115-7.
27. Xu Y, Ge R, Du J, Xin H, Yi T, Sheng J, Wang Y, Ling C. Corosolic acid induces apoptosis through mitochondrial pathway and caspases activation in human cervix adenocarcinoma HeLa cells. Cancer Letters. 2009; 2 84:229-37.
28. Fujiwara Y, Komohara Y, Ikeda T, Takeya M. Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages. Cancer Science. 2011; 102:206-11.
29. Miura T, Ueda N, Yamada K, Fukushima M, Ishida T, Kaneko T, Matsuyama F, Seino Y.Antidiabetic effects of corosolic acid in KK-Ay diabetic mice. Biological and Pharmaceutical Bulletin. 2006; 29(3):585-7.
30. Shi L, Zhang W, Zhou YY, Zhang YN, Li JY, Hu LH, Li J. Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation. European Journal of Pharmacology. 2008; 584(1):21-9.
31. Horlad H, Fujiwara Y, Takemura K, Ohnishi K, Ikeda T, Tsukamoto H, Mizuta H, Nishimura Y, Takeya M, Komohara Y.Corosolic acid impairs tumor development and lung metastasis by inhibiting the immuno-suppressive activity of myeloid-derived suppressor cells. Molecular Nutrition and Food Research. 2013; 57:1046-54.
32. Park JB, Lee JS, Lee MS, Cha EY, Kim S, Sul JY. Corosolic acid reduces 5‑FU chemoresistance in human gastric cancer cells by activating AMPK. Molecular Medicine Reports. 2018; 18(3):2880-8.
33. Tan H, Sonam T, Shimizu K. The Potential of Triterpenoids from Loquat Leaves (Eriobotrya japonica) for Prevention and Treatment of Skin Disorder. International Journal of Molecular Sciences. 2017 May 11; 18(5). pii: E1030. doi: 10.3390/ijms18051030.
34. Jia Y, Yuan H, Shan S, Xu G, Yu J, Zhao C, Mou X. Corosolic acid inhibits the proliferation of osteosarcoma cells by inducing apoptosis. Oncology Letters. 2016; 12(5):4187-94.
35. Kim S, Cha JY, Kang HS, Lee JH, Lee JY, Park JH, Bae JH, Song DK, Im SS. Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages. BMB Reports. 2016; 49(5):276-81.
Published
2019-06-15
How to Cite
Park, C., & LEE’s, J. S. (2019). Review on Corosolic Acid:Based on Various Pharmaceutical Effects. Asian Journal of Pharmaceutical Research and Development, 7(3), 104–107. https://doi.org/10.22270/ajprd.v7i3.516
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Review Articles
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