Fabrication and Characterization of Pluronic F68 and Phospholipon 90g Embedded Nanoformulation for Sertraline Delivery: An Optimized Factorial Design Approach and In Vivo Study

Authors

  • Krishna Kushwaha Lutawan Institute of Pharmacy, Sakara Jaitpura, Ghazipur, Uttar Pradesh, India-233001
  • Manoj Kumar Mishra Department of Pharmaceutics, Shambhunath Institute of Pharmacy, Jhalwa, Prayagraj- India
  • Rajat Srivastava Department of Pharmaceutics, Shambhunath Institute of Pharmacy, Jhalwa, Prayagraj-India

DOI:

https://doi.org/10.22270/ajprd.v7i3.505

Keywords:

Sertraline, 32 factorial design, physical morphology, nanostructure lipid carrier, bioavailability, in vivo study

Abstract

Objective: The objective of present work was to utilize the potential of nanostructured lipid carriers (NLCs) form improvement in bioavailability of Sertraline as antidepressant drug formulated by emulsification- solvent evaporation technique with some modification. NLC is the blend of solid lipid, liquid lipid and surfactant for encapsulation of poor water soluble actives. Design: A full 32 factorial design was utilized to study the effect of two independent parameters namely solid lipid to liquid lipid concentration and stabilizer concentration on the entrapment efficiency of the prepared NLCs. The sertraline NLC formulation was characterized with respect to particle size, polydispersity index (PDI), zeta-potential, encapsulation efficiency and physical morphology. Result: The NLC formulation had an average diameter of 96.59 nm, PDI of 0.192, zeta-potential of -39.88 mV, and encapsulation efficiency of 97%, respectively. Conclusion: The NLC formulation for sertraline encapsulation has been successfully developed and is suitable for nose to brain delivery system due to their nano-size and sta

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Author Biographies

Krishna Kushwaha, Lutawan Institute of Pharmacy, Sakara Jaitpura, Ghazipur, Uttar Pradesh, India-233001

Lutawan Institute of Pharmacy, Sakara Jaitpura, Ghazipur, Uttar Pradesh, India-233001

Manoj Kumar Mishra, Department of Pharmaceutics, Shambhunath Institute of Pharmacy, Jhalwa, Prayagraj- India

Department of Pharmaceutics, Shambhunath Institute of Pharmacy, Jhalwa, Prayagraj-, India

Rajat Srivastava, Department of Pharmaceutics, Shambhunath Institute of Pharmacy, Jhalwa, Prayagraj-India

Department of Pharmaceutics, Shambhunath Institute of Pharmacy, Jhalwa, Prayagraj- India

References

1. Bartha C, Parker C, Thomson C, Kitchen K. Centre for addiction and mental health depressive illness: A guide for people with depression and their families.1999;1-6.
2. Abrahamson DJ, Lynne M, Hornyak LM, Rehm LP. Understanding depression and effective treatment. American Psychological Association, 2010.
3. Gupta A, Aggarwal G, Singla S, Arora R. Transferosomes: A novel vesicular carrier for enhanced transdermal delivery of sertraline: Development, characterization, and performance evaluation. Scientia Pharmaceutica. 2012; 80(4):1061-1080.
4. Beloqui A, Solinís MA, Rodríguez-Gascón A, Almeida AJ, Préat V. Nanostructured lipid carriers: Promising drug delivery systems for future clinics Nanomedicine: Nanotechnology, Biology, and Medicine. 2016; 12(1): 143-161.
5. Patel KS, Solanki N, Solanki SN. Nanostructured lipid carrier- A novel drug delivery. Journal of Pharmaceutical Science and Bioscientific Research. 2015; 5(4):385-392.
6. Mishra DK, Kumar A, Raj R, Chaturvedi A. Capmul MCM based nanoemulsion for intranasal delivery of an antidepressant. Bulletin of Pharmaceutical Research. 2013; 3(1):34-39.
7. Gartziandia O, Herran E, Pedraz JL, Carro E, Igartua M, Hernandez RM. Chitosan coated nanostructured lipid carriers for brain delivery of proteins by intranasal administration. 2015; 134: 304-313.
8. Ammar HO, Ghorab MM, Mostafa DM, Ghoneim AM. Self-nano emulsifying drug delivery system for sertraline hydrochloride: design, preparation and characterization, International Journal of Pharmacy and Pharmaceutical Sciences. 2014; 6(9):589-595.
9. Rahman MA, Iqbal Z, Hussain A. Formulation optimization and in vitro characterization of sertraline loaded self-nanoemulsifying drug delivery system (SNEDDS) for oral administration. International Journal of Pharmaceutical Investigation. 2012; 42(4):191-202.
10. MacQueen G, Born L, Steiner M. The selective serotonin reuptake inhibitor sertraline: Its profile and use in psychiatric disorders. CNS Drug Reviews Vol. 7, No. 1, Neva Press, Branford, Connecticut: 2001; 7(1):1-24.
11. Alam MI, Baboota S, Ahuja A, Ali M, Ali J, Sahni JK, Bhatnagar A. Pharmacoscintigraphic evaluation of potential of lipid nanocarriers for nose-to-brain delivery of antidepressant drug. International Journal of Pharmaceutics.2014; 470(1-2):99-106.
12. Dandagi PM, Dessai GA, Gadad AP, Desai VB. Formulation and evaluation of nanostructured lipid carrier (NLC) of lornoxicam. International Journal of Pharmacy and Pharmaceutical Sciences. 2014; 6(2): 73-77.
13. Shah NV, Seth AK, Balaraman R, Aundhia CJ, Maheshwari RA, Parmar GR. Nanostructured lipid carriers for oral bioavailability enhancement of raloxifene: Design and In vivo study. Journal of Advanced Research. 2016; 7(3): 423-434.
14. Gaba B, Fazil M, Khan S, Ali A, Baboota S, Ali J. Nanostructured lipid carrier system for topical delivery of terbinafine hydrochloride. Bulletin Faculty Pharmacy Cairo University. 2015; 53(2):147-159.
15. Eskandari S, Varshosaz J, Minaiyan M, Tabbakhian M. Brain delivery of valproic acid via intranasal administration of nanostructured lipid carriers: In vivo pharmacodynamic studies using rat electroshock model. International Journal of Nanomedicine.2011; 6:363-371.
16. Patel RJ, Patel ZP. Formulation optimization and evaluation of nanostructured lipid carriers containing valsartan. International Journal of Pharmaceutical Sciences and Nanotechnology. 2013; 6(2):2077-2086.
17. Dandagi PM, Dessai GA, Gadad AP, Desai VB. Formulation and evaluation of nanostructured lipid carrier (NLC) of lornoxicam. International Journal of Pharmacy and Pharmaceutical Sciences.2014; 6(2):73-77.
18. Uner M, Karaman EF, Aydogmus Z. Solid lipid nanoparticles and nanostructured lipid carriers of loratadine for topical appliction: Physicochemical stability and drug penetration through rat skin. Tropical Journal of Pharmaceutical Research. 2014; 13(5): 653-660.
19. Sethuraman N, Shanmuganathan S, Sandhya K, Anbarasan B. Design, development and characterization of nano structured lipid carrier for topical delivery of aceclofenac. Indian Journal of Pharmaceutical Education and Research. 2018; 52(4):581-586.
20. Patil NL, Mahajan HS. Quercetin loaded nanostructured lipid carriers for nose to brain delivery: In vitro and in vivo studies. Amercan Journal of Advanced Drug Delivery. 2018; 6(1):009-020.
21. Haque S, Md S, Sahni JK, Ali J, Baboota S. Development and evaluation of brain targeted intranasal alginate nanoparticles for treatment of depression. Journal of Psychiatric Research. 2014; 48(1):1-12.
22. Moffat AC, Osselton MD, Widdop B. Clarke's analysis of drugs and poisons, Pharmaceutical Press, London (2011).

Published

2019-06-15

How to Cite

Kushwaha, K., Mishra, M. K., & Srivastava, R. (2019). Fabrication and Characterization of Pluronic F68 and Phospholipon 90g Embedded Nanoformulation for Sertraline Delivery: An Optimized Factorial Design Approach and In Vivo Study. Asian Journal of Pharmaceutical Research and Development, 7(3), 59–66. https://doi.org/10.22270/ajprd.v7i3.505