FORMULATION AND CHARACTERIZATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF SPIRONOLACTONE

Authors

  • Ankur Gupta Sri Aurobindo Institute of Pharmacy Indore, Madhya Pradesh (India)
  • Arpna Indurkhya Sri Aurobindo Institute of Pharmacy ,Indore, Madhya Pradesh (India)
  • S.C Chaturvedi Sri Aurobindo Institute of Pharmacy Indore, Madhya Pradesh (India)
  • Ajit Varma Sri Aurobindo Institute of Pharmacy Indore, Madhya Pradesh (India)

DOI:

https://doi.org/10.22270/ajprd.v7i1.462

Keywords:

Spironolactone, Bioavailability, Solubility, SEDD

Abstract

Spironolactone is aldosterone antagonist drug belonging to the category of potassium sparing diuretics administered orally that has absolute bioavailability of only 68% due to the poor aqueous solubility. The main aim of the present work was to develop a self emulsifying drug delivery system (SEDDS) to enhance the oral absorption of spironolactone. The solubility of spironolactone in various oils, surfactants, and co surfactants was determined. Pseudo ternary phase diagrams were constructed using castor oil, Tween 80, and polyethylene glycol 400, and distilled water to identify the efficient self-micro emulsion region. Prepared self emulsifying drug delivery system was further evaluated for its emulsification time, drug content, optical clarity, droplet size, zeta potential, in vitro drug release. The results showed that 96.16% drug was released from the SEDDS formulation in 3 hrs. This demonstrated an enhancement in the drug release and thereby, absorption of the drug through the membrane, this was significantly higher than that of the plain drug suspension. Thus, the above findings support that the utility of SEDDS to enhance solubility and dissolution of poorly water soluble compounds which may result in improved Therapeutic performance.

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Author Biographies

Ankur Gupta, Sri Aurobindo Institute of Pharmacy Indore, Madhya Pradesh (India)

Sri Aurobindo Institute of Pharmacy Indore-Ujjain State Highway, Near MR-10 Crossing Indore, Madhya Pradesh (India)

Arpna Indurkhya, Sri Aurobindo Institute of Pharmacy ,Indore, Madhya Pradesh (India)

Sri Aurobindo Institute of Pharmacy Indore-Ujjain State Highway, Near MR-10 Crossing Indore, 453111, Madhya Pradesh (India)

S.C Chaturvedi, Sri Aurobindo Institute of Pharmacy Indore, Madhya Pradesh (India)

Sri Aurobindo Institute of Pharmacy Indore-Ujjain State Highway, Near MR-10 Crossing Indore, 453111, Madhya Pradesh (India)

Ajit Varma, Sri Aurobindo Institute of Pharmacy Indore, Madhya Pradesh (India)

Sri Aurobindo Institute of Pharmacy Indore-Ujjain State Highway, Near MR-10 Crossing Indore, 453111, Madhya Pradesh (India)

References

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2. Borhade V, Nair H. Self emulsifying drug delivery system: A tool in solubility enhancement of poorly soluble drugs, global Journal of Pharmaceutical Sciences 2012; 2(3):1-2
3. Date A. A, Nagarsenker M. S. Design and Evaluation of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Cefpodoxime Proxetil. International Journal of Pharmacy. 2007; 329 (2): 166-72.
4. Dewan I, Gaji M, Ashraful I. In vitro study of SEDDS of poorly water soluble drug spironolactone, International Journal of Pharmaceutical Science and Research. 2012; 3(5): 1-5.
5. Dewan I, Gaji M, Ashraful I. In vitro study of SEDDS of poorly water soluble drug spironolactone, International Journal of Pharmaceutical Science and Research. 2012; 3(5): 1-5.

Published

2019-02-15

How to Cite

Gupta, A., Indurkhya, A., Chaturvedi, S., & Varma, A. (2019). FORMULATION AND CHARACTERIZATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF SPIRONOLACTONE. Asian Journal of Pharmaceutical Research and Development, 7(1), 38–40. https://doi.org/10.22270/ajprd.v7i1.462