Novel Topical Liposomal Gel of Benzoyl Peroxide And Resveratrol For Treatment Of Acne
DOI:
https://doi.org/10.22270/ajprd.v6i2.362Keywords:
liposomes,resveratrol,benzoyl peroxide,topicalAbstract
Liposomal formulations have been used in the treatment of a number of dermatological diseases . Benzoyl peroxide is the drug of choiceused for the treatment of acne but suffers from side effects such as skin redness, irritation, itching, oedema and dryness. In this research work benzoyl peroxide was encapsulated into liposomes, alongwith herbal drug resveratrol for treatment of acne . Liposomes were prepared by thin film hydration technique and evaluated for pH , particle size , zeta potential , FT -IR, XRD and TEM etc. which indicated suitable encapsulation of drugs in liposomes. Liposomal gel was prepared using different polymers and evaluated for colour, pH, drug content, homogeneity and grittiness and in vitro release studies .Suitable penetration enhancers were added to the selected preparation . The final selected formulation was evaluated further for viscosity, spreadibility ,drug release, kinetic study and stability studies .Selected liposomal gel showed prolonged release of both drugs and the product was found to be stable .Ex-vivo diffusion studies and drug deposition studies on animals was performed. Skin irritation studies on animals did not show any irritation,dryness or redness.
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1. Pierre M. B. R and Costa, I. D. S. M. ,2011,Liposomal systems as drug delivery vehicles for dermal and transdermal applications, Archives of Dermatological Research, 303( 9) 607–621.
2. Patel, S. 2006 Liposome: a versatile platform for targeted delivery of drugs Pharmainfo.net,.
3. Maghraby, G. Barry, B. W. and Williams A. C., 2008, Liposomes and skin: from drug delivery to model membranes, European Journal of Pharmaceutical Sciences, . 34, ( 4-5),. 203–222.
4. Gollnick .H.,Cunliff, W., Berson ,D. et al.2003, J. Am. Acad. Dermatol.49(,1),S1-S37.
5. Baur ,J.A., Sinclair, D.A.,2006, Therapeutic potential of resveratrol: the in vivo evidence., Nat Rev Drug Discov , 5, 493-506.
6. Baxter ,R.A. 2008; Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation. J. Cosmet. Dermatol. 7, 2-7
7. Docherty, J.J., Smith ,J.S., Fu, M.M., Stoner,T., Booth, T.,2004, Effect of topically applied resveratrol on cutaneous herpes simplex virus infections in hairless mice., Antiviral Res, 61, 19-26 .
8. Chan,M.M.,2002, Antimicrobial effect of resveratrol on dermatophytes and bacterial pathogens of the skin. BiochemPharmacol ., 63, 99-104 .
9. Kedzierski, L.,Curtis, J.M., Kaminska, M., Jodynis-Liebert, J., Murias, M.2007, In vitro antileishmanial activity of resveratrol and its hydroxylated analogues against Leishmania major promastigotes and amastigotes., Parasitol Res., 102, 91-97.
10. Singh, A.Vengurlekar,P.Rathod.S. Design,2014, Development and characterization of liposomal neem gel. International Journal of Pharma Sciences and Research, 5(04), 140-148.
11. Doaa A. Hl, Dalia ABD EL-R, Sally A. Abdel-H, Mohamed A. NabarawiEL-. 2012,Formulation and Evaluation of Fluconazole topical gel. International Journal of Pharmacy and Pharmaceutical Sciences, 4(5), 176-183.
12. Dheeraj T B, Yogeshkumar A B, Kapil R B, Venkatesh B P,Mangesh K S and Jain, D. K. 2013, In Vitro and In Vivo Evaluation of Diclofenac Sodium Gel Prepared with Cellulose Ether and Carbopol 934P, Tropical Journal of Pharmaceutical Research August 12 (4), 489-494
13. Mallesh K, Srinivas,C. Nagasree K, Diwan. P V2012 , Formulation and Evaluation of Prednisolone Proliposomal Gel for Effective Topical Pharmacotherapy. International Journal of Pharmaceutical Sciences and Drug Research, 4(1), 35-43.
14. Radhika G., Manoj K S, GulabS.Thakur, AvinashSaurabh, Study Of Formulation, Characterization And Wound Healing Potential Of Transdermal Patches Of Curcumin, Asian J Pharm Clin Res, Vol 5, Suppl 4, 2012, 225-230.
15. Meghana, G.. Narayana Reddy V. V. S , Siddhartha V T,Gunda, R et al2014, Formulation and evaluation of Tolnaftate loaded topical liposomal gel for effective skin drug delivery to treat fungal diseases, Journal of Chemical and Pharmaceutical Research, 6(10), 856-866
16. Dass,S., Padala, N. M., Lilakanta,N. and Chowdhury,P.,2010. Kinetic modeling on drug release from controlled drug delivery systems, ActaPoloniaePharmaceutica n Drug Research, . 67(3), 217-223.
17. Prakash Chandra bhatt, Sanchit Sharma, Anti Microbial effects ofPurodil Gel on acne causing Propionibacterium acnes and Staphylococcus epidermidis. International Journal of Research in Cosmetic Science, 2014, 4(1): 7-9.
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