DEVELOPMENT AND OPTIMIZATION OF IMMEDIATE RELEASE TABLET OF FEBUXOSTAT IN GOUT TREATMENT
The Formulated Immediate Release tablet based was established by wet granulation techniques. The Optimized tablet were film coated for taste masking of unpleasant taste of Febuxostat drug to improve its patient compliance. The tablets were evaluated for pharmacopoeial and non pharmacopoeial (industry specified) tests. Based on the results, formulation F4 having optimized concentration of crosscarmellose sodium was identified as better formulation among all formulations developed for immediate release tablets. F4 Decrease in binder quantity and increase in disintegrant quantity and remaining all physical parameters of tablets were found satisfactory. Flow of blend was good. Disintegration time and dissolution found comparable to the reference product. Uniformity of dosage units found satisfactory. Further optimization had done by 10 more batches using different concentration of diluents, binders, lubricant, disintegrating agent & glidant and final batches was selected. The result arrived in this work indicates the immediate release formulation of Febuxostat developed in this work was found to be equivalent to reference product, based on the in-vitro Release studies and other evaluation parameters envisaged the objectives of work.
1. Kaur H. A, Review of Processing Technologies For Pharmaceutical Tablets, International Research Journal of Pharmacy, 2012;2:20-23.
2. Bhandari N, Kumar A, Choudhary A., Choudhary R., Bala R., A Review On Immediate Release Drug Delivery System, International Research Journal of Pharmaceutical and Applied Sciences, 2014,4:78-87.
3. Sahoo P.K., Delhi Institute of Pharmaceutical Sciences and Research, 2007,New Delhi.
4. Aulton M. E., “Pharmaceutics” the science of dosage form, 1988, 2nd edition churchil llivingstone.
5. Chetan P., Granulation: Preparation, Evaluation & Control 5th Annual Garnet E. Peck Symposium, 2007.
6. Prathiba T.K., Kavitha K., Selvi A., Rupesh K., Jagdeesh S., A Review on Fast Dissolving Drug Delivery Systems- A Pioneering Drug delivery Technology, Am. J. PharmTech Res., 2013, 3:4-9.
7. Kranthi Kumar K., Srinivas L., Sai Kishore V., Naseeb Basha S., Formulation and Evaluation of Poorly Soluble Febuxostat Orodispersable Tablet, American Journal of Advanced Drug Delivery, 2014;2:12-18.
8. Joseph Praveen N., Suresh Kumar J.N., Chandan Kumar B., International Journal of Research in Pharmaceutical and Nano Sciences, 2014;3:501- 508.
9. Pande V., Karale P., Goje P., Mahanavar S., An Overview on Emerging Trends in Immediate Release Tablet Technologies, Austin Therapeutics, 2016;3:12-19.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).