DEVELOPMENT AND OPTIMIZATION OF IMMEDIATE RELEASE TABLET OF FEBUXOSTAT IN GOUT TREATMENT

  • HITESHKUMAR RANCHHODBHAI PATEL S. K. PATEL COLLEGE OF PHARMACEUTICAL EDUCATION AND RESEARCH

Abstract

The Formulated Immediate Release tablet based was established by wet granulation techniques. The Optimized tablet were film coated for taste masking of unpleasant taste of Febuxostat drug to improve its patient compliance. The tablets were evaluated for pharmacopoeial and non pharmacopoeial (industry specified) tests. Based on the results, formulation F4 having optimized concentration of crosscarmellose sodium was identified as better formulation among all formulations developed for immediate release tablets. F4 Decrease in binder quantity and increase in disintegrant quantity and remaining all physical parameters of tablets were found satisfactory. Flow of blend was good. Disintegration time and dissolution found comparable to the reference product. Uniformity of dosage units found satisfactory. Further optimization had done by 10 more batches using different concentration of diluents, binders, lubricant, disintegrating agent & glidant and final batches was selected. The result arrived in this work indicates the immediate release formulation of Febuxostat developed in this work was found to be equivalent to reference product, based on the in-vitro Release studies and other evaluation parameters envisaged the objectives of work.

Keywords: Immediate Release tablet, Gout, Febuxostat, Optimization, In-vitro release studies

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References

References:
1. Kaur H. A, Review of Processing Technologies For Pharmaceutical Tablets, International Research Journal of Pharmacy, 2012;2:20-23.
2. Bhandari N, Kumar A, Choudhary A., Choudhary R., Bala R., A Review On Immediate Release Drug Delivery System, International Research Journal of Pharmaceutical and Applied Sciences, 2014,4:78-87.
3. Sahoo P.K., Delhi Institute of Pharmaceutical Sciences and Research, 2007,New Delhi.
4. Aulton M. E., “Pharmaceutics” the science of dosage form, 1988, 2nd edition churchil llivingstone.
5. Chetan P., Granulation: Preparation, Evaluation & Control 5th Annual Garnet E. Peck Symposium, 2007.
6. Prathiba T.K., Kavitha K., Selvi A., Rupesh K., Jagdeesh S., A Review on Fast Dissolving Drug Delivery Systems- A Pioneering Drug delivery Technology, Am. J. PharmTech Res., 2013, 3:4-9.
7. Kranthi Kumar K., Srinivas L., Sai Kishore V., Naseeb Basha S., Formulation and Evaluation of Poorly Soluble Febuxostat Orodispersable Tablet, American Journal of Advanced Drug Delivery, 2014;2:12-18.
8. Joseph Praveen N., Suresh Kumar J.N., Chandan Kumar B., International Journal of Research in Pharmaceutical and Nano Sciences, 2014;3:501- 508.
9. Pande V., Karale P., Goje P., Mahanavar S., An Overview on Emerging Trends in Immediate Release Tablet Technologies, Austin Therapeutics, 2016;3:12-19.
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How to Cite
PATEL, H. (2018). DEVELOPMENT AND OPTIMIZATION OF IMMEDIATE RELEASE TABLET OF FEBUXOSTAT IN GOUT TREATMENT. Asian Journal of Pharmaceutical Research and Development, 6(1), 16-25. https://doi.org/https://doi.org/10.22270/ajprd.v6i1.355