DEVELOPMENT AND VALIDATION OF A UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF VINPOCETINE IN BULK AND TABLET DOSAGE FORM

Authors

  • Pooja Bhat Department of Quality Assurance Techniques, Sinhgad College of Pharmacy, Pune , Maharashtra, India.
  • Sugandha Mulgund Department of Quality Assurance Techniques, Sinhgad College of Pharmacy, Pune , Maharashtra, India
  • Saurabh Vora Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune, Maharashtra, India.

Keywords:

Vinpocetine, Neuroprotective, UV spectrophotometric, Validation

Abstract

Vinpocetine is a neuroprotective drug used in the treatment of various neurological disorders such as dementia, Parkinson’s disease, Alzheimer’s disease and other mental illnesses. The present work describes an accurate and precise UV spectrophotometric method for quantitation of Vinpocetine in bulk and tablet dosage forms. Methanol was used as an economical solvent and all spectrophotometric parameters were optimized. The wavelength of maximum absorption for Vinpocetine was found to be 274 nm. The analytical method was validated as per ICH (International Conference on Harmonization) guidelines. It obeyed Beer-Lambert’s law indicated by the calibration curve in the range 5-30 µg/ml. The regression equation was y= 0.030x + 0.004. The Correlation Coefficient (R2 ) was found to be 0.999. Limit of Detection and Limit of Quantitation were calculated as 0.38 µg/ml and 1.16 µg/ml respectively. The proposed method can be applied for the routine quality control studies for assay of Vinpocetine in bulk and tablet dosage forms.

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Published

2013-05-01

How to Cite

Bhat, P., Mulgund, S., & Vora, S. (2013). DEVELOPMENT AND VALIDATION OF A UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF VINPOCETINE IN BULK AND TABLET DOSAGE FORM. Asian Journal of Pharmaceutical Research and Development, 1(2), 83–87. Retrieved from https://ajprd.com/index.php/journal/article/view/35

Issue

Volume 1st Issue 3rd May-June 2013

Section

Research Articles

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