Liquisolid Technology: A Novel Concept

Authors

  • Imran Khan Department of Pharmaceutics In Shriram College of Pharmacy, Banmore, Morena (M.P.), 476444 India
  • Priyanka Arjariya Department of Pharmaceutics In Shriram College of Pharmacy, Banmore, Morena (M.P.), 476444 India
  • Chandrakant Sharma Department of Pharmaceutics In Shriram College of Pharmacy, Banmore, Morena (M.P.), 476444 India
  • Sumit Sahni Department of Pharmaceutics In Shriram College of Pharmacy, Banmore, Morena (M.P.), 476444 India
  • Garima Sharma Department of Pharmaceutics In Shriram College of Pharmacy, Banmore, Morena (M.P.), 476444 India
  • Varsha Gupta Department of Pharmaceutics In Chandigarh College of Pharmacy, Landran, Mohali (Punjab), 140307 India

Keywords:

Liquisolid, Solubility Enhancements, Liquisolid Technology, Components, Evaluation

Abstract

Most of the drugs that have been invented are BCS Class II. This technique of delivering drugs is suitable mostly for lipophilic drugs and poorly water soluble drugs and enhance the immediate or sustain release formulations. Increase in dissolution rate and in turn improvement in bioavailability is observed in case of poorly water soluble drugs. Therefore; dissolution rate enhancement is the key aspect for absorption of these drugs. Liquisolid technology is very efficient in the dissolution rate enhancement of these drugs. Moreover use of the other polymers such as Eudragit and Hydroxypropyl Methylcellulose in the Liquisolid approach can cause sustained release of drugs.Liquisolid system is evaluated by flow behavior, wettability, powder bed hydrophilicity, saturation solubility, drug content, differential scanning calorimetry, Fourier transform infra red spectroscopy, powder X-ray diffraction, scanning electron microscopy, in vitro release and in vivo evaluation. Liquisolid serve as a better technique in the controlled release formulations of poorly water soluble drugs.

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Published

2017-01-01

How to Cite

Khan, I., Arjariya, P., Sharma, C., Sahni, S., Sharma, G., & Gupta, V. (2017). Liquisolid Technology: A Novel Concept. Asian Journal of Pharmaceutical Research and Development, 5(1), 1–7. Retrieved from https://ajprd.com/index.php/journal/article/view/290

Issue

Volume 5 Issue 1st Jan-Feb 2017

Section

Review Articles

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