MULTICOMPONENT SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS QUANTITATION OF RANITIDINE HYDROCHLORIDE, DOMPERIDONE AND MAGALDRATE IN TABLETS

Authors

  • Krishnasis Chakraborty Department of Quality Assurance Al-Ameen College of Pharmacy, Opposite to Lalbagh Main Gate, Hosur road, Bangalore-27
  • Mubeen G. Department of Quality Assurance Al-Ameen College of Pharmacy, Opposite to Lalbagh Main Gate, Hosur road, Bangalore-27
  • Ritu Kimbahune Department of Quality Assurance Al-Ameen College of Pharmacy, Opposite to Lalbagh Main Gate, Hosur road, Bangalore-27
  • Lalitha N. Department of Quality Assurance Al-Ameen College of Pharmacy, Opposite to Lalbagh Main Gate, Hosur road, Bangalore-27
  • Preeti Karwa Department of Pharmaceutics2 , Al-Ameen College of Pharmacy, Opposite to Lalbagh Main Gate, Hosur road, Bangalore-27

Keywords:

Ranitidine hydrochloride (RH), Domperidone (DM), Magaldrate (MG), Multicomponent analysis

Abstract

A fast simple precise multicomponent analytical method has been proposed for simultaneous estimation of Ranitidine hydrochloride, Domperidone and Magaldrate in tablet dosage form. Multicomponent analytical method uses inbuilt software of Spectrophotometer for measuring the absorbances at various wavelength intervals, processing and storing the data. The mixed standard and sample solutions were prepared in mixture of dilute HCl and water and scanned in the range of 200-400 nm. The absorbances were measured at four different wavelengths like 220 nm, 280 nm, 340 nm and 400 nm and concentration of each analyte was self-determined by instrument. Ranitidine hydrochloride, Domperidone and Magaldrate were found to be in the range of 99.4 - 101%, 98.8 - 100.74% and 102.2 - 103.5% respectively in the tablet dosage form. The method was validated in accordance with ICH guidelines and the results were found within the limits.

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Published

2016-01-01

How to Cite

Chakraborty, K., G., M., Kimbahune, R., N., L., & Karwa, P. (2016). MULTICOMPONENT SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS QUANTITATION OF RANITIDINE HYDROCHLORIDE, DOMPERIDONE AND MAGALDRATE IN TABLETS. Asian Journal of Pharmaceutical Research and Development, 4(1), 1–04. Retrieved from https://ajprd.com/index.php/journal/article/view/272

Issue

Section

Research Articles