PROPHYLACTIC EFFECT OF HYDROALCOHOLIC EXTRACT OF COLOCASIA ESCULENTA LEAVES IN CFA AND FORMALDEHYDE INDUCED ARTHRITIC RATS

Authors

  • Kumbhar C. M. Department of Pharmacology, M.S.S. College of Pharmacy, Medha, Satara 415012, Maharastra, India.
  • S. Y. Patil Department of Pharmacology, M.S.S. College of Pharmacy, Medha, Satara 415012, Maharastra, India.
  • P. S. Yadav Department of Pharmacology, M.S.S. College of Pharmacy, Medha, Satara 415012, Maharastra, India.
  • P. H. Jadhav Department of Pharmacology, M.S.S. College of Pharmacy, Medha, Satara 415012, Maharastra, India.
  • V. B. Metkari Department of Pharmacology, M.S.S. College of Pharmacy, Medha, Satara 415012, Maharastra, India.

Keywords:

Adjuvant, Rheumatoid Arthritis, Colocasia esculenta, Diclofenac, Complete Freund’s adjuvant (CFA), Formaldehyde

Abstract

Adjuvant induced arthritis is a chronic crippling, skeleton muscular disorder having nearest approximation to human rheumatoid arthritis for which there is currently no medicine available effecting a permanent cure. Even modern drugs used for the amelioration of the symptoms, offer only temporary relief and also produce severe side effects. This work was aimed at the scientific validation of the ethno-pharmacological claim about Colocasia esculenta and its anti-arthritic property. In the present study, prophylactic antiarthritic activity of hydroalcoholic extract of Colocasia esculenta leaves is done by Complete Freund's adjuvant induced arthritis model and formaldehyde induced arthritis model. Paw volume, paw diameter and loss in body weight during arthritis condition were corrected on prophylactic treatment with hydroalcoholic extract of Colocasia esculenta leaves and Diclofenac. Serum parameters such as SGOT, SGPT and ALP were also estimated for assessing the anti- arthritic potential of hydroalcoholic extract of Colocasia esculenta leaves. The results of the current investigation concluded, hydroalcoholic extract of Colocasia esculenta leaves possess a significant anti-arthritic activity against Complete Freund's adjuvant induced arthritis and formaldehyde induced arthritis model and justifying its prophylactic role in arthritic condition. The observed antiarthritic activity may be due to the presence of phytoconstituents such as alkaloid and flavonoids.

Downloads

Download data is not yet available.

References

.

Published

2014-01-01

How to Cite

M., K. C., Patil, S. Y., Yadav, P. S., Jadhav, P. H., & Metkari, V. B. (2014). PROPHYLACTIC EFFECT OF HYDROALCOHOLIC EXTRACT OF COLOCASIA ESCULENTA LEAVES IN CFA AND FORMALDEHYDE INDUCED ARTHRITIC RATS. Asian Journal of Pharmaceutical Research and Development, 2(1), 52–59. Retrieved from https://ajprd.com/index.php/journal/article/view/254

Issue

Volume 2nd Issue 1st Jan-Feb 2014

Section

Research Articles

AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).