Inflammation: The Role of Different Mediators

Authors

  • Jyoti Chhimwal Department of Pharmacology, Kota College of Pharmacy, Kota Rajasthan
  • Anu Sharma Department of Pharmacology, Kota College of Pharmacy, Kota Rajasthan
  • Priyanka Saini Department of Pharmacology, Kota College of Pharmacy, Kota Rajasthan
  • Shamiksha Sharma Department of Pharmacology, Kota College of Pharmacy, Kota Rajasthan
  • Mohd. Shahid. Khan Department of Pharmacology, Kota College of Pharmacy, Kota Rajasthan

Keywords:

COX-2, iNOS, NF-κB, MAPK, ROS, Arachidonic Acid, Nitric Oxide

Abstract

Inflammation is a protective response for the purpose of removal of exogenous and endogenous harmful substances produced by injurious stimuli and is a part of the healing process in wounded tissues. Since proinflammatory mediators such as COX-2, iNOS, tumor necrosis factor alpha (TNF-α), interleukin IL-1 and IL-6, proteases, and oxidants produced during the typical response can cause damage to normal tissues regardless of how and where the inflammatory response is triggered, the substances involved in the inflammatory response need to be tightly regulated. If the scavenging reaction is delayed, the inflammatory response may evolve into a variety of chronic inflammatory diseases, such as atherosclerosis, rheumatoid arthritis, asthma, and neurodegenerative diseases. A vast number of molecular studies have identified several target molecules involved in inflammatory changes, and most anti-inflammatory drugs currently used to suppress the biosynthesis of the inflammatory mediators mentioned earlier.

Downloads

Download data is not yet available.

Published

2015-07-01

How to Cite

Chhimwal, J., Sharma, A., Saini, P., Sharma, S., & Khan, M. S. (2015). Inflammation: The Role of Different Mediators. Asian Journal of Pharmaceutical Research and Development, 3(4), 1–11. Retrieved from https://ajprd.com/index.php/journal/article/view/247

Issue

Volume 3rd Issue 4th Jul-Aug 2015

Section

Review Articles

AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).