A Review on Proton Pump Inhibitor for The Treatment of Peptic Ulcer

  • Priyanka Saini Department of Pharmacology, Kota College of Pharmacy, Kota, Rajasthan, India
  • Anu Sharma Department of Pharmacology, Kota College of Pharmacy, Kota, Rajasthan, India
  • Jyoti Chhimwal Department of Pharmacology, Kota College of Pharmacy, Kota, Rajasthan, India
  • Mahaveer Kabra Department of Pharmacology, Kota College of Pharmacy, Kota, Rajasthan, India
  • Sanjay Singh Department of Pharmacology, Kota College of Pharmacy, Kota, Rajasthan, India

Abstract

Ulcers are sores or open wounds that occur on the skin or along the lining of the digestive tract due to loss of tissue. Peptic ulcers are craters or open sores in the lining of the upper gastro intestinal tract. Occurs due to imbalance between defenses and aggressive factors. Proton-pump inhibitors (PPIs) are a group of drugs whose main action is a pronounced and longlasting reduction of gastric acid production. it act by irreversibly blocking the hydrogen/potassium adenosine triphosphatase enzyme system (the H + /K+ ATPase, or more commonly gastric proton pump) of the gastric parietal cells. The proton pump is the terminal stage in gastric acid secretion, being directly responsible for secreting H + ions into the gastric lumen, making it an ideal target for inhibiting acid secretion.

Keywords: Peptic ulcer, Proton-pump inhibitors, Omeprazole

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How to Cite
Saini, P., Sharma, A., Chhimwal, J., Kabra, M., & Singh, S. (2013). A Review on Proton Pump Inhibitor for The Treatment of Peptic Ulcer. Asian Journal of Pharmaceutical Research and Development, 1(6), 13-22. Retrieved from https://ajprd.com/index.php/journal/article/view/124
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Review Articles

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