FREE RADICAL SCAVENGING AND NEPHROPROTECTIVE ACTIVITY OF BENINCASA HISPIDA (THUNB) LINN. AGAINST GENTAMICIN INDUCED NEPHROTOXICITY IN RATS.

Authors

  • Zulfkar Latief Qadrie Department of Cl. Pharmacology, SKIMS, Srinagar, J&K, India
  • Shakil U Rehman Department of Cl. Pharmacology, SKIMS, Srinagar, J&K, India
  • Zahoor Wafai Department of Cl. Pharmacology, SKIMS, Srinagar, J&K, India
  • R. Anandan Department of Pharmacology, Aditya BIPER, Bangalore, India
  • Humaira Ashraf Department of Animal Nutrition, SKUAST-K, J&K, India
  • Md. Mushtaque Department of Pharmacology, Vinayaka Mission’s College of Pharmacy, Salem, India

Keywords:

Gentamicin, chemically induced toxicity, nephrotoxicity, Benincasa hispida

Abstract

The seeds of Benincasa hispida (Thunb) COGN. (Family: Cucurbitaceae) was extracted with ethanol and was used to study acute toxicity, nephroprotective effects. Gentamycin was used to induce nephrotoxicity in rats. The extract was non lethal to the rats up to the dose of 5000 mg/kg b.w. At doses of 250 and 500 mg/kg b.w, the extract significantly (P<0.05) increased the nephroprotective effect in a dose dependent manner in rats. Furthermore, the extract was studied for free radical scavenging potential to correlate its nephrprotective activity. These results indicate that ethanolic extract of Benincasa hispida possesses potent nephroprotective effect and thus pharmacologically justifying its folkloric and traditional use in the management of nephrotoxicity conditions (P<0.05) increased the nephroprotective effect in a dose dependent manner in rats. Furthermore, the extract was studied for free radical scavenging potential to correlate its nephrprotective activity. These results indicate that ethanolic extract of Benincasa hispida possesses potent nephroprotective effect and thus pharmacologically justifying its folkloric and traditional use in the management of nephrotoxicity conditions.

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Published

2013-05-01

How to Cite

Qadrie, Z. L., Rehman, S. U., Wafai, Z., Anandan, R., Ashraf, H., & Mushtaque, M. (2013). FREE RADICAL SCAVENGING AND NEPHROPROTECTIVE ACTIVITY OF BENINCASA HISPIDA (THUNB) LINN. AGAINST GENTAMICIN INDUCED NEPHROTOXICITY IN RATS. Asian Journal of Pharmaceutical Research and Development, 1(2), 41–47. Retrieved from https://ajprd.com/index.php/journal/article/view/24

Issue

Volume 1st Issue 3rd May-June 2013

Section

Research Articles

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