IDENTIFICATION OF ADVERSE REACTIONS TO ORAL ANTICOAGULANT THERAPY IN HOSPITALIZED PATIENTS: A DESCRIPTIVE STUDY

Authors

  • Santos Luciana dos Pharmacist. Clinical Pharmacy Section of Hospital de Clínicas de Porto Alegre RS, BRAZIL– Department of Drug Information Center.
  • Jacqueline K. Martinbiancho Pharmacist. Clinical Pharmacy Section of Hospital de Clínicas de Porto Alegre RS, BRAZIL– Department of Drug Information Center.
  • Paula B. Mezzalira Undergratuate Research Grant recipient, Pharmacy Service of Hospital de Clínicas de Porto Alegre - Clinical Pharmacy Section.

Keywords:

Drug utilization, Drug toxicity, Pharmacovigilance, Vitamin K

Abstract

Vitamin K is a substance found at low concentrations in the human body, where it plays important roles in coagulation and calcium retention. The objective was to identify indications for use of vitamin K in a sample of hospitalized patients. In this descriptive, case-finding study, inpatients prescribed vitamin K during their hospital stays were assessed to identify the indications for vitamin K administration (thrombocytopenia due to oral anticoagulation or other drugs, vitamin K deficiency, or dietary deficiency). Patients from the Emergency Department and neonates were excluded. Overall, 161 cases were followed. In 73.3% of cases, the indication for vitamin K use was thrombocytopenia due to vitamin K deficiency. Seven patients (4.4%) had INRs outside the target range; of these, four (57%) developed bleeding, which was identified as an ADR. In the majority of patients given vitamin K, the indication was vitamin K deficiency.

Downloads

Download data is not yet available.

Published

2014-01-01

How to Cite

dos, S. L., Martinbiancho, J. K., & Mezzalira, P. B. (2014). IDENTIFICATION OF ADVERSE REACTIONS TO ORAL ANTICOAGULANT THERAPY IN HOSPITALIZED PATIENTS: A DESCRIPTIVE STUDY. Asian Journal of Pharmaceutical Research and Development, 2(1), 26–29. Retrieved from https://ajprd.com/index.php/journal/article/view/230

Issue

Volume 2nd Issue 1st Jan-Feb 2014

Section

Research Articles

AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).