Formulation and Evaluation of Transdermal Patches of Baclofen

Authors

  • Bhagyashree S. Patil Rajarambapu College of Pharmacy, Kasegaon. Tal .Walwa, Dist. Sangli(415 404), India.
  • Tanushree Sarkar Rajarambapu College of Pharmacy, Kasegaon. Tal .Walwa, Dist. Sangli(415 404), India.
  • Tina Raju Rajarambapu College of Pharmacy, Kasegaon. Tal .Walwa, Dist. Sangli(415 404), India.
  • M. A. Bhutkar Rajarambapu College of Pharmacy, Kasegaon. Tal .Walwa, Dist. Sangli(415 404), India.
  • S. K. Mohite Rajarambapu College of Pharmacy, Kasegaon. Tal .Walwa, Dist. Sangli(415 404), India.

Keywords:

Transdermal Drug delivery, In-vitro permeation study, HPMC, EC, Baclofen

Abstract

Transdermal drug delivery systems are becoming more popular in the field of modern pharmaceutics. The present study was carried out to develop matrix type transdermal patches containing Baclofen with different ratios of HPMC (hydroxyl propyl methyl cellulose) & EC (ethyl cellulose) by solvent casting method. Propylene glycol 3% is used as plasticizer & span 80 is used as permeation enhancer. The physicochemical compatibility of the drug and the polymers studied by infrared spectroscopy suggested absence of any incompatibility. Formulated transdermal films were physically evaluated with regard to thickness, weight variation, drug content, flatness, folding endurance moisture. All prepared formulations indicated good physical stability. In-vitro permeation studies of formulations were performed by using Franz diffusion cells.It shown that drug release follows zero order and the mechanism of release is diffusion from the polymer. The results suggested no physicochemical incompatibility between the drug and the polymers. Blank films were prepared and evaluated characteristics like smoothness and flexible. Further drug loaded films were prepared and evaluated for thickness, percentage flatness, tensile strength, weight uniformity, drug content,moisture content, moisture uptake, swelling index, water vapourtransmission, skin irritation and invitro-drug permeation study.

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Published

2014-09-01

How to Cite

Patil, B. S., Sarkar, T., Raju, T., Bhutkar, M. A., & Mohite, S. K. (2014). Formulation and Evaluation of Transdermal Patches of Baclofen. Asian Journal of Pharmaceutical Research and Development, 2(5), 16–25. Retrieved from https://ajprd.com/index.php/journal/article/view/218

Issue

Volume 2nd Issue 5th Sep-Oct 2014

Section

Research Articles

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