Influence of Casting Solvent and Polymer on Permeability of Propranolol Hydrochloride through Eudragit RL-100 and Eudragit RLPO Films

Authors

  • Banavat soujanya Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101, India
  • geethanjali J Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101, India
  • Mounika D Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101, India
  • sai kishore V Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101, India

Keywords:

polymer, solvents, watervapour transmissiondrug diffusion and permeability coefficient

Abstract

In the present work, eudragitL100and eudragitRLPO films were prepared and evaluated as rate controlling membrane for transdermal drug delivery systems. Dibutyl phthalate or propylene glycol at a concentration of 15w/w of the polymer was used as a plasticizer in the preparation of eudragitL100and eudragitRLPO films. Casting on mercury surface technique was employed for preparation of eudragitL100and eudragitRLPO films. The dry films were evaluated for physical appearance, water vapour transmission, drug diffusion and permeability coefficient. Both watervapour transmissions, drug diffusion rate followed zero-order kinetics. The mechanism of drug release was governed by peppas model. The diffusion exponent of releaseprofiles (slope) has a value of1.056-1.071 (n>1), which indicates supercase цtransport diffusion. The results obtained in the present study thus indicate that the polymer and solvents used in the preparation of films have shown significant influence on thewater vapour transmission, drug diffusion and permeability of the films

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Published

2014-09-01

How to Cite

soujanya, B., J, geethanjali, D, M., & V, sai kishore. (2014). Influence of Casting Solvent and Polymer on Permeability of Propranolol Hydrochloride through Eudragit RL-100 and Eudragit RLPO Films. Asian Journal of Pharmaceutical Research and Development, 2(5), 9–15. Retrieved from https://ajprd.com/index.php/journal/article/view/217

Issue

Volume 2nd Issue 5th Sep-Oct 2014

Section

Research Articles

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