Quantitative Determination Of Ketorolac Tromethmine From Ophthalmic Eye Drop Formulation By Uv-Spectrophotometry

Authors

  • Santosh Kumar Gupta Department of Pharmaceutics, PAHER University, Udaipur (Raj.)-313003, India.
  • P. Arora Jaipur College of Pharmacy, Jaipur (Raj.)-302022, India
  • R. Yadav Assistant Registrar, Rajasthan University of Health Sciences

Keywords:

Ketorolac tromethmine, UVSpectrophotometry

Abstract

A simple, accurate and economical UV-Spectrophotometric method has been developed for routine analysis of ketorolac tromethmine (KT) in ophthalmic solution. In saline phosphate buffer (PBS) pH 7.2 and simulated tear fluid (STF)/bicarbonate ringer solution pH 7.2, Ketorolac tromethmine showed maximum absorbance at 316.0 nm. In this method Ketorolac tromethmine obeyed linearity in the concentration range of 1 - 10 μg/mL (r2 > 0.99). Proposed methods were applied for ophthalmic solution and amounts of ketorolac tromethmine estimated by this method were 99.91 ± 1, 99.46 ± 1 in phosphate buffer and in simulated tear fluid respectively. Methods were validated statistically.

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Published

2014-07-01

How to Cite

Gupta, S. K., Arora, P., & Yadav, R. (2014). Quantitative Determination Of Ketorolac Tromethmine From Ophthalmic Eye Drop Formulation By Uv-Spectrophotometry. Asian Journal of Pharmaceutical Research and Development, 2(4), 72–74. Retrieved from https://ajprd.com/index.php/journal/article/view/214

Issue

Volume 2nd Issue 4th July-Agust 2014

Section

Research Articles

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