Formulation and Evaluation of Herbal Lozenges Containing (Trachyspermumammi) for the Management of Menstrual Cramps (Dysmenorrhea)
DOI:
https://doi.org/10.22270/ajprd.v14i5.1864Abstract
This study focused on devising and assessing herbal lozenges with Ajwain (Trachyspermum ammi) for treating menstrual cramps (dysmenorrhea). The lozenges contained (Trachyspermumammi), ginger (Zingiberofficinale), clove (Syzygiumaromaticum), cinnamon (Cinnamomum verum), cardamomum (cardamom Elettaria), turmeric (Curcuma longa), jaggery(Saccharum officinarum), and menthol (Mentha arvensis), chosen for their pain-relieving, muscle-relaxing, and inflammation-reducing effects. The formulated lozenges were assessed for physicochemical properties, phytochemical components, hardness test is found to be 9.5, friability test found to be 0.63, disintegration duration found to be 15min, moisture levelsfound to be 2.22%, and PH 6.2+-0.3. The findings demonstrated satisfactory quality characteristics, strong stability, and possible effectiveness in alleviating menstrual pain.
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Bhattacharya S, MiddletoneLJ, Tsourapas A, Lee AJ, Champaneria R, Daniels JP. Hysterectomy, endometrial ablation and Mirena for heavy menstrual bleeding; a systematic Review of clinical effectiveness and cost-effectiveness analysis, Health Technol Assess, 2011; 15(19): 1-252.
A review of in vitro and in vivo studies on the efficacy of herbal medicine for primary Dysmenorrhea Kyung sun park, Kang-in park , department of Korean medicine obstetrics and Gynecology, college of Korean medicine, 2014 ,volume2014 , page no.1-11.
Patel O., Patel M., Formulation and evaluation of medicated sucrose – free herbal lozenges Of turmeric for sore throat, International Journal of Advanced Multidisciplinary Research and Studies, 2022; 2(4):610-615.
Rupali Chanda, Lavanya Nallaguntla, Formulation and evaluation of medicated lozenges for Sore throat, 2020;13(10):62-67
Vidya marwal Formulation and evaluation of herbal Lozenges the international journal, of Novel research @and development 2023, volume & ISSN: 2456-4184.
Blacovides S. Avidon 1, Baker FC. What we know about primary dysmenorrhea today: a critical review. Hum Reprod Update, 2015:21:762-78. Doi: 10.1093/humupd/dmv039.
Chen CX, Shieh C, Draucker CB, Carpenter JS. Reasons women do not seek health care for dysmenorrhea. J Clin Nurs, 2018;27:e301-8. Doi: 10.1111/joen. 13946.
Proctor M. Farquhar C. Diagnosis and managementodysmenorrhoea. BMI. 2006:332:1134-8. Doi:10.1136/bmj.332.7550.1134
Yadav A, Pande S. To Explore the Efficacy of Herbal Tea Formulation For Menstrual Pain. International Journal of Pharmaceutical Science. 2024;2(7):696-705.11 Kho KA, Shields JK. Diagnosis and Management of Primary Dysmenorrhea. JAMA. 2020 Jan 21:323(3):268-269. [PubMed]
Coco AS. Primary dysmenorrhea. Am Fam Physician. 1999 Aug.60(2):489-96.
Ylikorkala O, Dawood MY. New concepts in dysmenorrhea. Am J Obstet Gynecol. 1978 Apr 01:130(7):833-47.
Low 1, Kuo PC, Tsai CL, Liu YH, Lin MW, Chao HT, et al. Interactions of BDNF Val66Met Polymorphism and Menstrual Pain on Brain Complexity. Frontiers in Neuroscience. 2018;12826.
Low 1, Kuo PC, Tsai CL, Liu YH, Lin MW, Chao HT, et al. Interactions of BDNF Val66Met Polymorphism and Menstrual Pain on Brain Complexity. Frontiers in Neuroscience.2018:12826.
Maman M. Devi A, lyer P, Singh A, Jeyakumar P. Isolation, Identification and Antimicrobial Activity of Bioactive Compound from Saraca Asoca. International Journal of Current Pharmaceutical Research. 2015:8(1):57-61.
Madhusoodanan K. Rao Y. Cardanom (large). In: Peter K, editor. Handbook of Herbs and sees. Cambridge, UK: Woodhead Publishing: 2001, p. 134-42
Vijayan K. Madhoosdanan K. Radhakrishnan V. Ravindran P. Properties and end-uses of cardamom. In. Ravindran P,Madhusoodanan K, editors, Cardamom. London: CRC Press, 2002р. 269-83.
Parthasarathy V. Prasath D. Cardamom. In. Peter K, editor. Handbook of Herbs and Spices.Cambridge, UK: Woodland Publishing Co: 2012. P. 132-67.
Kausar T. Kausar MA, Khan S. Haque S. Azad ZRAA. Optimum additive composition to minimize fat in functional goat meat nuggets: A healthy red meat functional food. Processes. 2021,9(3).
Jafarzadeh A. Nemati M. Therapeutic potentials of ginger for treatment of multiple sclerosis: A review with emphasis on its immunomodulatory, anti-inflammatory and anti-oxidative properties. Journal of Neuroimmunology, 2018,324:54 75.
Ali BH, Blunden G. Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food and Chemical Toxicology. 2008;46(2):409-20.
Sharma PK, Singh V. Ali M. Chemical composition and antimicrobial activity of fresh thizome essential oil of Zingiber officinale Roscoe. Pharmacognosy Journal. 2016;8(3).
Jolad SD, Lantz RC, Solyom AM, Chen GJ, Bates RB, Timmermann BN. Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production. Phytochemistry, 2004;65(13):1937-54.
Marwal V. International journal of Research & development. 2023:7531-2456-4184
Godse KC. Formulation & evaluation of polyherbal Lozenges for therural pain. World Journal of Pharmaceutical and Life Sciences. 2024; 11(1):3379.
Kshirsagar S. Formulation & evaluation Herbal lozenges for flu and cold of Novel research & development. 2013;8(5):2456-4184.
Anand B. Formulation & evaluation of Herbal Lozenges containing eucalyptus oil & coleus and aromatics oil. American Journal of Pharmatech Research, 2018:12249-3387.
Bindu Rani LGP, Ram, Formulation and evaluation of herbal lozenges containing nutmeg oil.2024.doi. 104758314.
More J. Lozenges, formulation and evaluation a review. International Journal of Pharmaceutical Science and Research, 2022; 7(1), ISSN 2455-4685.
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Copyright (c) 2026 Jagdale Rahul Changdev, Bhalke Rasika Dnyandeo, Kapile Chinmay Rajendra, Vrunda Devidas Nikam, Pawar Dipali Ishwar, Shriwant Shravani Rajendra, Giri Mahendra Ashok
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