UV–Spectrophotometric Method Development and Validation of Acamprosate Calcium by Absorption Maxima Method in Bulk and Tablet Dosage Form

Authors

  • M. A. Nagras Quality Assurance Department, Sinhgad College of Pharmacy Pune, 411041, Vadgaon (Bk) Maharashtra, India,
  • K. V. Kandharkar Quality Assurance Department, Sinhgad College of Pharmacy Pune, 411041, Vadgaon (Bk) Maharashtra, India,

Keywords:

Acamprosate calcium, UV- Spectrophotometric method, Tablet dosage form, Absorption maxima method

Abstract

A simple, rapid, accurate, precise, specific and economical spectrophotometric method for estimation of Acamprosate calcium in tablet dosage form has been developed. Beer-Lambert’s law was followed in the concentration range of 0.4 – 1.4 μg/ml (r2= 0.999). LOD and LOQ were found to be 0.013914 µg/ml 0.042614 µg/ml respectively. The method was validated by determining its accuracy and precision which proved suitability of the developed method for the routine estimation of Acamprosate calcium in solid dosage form.

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Published

2014-03-01

How to Cite

Nagras, M. A., & Kandharkar, K. V. (2014). UV–Spectrophotometric Method Development and Validation of Acamprosate Calcium by Absorption Maxima Method in Bulk and Tablet Dosage Form. Asian Journal of Pharmaceutical Research and Development, 2(2), 104–111. Retrieved from https://ajprd.com/index.php/journal/article/view/179

Issue

Volume 2nd Issue 2nd March-April 2014

Section

Research Articles

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