Stimuli-Responsive Nanocarriers for Site-Specific Drug Delivery System

Authors

  • Ankita Y.Gawai
  • Pooja R. Hatwar Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon rly. Dist. Amravati (444709) Maharashtra, India
  • Dr. Ravindra L. Bakal Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon rly. Dist. Amravati (444709) Maharashtra, India
  • Krushnali N. Nehar Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon rly. Dist. Amravati (444709) Maharashtra, India
  • Pranali R. Bhujade Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon rly. Dist. Amravati (444709) Maharashtra, India

DOI:

https://doi.org/10.22270/ajprd.v13i2.1547

Abstract

Stimuli-responsive nanocarriers have emerged as a promising tool for site-specific drug delivery, offering improved therapeutic efficacy and reduced side effects. These nanocarriers can respond to various internal and external stimuli, such as pH, temperature, light, and enzymes, to release therapeutic agents in a controlled manner. The design and synthesis of different types of stimuli-responsive nanocarriers, including liposomes, polymeric nanoparticles, micelles, and hydrogels, are discussed. The applications of these nanocarriers in cancer therapy, treatment of inflammatory arthritis, gene therapy, and management of neurological diseases are also explored. The benefits and challenges of using stimuli-responsive nanocarriers for site-specific drug delivery are highlighted, and future directions for research and development are outlined. The potential of stimuli-responsive nanocarriers to revolutionize the field of medicine by providing targeted and controlled drug delivery is emphasized.

 

Downloads

Download data is not yet available.

Author Biographies

Ankita Y.Gawai

Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon rly. Dist. Amravati (444709) Maharashtra, India

Pooja R. Hatwar, Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon rly. Dist. Amravati (444709) Maharashtra, India

Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon rly. Dist. Amravati (444709) Maharashtra, India

Dr. Ravindra L. Bakal, Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon rly. Dist. Amravati (444709) Maharashtra, India

Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon rly. Dist. Amravati (444709) Maharashtra, India

Krushnali N. Nehar, Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon rly. Dist. Amravati (444709) Maharashtra, India

Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon rly. Dist. Amravati (444709) Maharashtra, India

Pranali R. Bhujade, Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon rly. Dist. Amravati (444709) Maharashtra, India

Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon rly. Dist. Amravati (444709) Maharashtra, India

References

Das S, Bharadwaj P, Rahdar A, Muhammad B, Mahmood B, Taboada P, Bungau S and George K. Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis. Polymers 2020;12: 1397. doi:10.3390/polym12061397.

Ahmadi S, Rabiee N, Bagherzadeh M, Elmi F, Fatahi Y, Farjadian F, Baheiraei N, Nasseri B, Mohammad. Stimulus-Responsive Sequential Release Systems for Drug and Gene Delivery, Nano Today. 2020; 34100914. doi:10.1016/j.nantod.2020.100914.

Shah A, Aftab S, Nisar b J, Muhammad N, Iftikhar F. Nanocarriers for targeted drug delivery. journal of Drug Delivery Science and Technology. 2021;62: 102426.

Peng Mi. Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics. Theranostics. 2020; 10(10): 4557-4588. doi: 10.7150/thno.38069

Di Chang, Yuanyuan Ma, Xiaoxuan Xu, Jinbing Xie and Shenghong Ju.Stimuli-responsive polymeric nanoplatforms for cancer therapy. Frontiers in bioengineering and biotechnology.2020;9:707319.

Municoy S, Alvarez Echazu MI, Antezana PE, Galdopórpora JM, Olivetti C, Mebert AM, Foglia ML, Tuttolomondo MV, Alvarez GS, Hardy JG, Desimone MF. Stimuli-responsive materials for tissue engineering and drug delivery. International Journal of Molecular Sciences. 2020;21(13):4724

Fathi M, Zangabad PS, Majidi S, Barar J, Erfan-Niya H, Omidi Y. Stimuli-responsive chitosan-based nanocarriers for cancer therapy. BioImpacts: BI. 2017;7(4):269.

Rahim MA, Jan N, Khan S, Shah H, Madni A, Khan A, Jabar A, Khan S, Elhissi A, Hussain Z, Aziz HC. Recent advancements in stimuli responsive drug delivery platforms for active and passive cancer targeting. Cancers. 2021;13(4):670.

Karimi M, Sahandi Zangabad P, Ghasemi A, Amiri M, Bahrami M, Malekzad H, Ghahramanzadeh Asl H, Mahdieh Z, Bozorgomid M, Ghasemi A, Rahmani Taji Boyuk MR. Temperature-responsive smart nanocarriers for delivery of therapeutic agents: applications and recent advances. ACS applied materials & interfaces. 2016 ;8(33):21107-33.doi:10.1021/acsami.6b00371.

Zhang M, Hu W, Cai C, Wu Y, Li J, Dong S. Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment. Materials Today Bio. 2022;14:100223..

Zhao X, Bai J, Yang W. Stimuli-responsive nanocarriers for therapeutic applications in cancer. Cancer biology & medicine. 2021;18(2):319-35.

Awad NS, Paul V, AlSawaftah NM, Ter Haar G, Allen TM, Pitt WG, Husseini GA. Ultrasound-responsive nanocarriers in cancer treatment: A review. ACS Pharmacology & Translational Science. 2024;4(2):589-612.

López Ruiz A, Ramirez A, McEnnis K. Single and multiple stimuli-responsive polymer particles for controlled drug delivery. Pharmaceutics.2022;14(2):421.

Alsehli M. Polymeric nanocarriers as stimuli-responsive systems for targeted tumor (cancer) therapy: Recent advances in drug delivery. Saudi Pharmaceutical Journal. 2020;28(3):255-265.

AlSawaftah NM, Awad NS, Pitt WG, Husseini GA. pH-responsive nanocarriers in cancer therapy. Polymers. 2022;14(5):936.

Zhang Q, Kuang G, Li W, Wang J, Ren H, Zhao Y. Stimuli-responsive gene delivery nanocarriers for cancer therapy. Nano-Micro Letters. 2023 ;15(1):44.

Zhang CW, Zhang JG, Yang X, Du WL, Yu ZL, Lv ZY, Mou XZ. Carbohydrates based stimulus responsive nanocarriers for cancer-targeted chemotherapy: a review of current practices. Expert Opinion on Drug Delivery. 2022;19(6):623-40.

Majumder J, Minko T. Multifunctional and stimuli-responsive nanocarriers for targeted therapeutic delivery. Expert opinion on drug delivery. 2021;18(2):205-27.

Sabir F, Zeeshan M, Laraib U, Barani M, Rahdar A, Cucchiarini M, Pandey S. DNA based and stimuli-responsive smart nanocarrier for diagnosis and treatment of cancer: applications and challenges. Cancers. 2021;13(14):3396.

Kaushik N, Borkar SB, Nandanwar SK, Panda PK, Choi EH, Kaushik NK. Nanocarrier cancer therapeutics with functional stimuli-responsive mechanisms. Journal of nanobiotechnology. 2022;20(1):152

Guimarães D, Cavaco-Paulo A, Nogueira E. Design of liposomes as drug delivery system for therapeutic applications. International journal of pharmaceutics. 2021;601:120571.

Mohammad SS, Hatwar P, Bakal R and Kohale N. A comprehensive review on Liposomes: As a novel drug delivery system. GSC Biological and Pharmaceutical Sciences, 2024, 27(01), 199–210.

Mollazadeh S, Mackiewicz M, Yazdimamaghani M. Recent advances in the redox-responsive drug delivery nanoplatforms: A chemical structure and physical property perspective. Materials Science and Engineering: C. 2021; 118:111536.

Nsairat H, Khater D, Sayed U, Odeh F, Al Bawab A, Alshaer W. Liposomes: Structure, composition, types, and clinical applications. Heliyon. 2022 ;8(5).

Sim S, Wong NK. Nanotechnology and its use in imaging and drug delivery. Biomedical reports. 2021 May;14(5):42.

Bagmar NA, Hatwar PR, Shelke PG, Bakal RL. A review on “Topical gels: an emerging drug delivery system”. GSC Biological and Pharmaceutical Sciences. 2024;28(02):285-96. DOI: 10.20959/wjpr202319-30070

Waris A, Ali A, Khan AU, Asim M, Zamel D, Fatima K, Raziq A, Khan MA, Akbar N, Baset A, Abourehab MA. Applications of various types of nanomaterials for the treatment of neurological disorders. Nanomaterials. 2022;12(13):2140.

Chatterjee S, Hui PC. Review of applications and future prospects of stimuli-responsive hydrogel based on thermo-responsive biopolymers in drug delivery systems. Polymers. 2021;13(13):2086.

Sun Y, Davis E. Nanoplatforms for targeted stimuli-responsive drug delivery: A review of platform materials and stimuli-responsive release and targeting mechanisms. Nanomaterials. 2021;11(3):746.

Kaur S, Prasad C, Balakrishnan B, Banerjee R. Trigger responsive polymeric nanocarriers for cancer therapy. Biomaterials science. 2015;3(7):955-87.

Yu W, Liu R, Zhou Y, Gao H. Size-tunable strategies for a tumor targeted drug delivery system. ACS central science. 2020;6(2):100-16.DOI: 10.1021/acscentsci.9b01139

Murugan B, Sagadevan S, Fatimah I, Oh WC, Motalib Hossain MA, Johan MR. Smart stimuli-responsive nanocarriers for the cancer therapy–nanomedicine. Nanotechnology Reviews. 2021;10(1):933-53.

Jia R, Teng L, Gao L, Su T, Fu L, Qiu Z, Bi Y. Advances in multiple stimuli-responsive drug-delivery systems for cancer therapy. International journal of nanomedicine. 2021:1525-51.

Ashrafizadeh M, Delfi M, Zarrabi A, Bigham A, Sharifi E, Rabiee N, Paiva-Santos AC, Kumar AP, Tan SC, Hushmandi K, Ren J. Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches. Journal of controlled release. 2024; 351:50-80.

Deng Z, Liu S. Inflammation-responsive delivery systems for the treatment of chronic inflammatory diseases. Drug Delivery and Translational Research. 2021; 11:1475-97.

Nag S, Mohanto S, Ahmed MG, Subramaniyan V. “Smart” stimuli-responsive biomaterials revolutionizing the theranostic landscape of inflammatory arthritis. Materials Today Chemistry. 2024; 1; 39:102178.

Yu C, Li L, Hu P, Yang Y, Wei W, Deng X, Wang L, Tay FR, Ma J. Recent advances in stimulus‐responsive nanocarriers for gene therapy. Advanced Science. 2021 Jul;8(14):2100540. Chu S, Shi X, Tian Y, Gao F. pH-responsive polymer nanomaterials for tumor therapy. Frontiers in Oncology. 2022;12:855019.doi: 10.3389/fonc.2022.855019

Ganta S, Devalapally H, Shahiwala A, Amiji M. A review of stimuli-responsive nanocarriers for drug and gene delivery. Science Direct Journal of Controlled Release 126 (2008) 187–204. doi:10.1016/j.jconrel.2007.12.017

Karimi M, Ghasemi A, Zangabad PS, Rahighi R, Basri SM, Mirshekari H, Amiri M, Pishabad ZS, Aslani A, Bozorgomid M, Ghosh D. Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems. Chemical Society Reviews. 2016;45(5):1457-501.

Chen X, Wu D, Chen Z. Biomedical applications of stimuli‐responsive nanomaterials. MedComm. 2024;5(8): e643.

Xie B, Xie H. Application of stimuli-responsive hydrogel in brain disease treatment. Frontiers in Bioengineering and Biotechnology. 2024;12:1450267.

Khan J, Rudrapal M, Bhat EA, Ali A, Alaidarous M, Alshehri B, Banwas S, Ismail R, Egbuna C. Perspective insights to bio-nanomaterials for the treatment of neurological disorders. Frontiers in Bioengineering and Biotechnology. 2021;9:724158. doi: 10.3389/fbioe.2021.724158

Published

2025-04-15

How to Cite

Ankita Y.Gawai, Pooja R. Hatwar, Dr. Ravindra L. Bakal, Krushnali N. Nehar, & Pranali R. Bhujade. (2025). Stimuli-Responsive Nanocarriers for Site-Specific Drug Delivery System. Asian Journal of Pharmaceutical Research and Development, 13(2), 100–106. https://doi.org/10.22270/ajprd.v13i2.1547