Emulgel: A Novel Topical Drug Delivery System

Authors

  • Niranjan D. Waghmare Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.
  • Kanchan A. Hiwe Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.
  • Ravindra L. Bakal Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.
  • Pooja R. Hatwar Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.
  • Nagesh G. Khansole Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.
  • Umesh S. Saware Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.

DOI:

https://doi.org/10.22270/ajprd.v13i2.1545

Abstract

Emulgel, a combination of gel and emulsion, is a relatively new and innovative topical medication delivery method with a lot of potential applications in dermatology. An O/W or W/O emulsion is created using gel formulation and specific oils based on their solubility and appropriate emulsifier.Lotions, creams, ointments, and gels are examples of topical treatments that are an essential component of dermatological therapy.Not many notable side effects are present. Emulgel is a very new and creative topical medicine delivery system that combines gel and emulsion and has several potential uses in dermatology. Using gel formulation, particular oils chosen for their solubility, and the right emulsifier, an O/W or W/O emulsion is produced.The present review discusses the method of preparation of emulgel, its permeability across the skin as well as the factors affecting absorption. The evaluation parameters and some marketed formulation also discusses.

 

Downloads

Download data is not yet available.

Author Biographies

Niranjan D. Waghmare, Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.

Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.

Kanchan A. Hiwe, Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.

Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.

Ravindra L. Bakal, Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.

Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.

Pooja R. Hatwar, Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.

Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.

Nagesh G. Khansole, Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.

Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.

Umesh S. Saware, Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.

Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi Dhamangaon Rly, Dist. Amravati (444709), Maharashtra, India.

References

Jha S, Singh P, Chouhan M,Patle B,Deheriya D, Saket N. Formulation andDevelopment of Diclofenac Topical Emulgels. Journal of Chemical Health Risks. 2024;14(3):2274-2280.

Khullar R,Kumar D,Seth N,Saini S. Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi Pharmaceutical Journal. 2012;(30):63-67.

Bagmar NA,Hatwar PR,Shelke PG and Bakal RL. A review on "Topical gels: an emerging drug delivery system”.GSC Biological and Pharmaceutical Sciences. 2024; 28(02): 285–296.

Patil RB, Akarte MA, Chaudhari MP, Wagh SK, Patil HP. Development and characteristics of topical gel containing nimesulide. GSC Biological and Pharmaceutical Sciences. 2021;15(03):295–301.

Redkar RM,Patil VS, Rukari GT. EmulgelA Tool for Topical Drug Delivery. World Journal of Pharmaceutical Research. 2019;8(4):586-597.

Banyal M, Joshi S. Emulgel an Enormous Approaches for Topical Delivery of Hydrophobic Drugs. World Journal of Pharmaceutical Research. 2020;9(13):529-550.

Prasad B, Tyagi Y, Raghrtooran N. A Review on EmulgelTopical Drug delivery system.World Journal of Pharmaceutical and Life Sciences. 2020;6(6):47-55.

Kute BS, Saudagar BR. Emulsified gel A Novel approach for delivery of hydrophobic drugsan overview. Journal of Advanced Pharmacy Education & Research. 2013;3(4):368-376.

Kandale J, Sangshetti J, Dama G,Bidkar J, Umbare R, Ghangale G. Formulation and Evaluation of Polyherbal Emulgel. International Journal of Experimental Research and Review. 2023;30:296-305.

Kushwah P, Sharma KP, Koka SS, Gupta A, Sharma R, Darwhekar NG. MicroemulgelA Novel Approach for Topical Drug Delivery. Journal of Applied Pharmaceutical Research. 2021;9:14-20.

Patil BP, Datir SK, Saudagar BR. A Review of Topical Gels as Drug Delivery System. Journal of Drug Delivery & Therapeutics. 2019;9(3):989-994.

Kumar D, Singh J, Antil M, Kumar V. EmulgelNovel Topical Drug Delivery System A Comprehensive Review. International Journal of Pharmaceutical Sciences and Research. 2016;7(12):4733-4742.

Deulker AD, kubde J, Hatwar P, Bakal R. A review on Transdermal Drug Delivery system GSC. Advance Research and Reviews. 2024;18(02):347-36.

Jabbar M,Ali KW. An overview of emulgels for topical application. Journal of Pharmaceutical Sciences. 2023;23(3):263-272.

Tyagi T,Kumar P,Singh D, Paul P, Verma G,Saxena C. Emulgel Formulations for Transdermal Drug DeliveryA Review of Recent Developments. Journal of Survey in Fisheries Sciences. 2023;10(6):107-115.

Sah KS, Badola A, Nayak KB. Emulgelmagnifying the application of topicalDrug delivery. Indian Journal of Pharmaceutical and Biological Research. 2017;5(1):25-33.

Ojha A, Ojha M, Madhav VN. Recent Advancement in EmulgelA Novel Approach for Topical Drug Delivery. International Journal of Pharmaceutics and Applied Science. 2017;6(1):17-23.

Ashara K, Soniwala M,Shah K. EmulgelA novel drug delivery system. Journal of Pakistan Association of Dermatologists. 2016;26(3):244-249.

Patel N, Chaudhary S, Chaudhary A. Emulgel Emerging as a smarter value-Added Product line Extension for Topical Preparation. Indo Global Journal of Pharmaceutical Sciences2022;12(9):92-103.

Najir S, Inamdar, Nirmal S, Landye D, Manmode P. A Review on Emulgel Drug Delivery System, International Journal of Pharmacy and Pharmaaceutical Research. 2023, 26 (4), 78-94.

Prasada NS, Mutta KS. A Review on Emulgel. Asian Journal of Pharmaceutical Research and Development. 2021;9(4):147-150.

Singh V, Singh S. Formulation and Evaluation of Aceclofenac Topical Emulgels. International Journal of Medicine and Pharmaceutical Research. 2021;5(4):151-157.

Papagari P, Vijetha A. A Review on Emulgel As novel Topical Drug Delivery system. Journal of Pharmaceutics and Nanotechnology. 2021;9(1):25-32.

Zhe Maa, Bing Zhanga, Yuqi Fanb,Meng Wanga, Dereje Kebebea, Jiawei Lia, Zhidong Liu. Traditional Chinese medicine combined with hepatic targeted drug delivery systems: A new strategy for the treatment of liver diseases. 2019;117(5):1-20.

Hardenia A, Jayronia S, Jain S. EmulgelAn Emergency Tool in Topical Drug Delivery. International Journal of Pharmaceutical Sciences and Research. 2014;5(5):1653-1660.

Yadav KS, Mishra KM,Tiwari A, Shukla A. Emulgel: A new Approach for Enhanced Topical Drug Delivery, International Journal of Current Pharmaceutical Research, 2017;9(1):15-19.

Rode RJ, Dixit RJ, Upadhye K, Bakhle S, Durge R. A comprehensive review on Emulgel A new approach for enhanced topical drug delivery. International Journal of Modern Pharmaceutical Research. 2021;5(3):222-233.

Rotake BS, Hatwar RP, Bakal LR, Kohale BN. Transdermal drug delivery system recent advancement: A Comprehensive review. 2024;28(02):059-072.

Karamkar GP, Agrawal A, Chatap KV. A Review Article Formulation of Topical Gel by GbD Approach. Advance in pharmacology and Pharmay. 2023;11(2):90-101.

Samundre P, Dangi S, Paliday T, Shende M. S. A Review on Topical Gel. International Journal of Creative Research Thoughts. 2020;8(4):3831-3954.

Patil SS, Patil AP, Shah RR. Overview on Emulgel and their marketed Formulations. Asian Journal of Research in Pharmaceutical science. 2023;13(4):330-332.

Suman D, Sangeeta, Beena S. Emulgel for topical drug delivery A novel approach. ASS Biological and Pharmaceutical sciences. 2020;11(3):104-114.

Sonawane S, Salve P, Patil M. A Emulgel Review Topical Drug Delivery System. International Journal of Clinical Research and Technology. 2020;8(10):2628-2636.

Mahali S, Harsulkar AA. A Review Article On Topical Drug Delivery System of Emulgel. International Journal of Creative Research Thoughts. 2024;12(1):343-353.

Ahmad AS, Verma S, Khan J, Sharma A. Emulgel A Revolution in topical drug delivery system. International Journal of Health Sciences. 2022;6(4):10834-10856.

Waghmare DN, Hiwe AK, Bakal LR, Hatwar RP, Barewar SS, Bhoyar PP. Transdermal drug delivery system: atool for NDDS. GSC Biological and Pharmaceutical Sciences. 2025;30(02):179-194.

Dhawas V, Dhabarde D, Patil S. Emulgel A Comprehensive Review for Novel Topical Drug Delivery system, International Journal of Recent scientific Research. 2020;11(4): 38134-38138.

Donthi RM, Munnangi RS,Krishna VK, Saha NR, Singhvi G,Dubey KS, NanoemulgelA Novel Nano carrier as Tool for Topical Drug Delivery. Pharmaceutics. 2025;15(164):1-28.

Patel S, Aundhia C, The A, Shoh N, Pandya K. Emulgel A novel approach for topical Dang delivery system. European Journal of Biochemical and Pharmaceutical Research. 2016;3(9):501-506.

Matade R, Harne S, Kale S, Ponde Y, Naik T, Lamkhade G, Doke R. Therapeutic Landscape of the natural product and emulgel in psoriasis. International Journal of Pharmaceutical Chemistry and Analysis. 2024;11(1):25-34.

Panwar AS, Gandhi S, Sharma A, Upadhya N, Bairagi Y, Gujar S, Darwhekar GN, Jain G. Emugel A Review. Asian Journal of Pharmacy and life sciences. 2011;1(3):353-343.

Amruthhai HH, Jaykumar PA, Narkhede BS. A Review on Azelatic Acid Emulgel for Acne and Hyperpigmentation. International Journal of Research in Advent Technology. 2019;7(3):1620-1630.

Nathaniel P,Sarella K, Krishna RL, Godavari P. The Expanding scope of Emulgels Formulation, Evaluation and Medical Uses. International Journal of Current Science research And Review. 2025;6(5):3030-3041.

Rajpure NP, Raghatwan UA, Pote BP. Emulgel as Topical Daug Delivery system. International Journal of Create Research Thoughts. 2023;11(5):872-882.

Mishra S, Mishra NJ, Vishwkarma DK, Alam G, Singh P. A, Maurya P, A Review on Formulation Development & Evaluations of Novel Topical Emulgel, International Journal of Pharmaceutical Science and Research. 2022;75(1):149-154.

Wang K, Hao Y, Wang Y, Chen J, Man L, Deng Y, Chen J, Lian W. Functional Hydrogels and their Application in Drug Delivery Biosensors and Tissue Engineering. International Journal of Polymer Science. 2019;1-14.

Sabalingam S, Shriwardheme M. A review on emerging Application of emulgel as topical drug delivery system. World Journal of Advance research and Review. 2022;13(01):452-463.

Harinkhede BN, Avari GJ, Mahakal N. Formulation and Evaluation of Polyheatbal Emulgel for Rheumatoid Arthritis. World Journal of Pharmaceutical Research. 2022;11(4):1074-1102.

Kuldipudi SA, Korni RD, Putta S, VVS Niharika, S Kinnera, SVVNSM Lakshmi. A Review on Emulgel: Focus on Reported Research Works of Sythetic and Health Drugs Journal of Chemical Health Risks. 2024;14(3):404-421.

Samala LM,Shridevi G. Role of Polymers as Gelling Agent in the formulation of Emulgels. Polymer Science. 2016;2(112):1-8.

Panwar SA, Upadhyay N, Bairagi M, Gajar S, Dorwhekar N. G, Jain K. D. Emulgel A Review. Asian Journal of Pharmacy and life science. 2011;1(3):333-340.

Khalil Y, Khosraghi HA, Mohammed E. Preparation and Evaluation of physical and Rheological properties of clotrimazole Emulgel. Iraqi J. Pharm Sci. 2011;20(2):19-27.

Olayemi JO, David C. Emulgel: A promising Technology for Topical Delivery of Herbal Extracts. British Journal of Pharmacy. 2023;8(1):1-10.

Basha N, Prakasam K. Emulgel containing Fluconazole- Antifungal Age International Journal of Drug Development & Research. 2011;3(4):109-125.

Bansal A, Saleem AM, Imam S, Singh S. Preparation and Evaluation of Valdese Emulgel Formulations. Biomidical & Pharmacology Journal. 2024;09(10):1351-1362.

Mahaparale PS, Gaware V. Lornoxicam Emulgel. International Journal of Pharmaceutical chemistry and Analysis. 2022;4(3):83.87.

Nayak A, Mandal KS, Ramadan M, Rath KS. Physiochemical characteristics of Diclofenac Topical Emulgel. Egyptian Journal of Chemistry. 2021;64(3):1563-1573.

Khan AB, Ahmad S, Khalid Khan M, Hosny M. L, Bukhary MD, Iqbal A, Samar S. M, Halwani A, Alissa M, Menaa F. Fabrication and Characterizations of Pharmaceutical Emulgel Co-Loaded with Naproxen-Eugenol for Improved Analgesic and Anti-Inflammatory Effects. 2022;6(108)1-17.

Nigam P, Gupta KA, Vats A. Film forming Transemulgel A Novel drug delivery System. IP International Journal of Compathensive and Advanced Pharmacology. 2020;5(3):100-104.

Baibhav J, Gurpreet S, Rana A, Saini S. Development and Characterization of clarithromycin Emulgel for Topical delivery. International Journal of Drug Development & Research. 2012;4(1):310-323.

Bonde KS, Nemade SL, Chaudhari BP, Nikam RP. Formulation and Evaluation of metronidazole Emulgel for the Topical Drug Delivery. Journal of Pharmaceutical Negative Results. 2022;13(3):10493-10509.

Kumar D, Saini RR, Kumari R. Formulation and Evaluation of Emulgel of An Antifungal Drug for Topical Drug Delivery. Journal of Pharmaceutical Negative Results. 2022;13(8):4087-4100.

Semnani MK, Saeedi M, Akbari J, Eghbali M, Babaei A, Hashemi MS, Nokhodchi A. Development of a novel nanoemulgel formulation containing cumin essential oil as skin permeation enhancer. Drug development and Transitional Research. 2022;12:455-465.

Lal KD, Kumar B,Kaushik V, Alhowyan A, Kalam A. M. Molybdenum Disulfide Nanosheet-Based Nanocomposite for the Topical Delivery of Umbelliferone Evaluation of Anti-inflammatory and Analgesic Potential,American Chemical Society Publications. 2024:1-12.

Usta YD, Teksin SZ, Demiroz TF. Evaluation of Emulgel and Nanostructured lipid carrierBased Gel formulation for Transdermal Administration of Ibuprofencharacterization mechanical Properties and Ex-vivo skin permeation. AAPS PharmSciTech. 2024;25(24):1-15.

Lakshmis S, Divya R, Rao Y. S, Kumari K, Deepthi K. Emulgel-Novel Trend in Topical Drug Delivery System. Research J. Pharm and Tech. 2021;14(5):2903-2906.

N. Krishna Yeni, P. Yashwanthi, R. Hernalatha K Padmalatha, A review on Emulgels as a Novel Approach for Topical Drug Delivery, Asian Journal of Research in Pharmaceutical Sciences. 2022:12(2):163-158.

Shrivastava A, Desai S, Jain H, Meshram B. D. Formulation and Evaluation of Fusidic Acid Emulgel. Journal of Doug Delivery and Therapeutics. 2020;10(3):169-175.

Patel MB, Kuchekur BA, Pawar S. Emulgel Approach to formulation Development A Review. Biosciences Biotechnology Research Asia. 2021;18(3):459-465.

Saini R, Kaundal A, Kumar P, Kumari S, Ashawat M. Emulgel A Novel strategy for Enhanced the Topical Day Delivery, International Jaimal for Research in Applied science & Engineering Technology. 2023;11(6):3418-3432.

Hasan S, Bhandari S, Sharma A, Garg P, EmulgelA Review. Asian Journal of Pharmaceutical Research. 2021;11(4):263-263.

Vishwakarma G, Panwar S. A, Dongle N. Emulgel A Novel Technique For Transdermal Drug Delivery. Research Journal of Topical and Cosmetic Sciences. 2023;14(1):20-28.

Gupta P, Maral A,Dubey V, Yadav S, Rajbhar S. Formulation and Assessment of a pepper Betle emulgel for Antimicrobial Application. Journal of Population Therapeutic and Clinical Pharmacology. 2023;30(11):489-497.

Amgaonkar Y, Kochar N, Umekar M. Overview of Emulgel as Emergent Topical Delivery. Journal of Pharmaceutical Research International. 2021;33(62):258-268.

Karule GV, Kubde AJ, Hatwar RP, Bakal LR, Kathole SK. Innovations in Transdermal delivery: Exploring nicotine patches, microneedle and glucose monitoring technologies. GSC Biological and Pharmaceutical Sciences. 2024;29(02):341-355.

Amalkar VS, Hatwar RP, Bakal LR, Kohale BN. Advance in gold nanoparticle-mediated drug delivery system. GSC Biological and Pharmaceutical Sciences. 2024;28(02):169-179.

Published

2025-04-15

How to Cite

Waghmare, N. D., Kanchan A. Hiwe, Ravindra L. Bakal, Pooja R. Hatwar, Nagesh G. Khansole, & Umesh S. Saware. (2025). Emulgel: A Novel Topical Drug Delivery System . Asian Journal of Pharmaceutical Research and Development, 13(2), 82–91. https://doi.org/10.22270/ajprd.v13i2.1545

Issue

Vol. 13 No. 2 (2025): Volume 13 Issue 2 March- April. 2025

Section

Review Articles

Copyright (c) 2025 Niranjan D. Waghmare, Kanchan A. Hiwe, Ravindra L. Bakal, Pooja R. Hatwar, Nagesh G. Khansole, Umesh S. Saware

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).