Statistical Forecasting Of Drug-Drug Interactions Using Medicines' Physiological Similarity
DOI:
https://doi.org/10.22270/ajprd.v13i1.1529Abstract
Taking several drugs at once is a typical practice that raises the possibility of side effects and drug interactions(DDIs). Ensuring patient safety and the effectiveness of treatment methods relies heavily on the prediction and detection of DDIs. To forecast DDIs from drug structures and/or functions, many computational approaches have been used. A computer technique for DDIs prediction based on drug functional similarity is shown here. We established the model using essential biological components such as transporters, targets, enzymes, and carriers (CTET). It We applied it to 21,189 authorized medications. DDIs were determine. We determined the DDIs by gathering all the CTETs associated with each medication and then constructing the corresponding binary vectors. molarity tests to identify DDIs. Inner product-based similarity measures (IPSMs) produced the best prediction values among the similarity approaches that were considered. Researchers looked at 2,394,766 possible drug-pair interactions in total. The program may predict more than 250,000 DDIs with unknown causes. We conclude that the present technique is a general in silico strategy for DDI identification that is both simple and rapid, and we recommend it. In the future, we want to see this suggested strategy implemented as a realistic methodology for DDI identification using pharmacological functional similarities.
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Kumari, M., Dubey, A., Agarwal, S., Kushwaha, S., & Sachan, A. K. (2023). Recent Technology and Software for GDP in the Pharmaceutical Industry. International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN), 16(5), 7004–7007. https://doi.org/10.37285/ijpsn.2023.16.5.9
Dubey, A., Ghosh, N. S.., & Singh, R.S., (2023).Effects of aqueous and ethanolic seed extract of Asparagus racemosus Linn on neurobehavioral pattern of acrylamide induced experimental Zebra fish. Research Journal of Biotechnology.18(11),81-88. https://doi.org/10.25303/1811rjbt081088.
Dubey, A., Ghosh, N. S.., & Singh, R.S., (2023).Role of Aqueous and Ethanolic Seed Extract of Asparagus racemosus on Acr- Induced Neurotoxicity in Adult Zebrafish: Emergence of Neuroprotective Results. Egyptian Journal of Aquatic Biology & Fisheries,27(6), 285-296.DOI: 10.21608/EJABF.2023.329192
Dwivedi S., Bais N., Chhabra G., Joshi D., Jadhav5 S.A., Dubey A., Chhajed M. (2024). Investigation of Antiulcer Activity of Leonotisnepetaefolia (L.) R.Br. in Pylorus ligation induced and Ethanol induced Gastric ulcer in rats. Afr.J.Bio.Sc. 6(4):446-451. doi.org/10.33472/AFJBS.6.4.2024.231-240
Kumari M., Mishra G., Shukla D., Dwivedi M., Ghosh N., Tripathi A.K., HDubey A. (2024). A Novel scientific Approach: Zebrafish as an Informative in-vivo testing platform in Physiological Investigation. Afr.J.Bio.Sc. 6(4) (2024) 231-240. doi.org/10.33472/AFJBS.6.4.2024.231-
Gautam, M. K., Panda, P. K., Dubey, A., Kumari, M., & Ghosh, N. S. (2024). Zebrafish as a Fascinating Animal Model: A Robust Platform for in vivo Screening for Biomedical Research. International Journal of Pharmaceutical Investigation, 14(3), 696–701. https://doi.org/10.5530/ijpi.14.3.80
Deshmukh, R., Verma, S., Yaduwanshi, P. S., Dubey, A., & Kumari, M. (2025). Molecular-targeted Therapy for Precision Medicine in Gastrointestinal Cancer: Advancement in Cancer Targeting Strategies. Current cancer drug targets, 10.2174/0115680096333058241114064802. Advance online publication. https://doi.org/10.2174/0115680096333058241114064802
Gupta, J. K., Singh, K., Bhatt, A., Porwal, P., Rani, R., Dubey, A., Jain, D., & Rai, S. N. (2024). Recent advances in the synthesis of antidepressant derivatives: pharmacologic insights for mood disorders. 3 Biotech, 14(11), 260. https://doi.org/10.1007/s13205-024-04104-5
Singh, K., Gupta, J. K., Shrivastava, A., Jain, D., Yadav, A. P., Dwivedi, S., Dubey, A., & Kumar, S. (2025). Exploring the Pharmacological Effects of Bioactive Peptides on Human Nervous Disorders: A Comprehensive Review. CNS & neurological disorders drug targets, 24(1), 32–46. https://doi.org/10.2174/0118715273316382240807120241
Thalluri, C., Vasam, M., Jampala, R., Alagarsamy, S., Dubey, A., Lather, A., & Hooda, T. (2024). Formulation, Development, and Optimization of Fast Dissolving Tablets Containing Tapentadol Hydrochloride. Pharmaceutical nanotechnology, 10.2174/0122117385350217241122151638. Advance online publication. https://doi.org/10.2174/0122117385350217241122151638
Batt, A., Singh, K., Gupta, J. K., Chanchal, D. K., Kumar, K., Dubey, A., Jain, D. (2024). A comprehensive review of cellular stress response pathway system of Rhizomacoptidis. Pharmacological Research - Modern Chinese Medicine, 100491. https://doi.org/10.1016/j.prmcm.2024.100491
Kumar A, Chaudhary JS, Dubey A, Pachorkar SS. Nanotechnology in Ankylosing Spondylitis: Advancements in Drug Delivery and Targeted Therapy. International Journal of Drug Delivery Technology. 2024;14(2):1162-1173.
Kumar P, Savita KK, Dubey A, Gaur SS. Unlocking Dithranol’s Potential: Advanced Drug Delivery Systems for Improved Pharmacokinetics. International Journal of Drug Delivery Technology. 2024;14(2):1174-1180.
Jitendra Singh Chaudhary, Rohit Verma, Dilip Kumar Chanchal, Miss Seema Sahu, Soumya Ranjan Mishra, Vivek Tomar, Mahima Pandey, Anubhav Dubey and Shahbaz Khan (2024) Development and optimization of extended-release tablets using biodegradable natural binders for enhanced antidiabetic therapy. Biochem. Cell. Arch. 24, 2575-2579. https:// doi.org/10.51470/bca.2024.24.2.2575
Niladry S. Ghosh, Priteesachan, Radha Pal, Anubhav Dubey, Mamta Kumari (2024). Rudraksha: A Smart Drug And A Smart Nutrients: A Review. Library Progress International, 44(2), 1030-1045.
Yamoah J, Nyarko RO, Boateng PO, Boateng EA, Dubey A. Infertility: An observational study from the work of Yamoah J (1989) to modern times. International Journal of Pharmaceutical Science and Medicine 2024; 2(2): 44-52.
Dubey A, Ghosh NS, Mishra A, Kumari M, Sahu VK. Preclinical evaluation of Asparagus racemosusseed oil extract's wound healing efficacy. International Journal of Pharmaceutical Science and Medicine 2024; 2(2): 40-43.
Niladry SG, Anubhav D and Mamta K. Preclinical Evaluation of Asparagus Racemosus Seed Oil Extract’s In Vitro Anti Salmonella Efficacy. Biodiversity Online J. 5(1). BOJ. 000603. 2024. DOI: 10.31031/BOJ.2024.05.000603
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Copyright (c) 2025 Rajesh Mishra, Manu Dwivedi, Anubhav Dubey, Richard Owusu Nyarko, Mamta Kumari, Ajay Kumar Tripathi, Ateet Srivastava
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