Development of Simple, Precise UV Spectroscopic Method for the Estimation of Escitalopram Oxalate in Bulk and Marketed Tablets
DOI:
https://doi.org/10.22270/ajprd.v11i3.1391Abstract
Two new simple and accurate solvent mediums have been presented for the quantification of Escitalopram Oxalate (ESC) in tablet dosage form. A linear relationship found in the concentration range of 1-24 µg/ml for two proposed mediums viz., phosphate buffer pH 7.4 (Medium 1) and methanol: phosphate buffer pH 7.4 [1:1](Medium 2).The goodness of fit study suggests good correlation coefficient (R2 - 0.9998 and 0.9998 for proposed mediums) shows the validity of Beer’s law with intercept response < 2% calculated by the least square method indicating functional linearity between the concentration of analyte and the absorbance. Based on standard deviation of the response and slope, the LOD values for ESC for the proposed mediums found to be 0.348±0.00238 μg/ml, 0.273±0.0014 μg/ml and LOQ values found to be 1.046±0.002458 μg/ml, 0.823±0.00065 μg/ml with % RSD values less than 2.The proposed methods were successfully applied to the determination of commercially available tablets with a high percentage of recovery, good accuracy and precision.
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Sanchez C, Reines EH, Montgomery SA. A comparative review of escitalopram, paroxetine, and sertraline: Are they all alike? Int Clin Psychopharmacol 2014; (4):185-196.
Baldwin DS, Asakura S, Koyama T, Hayano T, Hagino A, Reines E et al. Efficacy of escitalopram in the treatment of social anxiety disorder: A meta-analysis versus placebo. Eur J Neuropsychopharmacol2016; (6):1062-1069.
Bandelow B, Reitt M, Rover C, Michaelis S, Görlich Y, Wedekind D. Efficacy of treatments for anxiety disorders: a meta-analysis. IntClin Psychopharmacol2015;(4):183-192.
SuneethaA, SyamaSB. A validated UV spectrophotometric method for estimation of Escitalopram Oxalate in bulk and pharmaceutical dosage forms.Asian JResChem2010; 3(4):935-937.
ChaudhariBG, ParmarHR. Spectrophotometric method for determination of Escitalopram Oxalate from tablet formulations. IntJPharmQuality Ass2010; 2(1):9-12.
Vetrichelvan T, Arul K, Sumithra M, Umadevi B. Colorimetric method for the estimation of Escitalopram Oxalate in tablet dosage form. IndJPharmSci2010; 72(2):269-271.
KakdeRB, SatoneDD. Spectrophotometric method for simultaneous estimation of Escitalopram Oxalate and Clonazepam in tablet dosage form. IndJPharmSci2009; 71(6):702-705.
SharmaS, RajpurohitH, SonwalC, SharmaP, BhandariA. Simultaneous spectrophotometric determination of Escitalopram Oxalate and Clonazepam using multi-component mode of analysis. JPharmRes2010; 3(9):2303-2305.
SakhreliyaBD, TrivediPD, ModiDK. Development and validation of spectrophotometric methods for simultaneous estimation of Escitalopram Oxalate and Etizolam in their combined tablet dosage form. JPharmSciBiosciRes2012; 2(5):195-200.
SyamaSB. Spectroscopic method validation of liquid chromatographic method for estimation of Escitalopram Oxalate in tablet dosage forms. IntJPharmaBiosci2011; 2(1):140-146.
TapobanaS, Suddhasattya D, HimansuBS, BharatD, Dibya LM, KaushikB. RP-HPLC method for the estimation of Escitalopram in bulk and in dosage forms. IntJChemRes2011; 2(2):11-15.
RavisankarP, KrishnaSB, Santosh KVS, SrinivasaBP, DevalaRG. A novel validated RP-HPLC method for the determination of Escitalopram Oxalate in bulk and pharmaceutical tablet dosage form. IntJAdvPharmSci2013; 4(6):1162-1176.
DigheVV, PawaskarP, AdhyapakS, ShambhuN, MestryD. Development of normal phase chiral liquid chromatographic method for estimation of Escitalopram Oxalate and determination of R-citalopram enantiomer from Escitalopram Oxalate inbulk drug and tablet. JChemPharmRes2012; 4(11):4804-4809.
GandhiSV, DhavaleND, JadhavVY, SabnisSS. Spectrophotometric and Reversed‐phase High‐performance Liquid Chromatographic methods for simultaneous determination of Escitalopram Oxalate and Clonazepam in combined tablet dosage form. JAssoOffAnalChemInter2008; 91(1):33-38.
ChusenaNB, DevalaRG, PasupuletiU. Development and validation of an RP-HPLC method for the simultaneous determination of Escitalopram Oxalate and Clonazepam in bulk and its pharmaceutical formulations. IntCurPharmJ2012; 1(8): 193-198.
ChakoleRD, ChardeMS, BhavsarN, MaratheRP. Simultaneous estimation of Escitalopram and Clonazepam by RP-HPLC in pharmaceutical formulation. IntJPhytopharm2012; 2(1):25-29.
KakdeRB, SatoneDD, GadapayaleKK, KakdeMG. Stability indicating RP-HPLC method for the simultaneous determination of Escitalopram Oxalate and Clonazepam. JChromaSci2013; 51:490-495.
PatelVB, DaveJB, PatelCN. RP-HPLC method for simultaneous estimation of Escitalopram Oxalate and Etizolam in bulk and tablet dosage form. AmeJPharmTech Res2012; 2(3):1053-1061.
MondalP, SanthoshB, SatlaSR, RaparlaR. A new validated simultaneous RP- RP-HPLC method for estimation of Escitalopram Oxalate and Etizolam in bulk and table dosage form. Der Pharma Chemica2013; 5(3):26-32.
SuneethaA, Muthuprasanna P. Development and validation of HPTLC method for the estimation of Escitalopram Oxalate in bulk and pharmaceutical dosage form. IntJPharmaBio Sci2013; 4(2):504-510.
MahadikMV, DhaneshwarSR, KulkarniMJ. Application of stability indicating HPTLC method for quantitative determination of Escitalopram Oxalate in pharmaceutical dosage form. EurJAnalChem2007; 2(2):101-117.
KakdeRB, SatoneD, BawaneN. HPTLC method for simultaneous analysis of Escitalopram Oxalate and Clonazepam in pharmaceutical preparations. JPlanChrom2009; 22(6):417-420.
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