Development and Validation of UV Spectroscopic Method for the Quantification of Lamotrigine in Bulk and Marketed Formulations

Authors

  • Madhusri Chagi Department of Pharmaceutical chemistry, V.L. College of Pharmacy, Raichur, Karnataka
  • Neeladri Srinivasulu Department of Pharmaceutical chemistry, V.L. College of Pharmacy, Raichur, Karnataka
  • Yegnoor Anand Kumar Department of Pharmaceutical chemistry, V.L. College of Pharmacy, Raichur, Karnataka
  • Pooja Polkal Department of Pharmaceutics, V.L. College of Pharmacy, Raichur, Karnataka
  • Keerthana Shetty Department of Pharmaceutics, V.L. College of Pharmacy, Raichur, Karnataka

DOI:

https://doi.org/10.22270/ajprd.v11i3.1388

Abstract

Two Simple and precise UV spectroscopic methods were developed for the estimation of lamotrigine in bulk and marketed tablets. The methods developed by using two solvent systems viz., Methanol: Distilled water (1:1) and Acetonitrile: 0.1N HCl (1:1) were validated as per ICH guidelines. The two proposed solvent systems validated for linearity, accuracy, precision, robustness, ruggedness and solution stability. The percent recovery in the marketed tablet formulationswere found to be good agreement with the label claim. The methods validated statistically and the results suggest these methods can employed for the routine analysis of lamotrigine in bulk and marketed tablet formulations.

 

 

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Author Biographies

Madhusri Chagi, Department of Pharmaceutical chemistry, V.L. College of Pharmacy, Raichur, Karnataka

Department of Pharmaceutical chemistry, V.L. College of Pharmacy, Raichur, Karnataka

Neeladri Srinivasulu, Department of Pharmaceutical chemistry, V.L. College of Pharmacy, Raichur, Karnataka

Department of Pharmaceutical chemistry, V.L. College of Pharmacy, Raichur, Karnataka

Yegnoor Anand Kumar, Department of Pharmaceutical chemistry, V.L. College of Pharmacy, Raichur, Karnataka

Department of Pharmaceutical chemistry, V.L. College of Pharmacy, Raichur, Karnataka

Pooja Polkal, Department of Pharmaceutics, V.L. College of Pharmacy, Raichur, Karnataka

Department of Pharmaceutics, V.L. College of Pharmacy, Raichur, Karnataka

Keerthana Shetty, Department of Pharmaceutics, V.L. College of Pharmacy, Raichur, Karnataka

Department of Pharmaceutics, V.L. College of Pharmacy, Raichur, Karnataka

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Published

2024-06-15

How to Cite

Chagi, M., Srinivasulu, N., Anand Kumar, Y., Polkal, P., & Shetty, K. (2024). Development and Validation of UV Spectroscopic Method for the Quantification of Lamotrigine in Bulk and Marketed Formulations. Asian Journal of Pharmaceutical Research and Development, 12(3), 16–22. https://doi.org/10.22270/ajprd.v11i3.1388