EVALUATION OF THE EFFECT OF ACHYRANTHES ASPERA LINN. (AMARANTHACEAE) IN EXPERIMENTALLY INDUCED INFLAMMATORY BOWEL DISEASE IN RATS.

Authors

  • Pratik kumar A. Bhatt I.K. Patel College of Pharmaceutical Education & Research, Himatnagar, Gujarat, India.
  • Tejal R Gandhi Anand Pharmacy Colleges, Anand, Gujarat, India.
  • Praful Patel Research Scholar, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan.
  • Eeknath G. Patel Research Scholar, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan.
  • Upama N. Trivedi Shivam Pharmaceutical Studies & Research Centre,Valasan, Gujarat, India

Keywords:

IBD, NFκB, DNBS, MeAa

Abstract

To Evaluation of the Effect of Achyranthes Aspera Linn. (Amaranthaceae) In Experimentally Induced Inflammatory Bowel Disease In Rats. Healthy S.D rats (200-250gm, 12-14 weeks, either sex) were randomly allocated to 6 groups (n=6): Animals of Group I, Group-IV, Group-V & Group-VI were given water, 5-ASA (100mg/kg), MeAa (200mg/kg) & MeAa (400mg/kg) respectively once a day orally for 18 days. On 11th day of the study, Colitis was induced by DNBS (120mg/kg in 50% ethanol) in animals of Group-III-VI, on same day Group II received 50% ethanol (1.6ml/kg) intracolonically. On 18th day, the animals were weighed and anaesthetized with chloroform and sacrificed for Physical, histological, Biological, as well as Histopathological parameters. Methanolic extract of drug Achyranthes Aspera Linn.was previously proved for its effect as anti inflammatory, anti microbial, anti-oxidant as well as drug was reported to contain three major constituent which was also proven their activity against NFκB, a main causative activator found in IBD. DNBS Model control animals showed significantly induce as well as increase the severity of Chronic inflammation of IBD, while Pretreatment with 5- ASA, MeAa significantly reversed these changes induced by DNBS and proving their activity against IBD. Thus Methanolic extract of Achyranthes Aspera Linn. Significantly reduce the severity of the IBD induced by DNBS in rats and the protective activity might be attributed to anti-inflammatory and anti-oxidant activities of drugs as well as they might be act on NFκB activity.

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Published

2013-09-01

How to Cite

Bhatt, P. kumar A., Gandhi, T. R., Patel, P., Patel, E. G., & Trivedi, U. N. (2013). EVALUATION OF THE EFFECT OF ACHYRANTHES ASPERA LINN. (AMARANTHACEAE) IN EXPERIMENTALLY INDUCED INFLAMMATORY BOWEL DISEASE IN RATS. Asian Journal of Pharmaceutical Research and Development, 1(5), 77–88. Retrieved from https://ajprd.com/index.php/journal/article/view/138

Issue

Volume 1st Issue 5th Sep-Oct 2013

Section

Research Articles

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