Review on Needle Free Injection Technology
DOI:
https://doi.org/10.22270/ajprd.v11i3.1253Keywords:
Needle Free Injections, Vaccination, Pain free Injections,Abstract
Introduction: Needle-free injection technology (NFIT), its advantages, and the different devices and variants available. It highlights the potential of NFIT for painless and effective drug delivery and its use in mass vaccination campaigns.
Methods: The primary factors that need to be considered to provide a stable, safe, and effective dose by NFIT. It also explains the classification of NFIT devices based on their working, type of load, mechanism of drug delivery, and site of delivery.
Results: The additional benefit of NFIT technology, which is the ability to administer highly viscous medicated formulations that cannot be administered by conventional needle and syringe systems. It also highlights some of the commercially available variants of NFIT devices, such as Bioject®, ZetaJetTM, and Vitajet.
Conclusion: The advantages and potential of NFIT for painless and effective drug delivery, particularly in mass vaccination campaigns and the developing world. It emphasizes the need for further research and development in this field to improve the stability, safety, and efficacy of NFIT devices.
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References
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2. Madan Mohan. Gupta, Vinesh Kumar, Pawan Kumar Basniwal, “Needle Free Injection: An Alternate Approach of Injection, The pharma review (February - March, 2008).” Available from: URL: http://www.kppub.com/articles/needle-freeinjection-015/needle-free-injection.html
3. ChandanMohanty, Needle Free Drug Delivery Systems: A Review, International Journal of Pharmaceutics.,2011; 3(7): 7-15.
4. Trimzi, M.A. and Ham, Y.-B. (2021) A needle-free jet injection system for controlled release and repeated biopharmaceutical delivery, MDPI. Multidisciplinary Digital Publishing Institute. Available at: https://www.mdpi.com/1999-4923/13/11/1770
5. Evans A. Intra-dermal vaccination series. Part 2.Original engineering solution. Pig Progress. 2006; 22:30.
6. Aguiar JC, Hedstrom RC, Rogers WO, Charoenvit Y, Sacci JB, Lanar DE, Majam VF, Stout RR, Hoffman SL. Enhancement of the immune response in rabbits to a malaria DNA vaccine by immunization with a needle-free jet device. Vaccine. 2001, 20:275-280.
7. Anwer K, Earle KA, Shi M, Wang J, Mumper RJ, Proctor B, Jansa K, Ledebur HC, Davis S, Eaglstein W, Rolland AP. Synergistic effect of formulated plasmid and needle-free injection for genetic vaccines. Pharm. Res. 1999, 16:889-895
8. Kale TR, Momin M. Needle free injection technology - An overview. Inov Pharm. 2014;5(1): Article 148. http://pubs.lib.umn.edu/ innovations/vol5/iss1/10
9. Chandan M, Chandana P, Mannavathy D, Srikanth D, Rahila T. Needle-free drug delivery systems: a review. Int. J. Pharma. Res. Dev. 2011; 3:8-9.
10. Mitragotri S. Current status and future prospects of needle-free liquid jet injectors. Nat. Rev. Drug Discov. 2006; 5:543-548.
11. Jackson LA, Austin G, Chen RT, Stout R, DeStefano F, Gorse GJ, Newman FK, Yu O and Weniger BG. Safety and immunogenicity of varying dosages of trivalent inactivated influenza vaccine administered by needle-freejet injectors, Vaccine. 2001; 19:4703– 470.
12. Bakshi P, Roy S, Sadhukhan S, Maiti S. Painless Microneedles for Intradermal delivery of Vaccines; J. Adv. Pharm. Edu. Res. 2014: 4(2): 158-164.
13. Reis EC, Jacobson RM, Tarbell S and Weniger BG. Taking the sting out of shots:control of vaccinationassociated pain and adverse reactions. Pediatr. Ann. 1998; 27:375-386.
14. TejaswiR.Kale, MuniraMomin, Needle Free Injection Technology - An Overview, Journal of Pharmaceutical Innovation., 2014; 5(1):
15. M. Sunitha Reddy, M. Ranjith Kumar, K.Sanjay Kumar, Anil Goli, P.Santhosh Kumar, Review On Needle Free Drug Delivery Systems, International Journal of Life Sciences, 2011; 1 (2): 76-82.
16. Gupta AK, Gupta M. Vaccine adjuvants and delivery systems. J Pharm Sci. 2020 Jan;109(1):1-22. doi: 10.1016/j.xphs.2019.08.051.
17. Mistilis MJ, Bommarius AS, Prausnitz MR. Development of a thermostable microneedle patch for influenza vaccination. J Pharm Sci. 2018 Jan;107(1):39-46. doi: 10.1016/j.xphs.2017.07.037.
18. Al-Zahrani SM, Alomary MN, Elsayed M. Needle-free injection systems: Recent advances and applications. Int J Pharm Sci Res. 2020 Oct;11(10):4709-4724. doi: 10.13040/IJPSR.0975-8232.11(10).4709-24.
19. Cui Z, Mumper RJ. Microparticles and nanoparticles as delivery systems for DNA vaccines. Crit Rev Ther Drug Carrier Syst. 2002;19(2):103-128. doi: 10.1615/CritRevTherDrugCarrierSyst.v19.i2.20.
20. de la Fuente M, Csaba N, Garcia-Fuentes M, Alonso MJ. Nanoparticles as protein and gene carriers to mucosal surfaces. Nanomedicine. 2008 Dec;3(6):845-857. doi: 10.2217/17435889.3.6.845.
21. Prausnitz MR, Bose VG, Alarcon JB, Mizrahi RA, Langer R, Weaver JC. Microneedles for drug and vaccine delivery. Advanced Drug Delivery Reviews. 2021 Mar;170:1-18. doi: 10.1016/j.addr.2020.113813.
22. Arora, Anubhav, Mark R. Prausnitz, and Samir Mitragotri. Micro-scale devices for transdermal drug delivery, International Journal of Pharmaceutics 2008; 364(2):227-236.
23. Schramm J, Mitragotri S. Transdermal drug delivery by jet injectors: Energetic of jet formation and penetration. Pharm Res 2002; 19: 1673-9.
24. Attarde, J. K., et al. Needleless Injection System: An Overview. Pharmaceutical Research 2017; 7(4):
25. Jamin A, Gorin S, Le Potier MF, Simon GK. Characterization of conventional and plasmacytoid dendritic cells in swine secondary lymphoid organs and blood. Vet. Immunol. Immunopathol. 2006, 114:224-237.
26. SmitaKolhe, SnehaSontakke, “A Review on needle free drug delivery system, International journal of current pharmaceutical research”, Vol 5, Issue 2, 2013, ISSN- 0975-7066
27. Jamin A, Gorin S, Le Potier MF, Simon GK. Characterization of conventional and plasmacytoid dendritic cells in swine secondary lymphoid organs and blood. Vet. Immunol. Immunopathol. 2006, 114:224-237.
28. Attarde, J. K., et al. Needleless Injection System: An Overview. Pharmaceutical Research 2017; 7(4):
29. C. K. Sahoo, et al, A New Sight in Needle Free Injections, International Journal of Universal Pharmacy and Bio Sciences, 2017;6(1): 97-109.
30. VermaMayak, Khan Shahid, et al, Needle Free Drug Delivery System: A Review, World Journal of Pharmacy and Pharmaceutical Science, 2016; 5(4):817-832.
31. Ekwueme DU, Weniger BG, Chen RT. Model-based estimates of risks of disease transmission and economic costs of seven injection devices in subSaharan Africa. Bull World Health Organ. 2002, 80: 859-870.
32. Romani N, Clausen BE, Stoitzner P. Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev. 2010, 234: 120-141.
33. Vien NC, Feroldi E, Lang J. Long-term anti-rabies antibody persistence following intramuscular or lowdose intradermal vaccination of young Vietnamese children. Trans. R. Soc. Trop. Med. Hyg. 2008, 102: 294-296.
34. Reddy MS, Kumar MR, Kumar S, Goli A, Kumar S. Review on Needle free drug delivery systems, Int. J. Rev. Life Sc.. 2011, 1(2), 76-82.
35. Khan, A., Siddiqui, A. A., Haroon, M., Rehman, N., Afzal, M. S., & Ali, A. (2020). Needle-free insulin delivery: An overview. Journal of Pharmaceutical Investigation, 50(6), 641-653. doi: 10.1007/s40005-020-00492-8
36. Tran, T. T., Tran, P. H. L., & Tran, T. H. (2019). Pain management with needle-free injection technology. Pain Management, 9(5), 509-516. doi: 10.2217/pmt-2018-0068
37. Eifan, A. O., & Durham, S. R. (2016). Pathogenesis, prevention, and treatment of allergic disease: The basics. Allergy, 71(7), 841-855. doi: 10.1111/all.12823
38. Sawant, D. V., Vaze, O. S., & Parikh, A. R. (2021). A review on needle-free drug delivery systems for cancer therapy. Current Drug Delivery, 18(5), 465-479. doi: 10.2174/1567201818666190522102736
39. Korkmaz, E., Friedrich, E. E., & Ramadan, G. (2020). Needle-free injection systems for non-sterile pharmaceuticals: A review of technical considerations and regulatory requirements. Drug Delivery and Translational Research, 10(1), 18-36. doi: 10.1007/s13346-019-00698-3
40. Ginsberg, B. H., Kozlovski, P., Brown, R. B., & Dungan, K. M. (2019). Painless blood glucose monitoring using a needle-free device. Journal of Diabetes Science and Technology, 13(6), 1087-1091. doi: 10.1177/1932296819867053
41. Chen, S., Hu, Z., Yang, J., Tang, W., & Peng, Z. (2018). Needle-free injection of gonadotropin-releasing hormone agonist for in vitro fertilization: A systematic review and meta-analysis. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 225, 59-67. doi: 10.1016/j.ejogrb.2018.04.037
42. Wang, Q., Jiang, T., Lin, F., & Zhang, C. (2021). Application of microneedles for drug delivery systems: a review. Journal of Materials Science, 56(12), 7109-7132.
43. ChandanMohanty, Needle Free Drug Delivery Systems: A Review, International Journal of Pharmaceutics.,2011; 3(7): 7-15.
44. Vishnu P, Sandhya M., et al, Needle free Injection Technology: A Review, International Journal of Pharmacy, 2012; 2(1): 148- 155.
45. RapoluBharath Kumar, “Needle free injection systems, The pharma innovation”, Vol. 1 No. 9, 2012, ISSN: 2277- 7695
46. Brodell RT, Bredle DL. The treatment of palmar and plantar warts using natural alpha interferon and a needleless injector. Dermatol. Surg.1995, 21, 213–18.
47. Al-Kaf A. A Review on Needle Free Injections. Universal Journal of Pharmaceutical Research. 2017; 2(5). Doi: 10.22270/Ujpr.V2i2.Rw1.
Published
2023-06-15
How to Cite
Narwade, P., Bora, V., Mhaske, P., Sheikh, A., & Biyani, K. (2023). Review on Needle Free Injection Technology. Asian Journal of Pharmaceutical Research and Development, 11(3), 52–58. https://doi.org/10.22270/ajprd.v11i3.1253
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Section
Review Articles
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