Review of the Potential of Kamandrah (Croton Tiglium L.) As A Medicinal Plant


  • Fitri Kurniasari Faculty of Pharmacy, Universitas Setia Budi, Surakarta, Indonesia, 57127
  • Jena Hayu Widyasti Faculty of Pharmacy, Universitas Setia Budi, Surakarta, Indonesia, 57127




Herbal plants are widely used to cure various diseases. Research from the Euphorbiaceae family shows activity against cancer and tumors. Croton is a member of the Euphorbiaceae family which has wide uses in the field of medicine. The Croton genus consists of various species including Croton lechleri, Croton palanostigma, Croton dracoides, and Croton tiglium with various useful secondary metabolite contents. The plant Croton tiglium L is a medicinal plant originating from China, South Asia, and India. The seeds, leaves, bark and roots of C.tiglium can relieve various diseases, including: antifungal, anti-inflammatory, anticonvulsant, wound healing, antitumor activity. The main compound content of Croton tiglium is alkaloids, flavonoids and diterpenes. The literature review aims to explore C tiglium plants based on morphological characteristics, therapeutic uses, pharmacological actions and activities and plant compound content.

The research method used was to collect and analyze the selected literature electronically with the keywords "Croton tiglium L", "Chemical constituent", "isolation", "Pharmacological action", and "Therapeutic use". Selected literature included international and national journals that had been published on several sites, such as NCBI, Elsevier, and Pubmed, and others. Selected literature in the form of journals consisting evidence and information on chemical content and pharmacological activity.



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Author Biographies

Fitri Kurniasari, Faculty of Pharmacy, Universitas Setia Budi, Surakarta, Indonesia, 57127

Faculty of Pharmacy, Universitas Setia Budi, Surakarta, Indonesia, 57127

Jena Hayu Widyasti, Faculty of Pharmacy, Universitas Setia Budi, Surakarta, Indonesia, 57127

Faculty of Pharmacy, Universitas Setia Budi, Surakarta, Indonesia, 57127


1. Banerjee, K. K., & Sen’, A. (n.d.). (1981) .Purification and Properties of a Lectin from the Seeds of Croton tiglum with Hemolytic Activity toward Rabbit Red Cells. Archives of Viochemistry and Biophysic. 1981; 212 (2): 740-753.
2. Bodas, K., Gawas, S.,Shende, V.,Satpute K. In Vitro Evaluation Anthelmintic Activity of Croton tiglium seed extract. Journal of Global Trends in Pharmaceutical Sciences, 2014; 5(4): 2052 -2054.
3. Bu, W., Shi, Y. N., Yan, Y. M., Lu, Q., Liu, G. M., Li, Y., & Cheng, Y. X. Norsesquiterpenoids from the leaves of Croton tiglium. Natural Products and Bioprospecting, 2012; 1(3):134–137.
4. Cairnes, D. A., Mirvish, S. 8, Wallcave, L., Nagel, D. L., & Smith, J. W. A RAPID METHOD FOR ISOLATING PHORBOL FROM CROTON OIL. In Cancer Letters, 1981; 14(1981) ; 1-6
5. Deepak PG, Sung HP, Hyun JIS, Gyun JS. (2020). Neuroprotective and Antineuro Inflamatory Effect of a Poisoneus Plant Croton tiglium Ekstract. J.Toxins, 2020; 261 (12):1-14
6. Du, Q., Zhao, Y., Liu, H., Tang, C., Zhang, M., Ke, C., & Ye, Y. Isolation and Structure Characterization of Cytotoxic Phorbol Esters from the Seeds of Croton tiglium. Planta Medica, 2017; 83(17): 1361–1367
7. El-Mekkawy, S., Meselhy, M. R., Nakamura, N., Hattori, M., Kawahata, T., & Otake, T. (n.d.). Anti-HIV-1 phorbol esters from the seeds of Croton tiglium. Phytochemistry, 1999; 53 (2000): 457-464
8. Han C, Yu LK,Wen JL, Hui Y, Shao H. Antidermatophytic Activity of Ethanolic Extract from Croton tiglium. BioMed Research International. 2016: 1-6
9. Heyne. Tumbuhan Berguna di Indonesia. Badan Litbang Kehutanan. Jakarta; 1987
10. Hu, J., Gao, W. Y., Gao, Y., Ling, N. S., Huang, L. Q., & Liu, C. X. M3 muscarinic receptor- and Ca2+ influx-mediated muscle contractions induced by croton oil in isolated rabbit jejunum. Journal of Ethnopharmacology, 2010; 129(3): 377–380.
11. Jang W S, Jyoti M A, Kim S. In Vitro Activity of Diterpenoid from the Vietnamese Medicinal Plant Croton tokinensis. J.Nat Med, 2016; 70: 127-132.
12. J.-C. Tsai, S. Tsai, and W.-C. Chang, Effect of ethanol extracts of three Chinese medicinal plants with anti-diarrheal properties on ion transport of the rat intestinal epithelia. Journal of Pharmacological Sciences, 2004; 94(1): 60–66
13. Kim, J. H., Lun Lee, S., Han, Y. B., Moon, J. J., & Kim, J. B. Isolation of Isoguanosine from Croton tiglium and Its Antitumor Activity. In Arch. Pharm. Res, 1994; 27 (2)
14. Kim, M. S., Kim, H. R., So, H. S., Lee, Y. R., Moon, H. C., Ryu, D. G., Yang, S. H., Lee, G. S., Song, J. H., & Kwon, K. B. Crotonis fructus and its constituent, croton oil, stimulate lipolysis in op9 adipocytes. Evidence-Based Complementary and Alternative Medicine, 2014; 2014: 1-6
15. Liebich, ¨ H M, Lehmann, R., Stefano, C. di, Haring, H. U., Kim, J. H., & Kim, K. R. (1998). Analysis of traditional Chinese anticancer drugs by capillary. In Journal of Chromatography A , 1998; 795(1998) : 388-393
16. Lima G S, Castro, Pinto D B, Machado G C, Maciel M A. Antileishmanial Activity and Trypanothione Reductase Effects of Terpenes from the Amazonian Species Croton cajucara benth. Phytomedicine, 2015; 22: 1133-1137
17. Lin, H. C., Kuo, Y. L., Lee, W. J., Yap, H. Y., & Wang, S. H. Antidermatophytic Activity of Ethanolic Extract from Croton tiglium. BioMed Research International, 2016; 2016: 1-6
18. Liu Z, Gao W, Zhang J, Hu J. Antinociceptive and Smooth Muscle Relaxant Activity of Croton tiglium Seed; An In Vitro and In Vivo Study. Iran J.Pharm , 2012; 11: 611-620
19. Ma, Y., Chen, S., Chen, M., Ren, X., Patel, N., Liu, W., Huang, H., Zhou, R., Zhang, K., Goodin, S., Li, D., & Zheng, X. Combination of diethyldithiocarbamate with 12-O-tetradecanoyl phorbol-13-acetate inhibits the growth of human myeloid leukemia HL-60 cells in vitro and in xenograft model. Bioscience, Biotechnology and Biochemistry, 2020; 2069–2076.
20. Mahmoud, Youssef A, EL-Feky A, El Sayed N, M Seif, Kamal H. Evaluation of Antioxidant Efficiency of Croton tiglium L Seeds Extracts After Incorporating Silver Nanoparticles. Egypt.J, 2019;62; 181-200
21. Matsuya, Y., Yu, Z., Yamamoto, N., Mori, M., Saito, H., Takeuchi, M., Ito, M., & Nemoto, H. (2005). Synthesis of new phorbol derivatives having ethereal side chain and evaluation of their anti-HIV activity. Bioorganic and Medicinal Chemistry, 2005; 13(14) : 4383–4388.
22. Mudium R, Kolasani B. Anticonvulsant Effect of Hydroalcoholic Seed Extract of Croton tiglium in Rats and Mice. J.Clin Diagns, 2014; 8(24): 1-6
23. Omran, A. M., & Ali, S. A. Histopathologic Changes in Liver Tissues From Male Albino Rats Treated with Croton tiglium Mixed With Animals Diet. In JFST Issue , 2019; 6 (2019): 152-156
24. Raveneli N, Santos KP, Matta LB, Lago JHG, Furlan. Alkaloid from Croton echinocarpus : Anti HIV Potential. E South African Journal of Botani, 2015
25. Sancbual M, Okurhama NN, Clark M. Croton palanostigma Induces Apoptosis in Human Gastrointestinal Cancer Cells. J Ethopharmacol, 2012; 80 (121): 1-9
26. Saputera, Djaya A. Uji Aktivitas Biji Kamandrah (Croton tiglium L.) sebagai Bioinsektisida Nabati Hama Wereng Coklat.J. Agripeat, 2014 ; 2(15): 82-87
27. Sahar EM, Meselhy R. Meselhya, Norio N, Masao H, Takuya K, Toru O. Anti HIV-1 phorbol esters from the seeds of Croton tiglium. Phytochemistry, 1994; 53: 457- 464
28. Shahid, M., Tayyab, M., Naz, F., Jamil, A., Ashraf, M., & Gilani, A. H. Activity-guided Isolation of a Novel Protein from Croton tiglium with Antifungal and Antibacterial Activities. Phytother. Res, 2008; 22: 1646–1649.
29. Vogg, G., Achatz, S., Kettrup, A., & Sandermann, H. Fast, sensitive and selective liquid chromatographic-tandem mass spectrometric determination of tumor-promoting diterpene esters. In Journal of Chromatography A , 1999; 855 (1999)
30. Wang, J. F., Yang, S. H., Liu, Y. Q., Li, D. X., He, W. J., Zhang, X. X., Liu, Y. H., & Zhou, X. J. Five new phorbol esters with cytotoxic and selective anti-inflammatory activities from Croton tiglium. Bioorganic and Medicinal Chemistry Letters, 2015; 25(9): 1986–1989.
31. Yan, P., Zhang, L., Peng, C., & Zhang, R. Pharmacokinetics and tissue distribution of crotonoside. Xenobiotica, 2018; 48(1): 28–36.
32. Yumnamcha, T., Devi, M. D., Roy, D., & Nongthomba, U. Evaluation of developmental toxicity and genotoxicity of aqueous seed extract of Croton tiglium L. using zebrafish. Drug and Chemical Toxicology, 2022; 45(1): 398–406.
33. Zhang, X. L., Khan, A. A., Wang, L., Yu, K., Li, F., & Wang, M. K. Four new phorbol diesters from Croton tiglium and their cytotoxic activities. Phytochemistry Letters, 2016; 16: 82–86.
34. Zhang, D. D., Zhou, B., Yu, J. H., Xu, C. H., Ding, J., Zhang, H., & Yue, J. M. Cytotoxic tigliane-type diterpenoids from Croton tiglium. Tetrahedron, 2015; 71(52): 9638–9644.
35. Zhao, B. Q., Peng, S., He, W. J., Liu, Y. H., Wang, J. F., & Zhou, X. J. Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium. Bioorganic and Medicinal Chemistry Letters, 2016; 26(20): 4996–4999.



How to Cite

Kurniasari, F., & Widyasti, J. H. (2023). Review of the Potential of Kamandrah (Croton Tiglium L.) As A Medicinal Plant. Asian Journal of Pharmaceutical Research and Development, 11(6), 1–6.