Review of Active Compounds from Medicinal Plants with Antihyperglycemic Efficiency on Translocation and Expression of Glucose Transporter 4 on Muscle and Adipose Tissue

  • Jena Hayu Widyasti Faculty of Pharmacy, Universitas Setia Budi,Surakarta, Indonesia, 57127
  • Fitri Kurniasari Faculty of Pharmacy, Universitas Setia Budi,Surakarta, Indonesia, 57127
  • Rahmat Budi Nugroho Faculty of Pharmacy, Universitas Setia Budi,Surakarta, Indonesia, 57127


Glucose transporter’s mechanism is influenced by the presence of insulin, especially GLUT4 which acts on muscle, adipose, and brain tissue. Medicinal plants with active compounds that were able to regulate the expression and translocation of GLUT helps in the treatment of insulin resistance and hyperglycemia. This study aimed to determine which active compounds isolated from medicinal plants have antihyperglycemic activity on GLUT4 expression in muscle and adipose tissue. The research method used was by searching the literature electronically with the keywords "Plant Isolation", "Chemical Compounds", "Antihyperglycemic Activity", and "Glucose transporter (GLUT) 4". Literature sources in the form of international and national journals have been found on several sites, such as NCBI, Elsevier and Pubmed, and others. A literature search in the form of selected journals from 2016 to 2021. The data were analyzed using the PRISMA (Prefered Reporting Items for Systematic Review and Meta-analyses) method. The results showed that the active substances contained in the plant have antihyperglycemic activity by increasing the translocation and expression of GLUT4 in skeletal muscle cells, adipocytes, and tested-animal models of DM.


Keywords: Antihyperglycemic, GLUT4, active compounds, Glucose Transporters


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Author Biographies

Jena Hayu Widyasti, Faculty of Pharmacy, Universitas Setia Budi,Surakarta, Indonesia, 57127

Faculty of Pharmacy, Universitas Setia Budi,Surakarta, Indonesia, 57127

Fitri Kurniasari, Faculty of Pharmacy, Universitas Setia Budi,Surakarta, Indonesia, 57127

Faculty of Pharmacy, Universitas Setia Budi,Surakarta, Indonesia, 57127

Rahmat Budi Nugroho, Faculty of Pharmacy, Universitas Setia Budi,Surakarta, Indonesia, 57127

Faculty of Pharmacy, Universitas Setia Budi,Surakarta, Indonesia, 57127


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How to Cite
Widyasti, J., Kurniasari, F., & Nugroho, R. (2022). Review of Active Compounds from Medicinal Plants with Antihyperglycemic Efficiency on Translocation and Expression of Glucose Transporter 4 on Muscle and Adipose Tissue. Asian Journal of Pharmaceutical Research and Development, 10(4), 70-75.