DESIGN AND DEVELOPMENT OF CHRONOPHARMACEUTICAL DRUG DELIVERY OF LANSOPRAZOLE

Authors

  • M. Sandeep Bapatla College of Pharmacy, Bapatla, Andhra Pradesh, India.
  • V. Sai Kishore Bapatla College of Pharmacy, Bapatla, Andhra Pradesh, India.
  • B. Sudheer Bapatla College of Pharmacy, Bapatla, Andhra Pradesh, India.
  • S. Ershad Bapatla College of Pharmacy, Bapatla, Andhra Pradesh, India.
  • K. Adithya Bapatla College of Pharmacy, Bapatla, Andhra Pradesh, India.
  • D. S Phanil kumar Siddhartha institute of pharmacy, Jonnalagadda, Narsaraopeta, Andhra Pradesh, India.

Keywords:

Lansoprazole, wet granulation method, Hydrogel plug, Pulsing cap, Stability studies

Abstract

The aim of the present investigation is to develop a pulsatile drug delivery system basedon an insoluble capsule body filled
with Lansoprazole matrix tablet and sealed with HPMC K 100 plug. The Lansoprazole matrix tablets were prepared by wet
granulation method. The plugs of varying thickness and hardness were prepared by direct compression which was then
placed in the capsule opening. The drug delivery system was designed to deliver the drug at such a time when it was needed
(nocturnal time). Dissolution studies of pulsatile capsule device in media with different pH (1.2, 7.4 and6.8) showed that
drug release in colon could be modulated by optimizing the concentration of polymers in the plug and also the position of
plug. The study showed that, lag time prior to drugrelease was highly affected by the plug position. The dissolution data
revealed that the plug position and the composition of plug were very important to achieve a optimum formulation.Drug–
polymer interaction studies indicated no interaction or complexation in between the drug and the polymer.

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Published

2013-09-01

How to Cite

Sandeep, M., Kishore, V. S., Sudheer, B., Ershad, S., Adithya, K., & Phanil kumar, D. S. (2013). DESIGN AND DEVELOPMENT OF CHRONOPHARMACEUTICAL DRUG DELIVERY OF LANSOPRAZOLE. Asian Journal of Pharmaceutical Research and Development, 1(5), 63–70. Retrieved from https://ajprd.com/index.php/journal/article/view/115

Issue

Volume 1st Issue 5th Sep-Oct 2013

Section

Research Articles

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